Classical Complex Research Articles

Unveiling the dynamic evolution of innovation networks in emerging economies: A complex network approach

AbstractThe innovation network of enterprises in emerging economies is a complex system, comprising numerous interconnected elements. In the context of a dynamic and volatile market, innovation entities evolve the evolution of the local world through collaborative innovation and interactions. To accurately replicate the actual dynamics of the enterprise innovation network, an in‐depth analysis is essential to delineate the growth and reduction mechanisms of diverse nodal entities. This research, based on the classical complex network paradigm, proposes a model that is based on preferential attachment and pruning mechanisms. This model reflects the evolutionary trajectory of enterprise innovation networks and was subjected to simulation analysis using MATLAB. The findings prove that simulation is an effective analytical tool for understanding the evolutionary mechanisms of innovation networks within emerging economies. The model clearly demonstrates the complex evolution of enterprise innovation networks, providing both theoretical foundations and practical guidance for strategic resource allocation and network governance within corporate environments.

Unveiling the impact of Leptospira TolC efflux protein on host tissue adherence, complement evasion, and diagnostic potential.

The TolC family protein of Leptospira is a type I outer membrane efflux protein. Phylogenetic analysis revealed significant sequence conservation among pathogenic Leptospira species (83%-98% identity) compared with intermediate and saprophytic species. Structural modeling indicated a composition of six β-strands and 10 α-helices arranged in two repeats, resembling bacterial outer membrane efflux proteins. Recombinant TolC (rTolC), expressed in a heterologous host and purified via Ni-NTA chromatography, maintained its secondary structural integrity, as verified by circular dichroism spectroscopy. Polyclonal antibodies against rTolC detected native TolC expression in pathogenic Leptospira but not in nonpathogenic ones. Immunoassays and detergent fractionation assays indicated surface localization of TolC. The rTolC's recognition by sera from leptospirosis-infected hosts across species suggests its utility as a diagnostic marker. Notably, rTolC demonstrated binding affinity for various extracellular matrix components, including collagen and chondroitin sulfate A, as well as plasma proteins such as factor H, C3b, and plasminogen, indicating potential roles in tissue adhesion and immune evasion. Functional assays demonstrated that rTolC-bound FH retained cofactor activity for C3b cleavage, highlighting TolC's role in complement regulation. The rTolC protein inhibited both the alternative and the classical pathway-mediated membrane attack complex (MAC) deposition in vitro. Blocking surface-expressed TolC on leptospires using specific antibodies reduced FH acquisition by Leptospira and increased MAC deposition on the spirochete. These findings indicate that TolC contributes to leptospiral virulence by promoting host tissue colonization and evading the immune response, presenting it as a potential target for diagnostic and therapeutic strategies.

Detachment and Transfer Fault Systems in the Northern South China Sea, Insights Into 3D Tectonic Segmentation of Rifted Margins

AbstractThe 2D rifting modes interpreted in traditional “magma‐poor” and “magma‐rich” margins cannot explain the crustal structure and inferred rifting processes in the northern South China Sea (SCS) rifted margin. The “intermediate‐type” terminology has been therefore applied to the mid‐northern SCS, where a “wide‐rift” model has been widely accepted. However, the tectono‐magmatic processes of the SCS are still debated and at least five contrasting models exist. We present a compilation of 3‐D seismic volumes and regional 2‐D seismic surveys covering the entire Baiyun and Liwan Sub‐basins to investigate their tectonic structure and faulting style in this “wide‐rift” region. We interpret two segments with contrasting tectonic styles separated by a volcanic lineament and steep transfer faults. The Baiyun Sub‐basin was controlled by a landward‐dipping detachment system. The Liwan Sub‐basin, however, was formed by a ∼100 km‐long oceanward‐dipping, concave‐up detachment fault working at a low angle of <10°. The lateral boundaries of the detachment system were mechanically decoupled from surrounding tectonics by a volcanic lineament/transfer zone to the west and a > 190 km‐long N‐S‐trending left‐lateral strike‐slip fault to the east. The planar low‐angle detachment does not resemble classical metamorphic core complex domes interpreted previously. Our results indicate a 60‐80 km‐wavelength segmentation within a single “wide‐rift” system, indicating complex 3D rifting during crustal extension. This study supports that the intermediate SCS margin had a kinematically complex deformation style locally dominated by the interaction between detachment and transfer fault systems that might be yet unrecognized in other margins.

