A linear, completely nonhomogeneous, generally nonlocal, multipoint problem is investigated for a second-order ordinary integro-differential equation with generally nonsmooth coefficients, satisfying some general conditions like p-integrability and boundedness. A system of three integro-algebraic equations named the adjoint system is introduced for the solution. The solvability conditions are found by the solutions of the homogeneous adjoint system in an “alternative theorem”. A version of a Green’s functional is introduced as a special solution of the adjoint system. For the problem with a nontrivial kernel also a notion of a generalized Green’s functional is introduced by a projection operator defined on the space of solutions. It is also shown that the classical Green and Cauchy type functions are special forms of the Green’s functional.