A Lead-μ2-Tetrylide Complex with Osmium(IV) Terminal Components.

A bare lead atom is a σ-donor ligand capable of linearly bonding and stabilizing two units of a classical polyhydride complex, with a high-valent metal center. As a proof of concept, we have prepared and characterized the μ2-tetrylide complex (PiPr3)2H4Os═Pb═OsH4(PiPr3)2 in the reaction of OsH6(PiPr3)2 with Pb{N(SiMe3)2}2. Although the Pb-Os bonds exhibit electrostatic interaction, the main orbital interactions result from two dative σ bonds from the lead atom to the osmium centers. The latter also provide much weaker π-backdonations.

A hyperparameter study for quantum kernel methods

Quantum kernel methods are a promising method in quantum machine learning thanks to the guarantees connected to them. Their accessibility for analytic considerations also opens up the possibility of prescreening datasets based on their potential for a quantum advantage. To do so, earlier works developed the geometric difference, which can be understood as a closeness measure between two kernel-based machine learning approaches, most importantly between a quantum kernel and a classical kernel. This metric links the quantum and classical model complexities, and it was developed to bound generalization error. Therefore, it raises the question of how this metric behaves in an empirical setting. In this work, we investigate the effects of hyperparameter choice on the model performance and the generalization gap between classical and quantum kernels. The importance of hyperparameters is well known also for classical machine learning. Of special interest are hyperparameters associated with the quantum Hamiltonian evolution feature map, as well as the number of qubits to trace out before computing a projected quantum kernel. We conduct a thorough investigation of the hyperparameters across 11 datasets, and we identify certain aspects that can be exploited. Analyzing the effects of certain hyperparameter settings on the empirical performance, as measured by cross validation accuracy, and generalization ability, as measured by geometric difference described above, brings us one step closer to understanding the potential of quantum kernel methods on classical datasets.

Fixed Points of Involutions of G-Higgs Bundle Moduli Spaces over a Compact Riemann Surface with Classical Complex Structure Group

Fixed Points of Involutions of G-Higgs Bundle Moduli Spaces over a Compact Riemann Surface with Classical Complex Structure Group

The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance

RNA constitutes a large fraction of chromatin. Spatial distribution and functional relevance of most of RNA-chromatin interactions remain unknown. We established a landscape analysis of RNA-chromatin interactions in human acute myeloid leukemia (AML). In total more than 50 million interactions were captured in an AML cell line. Protein-coding mRNAs and long non-coding RNAs exhibited a substantial number of interactions with chromatin in cis suggesting transcriptional activity. In contrast, small nucleolar RNAs (snoRNAs) and small nuclear RNAs (snRNAs) associated with chromatin predominantly in trans suggesting chromatin specific functions. Of note, snoRNA-chromatin interaction was associated with chromatin modifications and occurred independently of the classical snoRNA-RNP complex. Two C/D box snoRNAs, namely SNORD118 and SNORD3A, displayed high frequency of trans-association with chromatin. The transcription of SNORD118 and SNORD3A was increased upon leukemia transformation and enriched in leukemia stem cells, but decreased during myeloid differentiation. Suppression of SNORD118 and SNORD3A impaired leukemia cell proliferation and colony forming capacity in AML cell lines and primary patient samples. Notably, this effect was leukemia specific with less impact on healthy CD34+ hematopoietic stem and progenitor cells. These findings highlight the functional importance of chromatin-associated RNAs overall and in particular of SNORD118 and SNORD3A in maintaining leukemia propagation.

C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells

Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The incidence of cSCC is increasing globally and the prognosis of metastatic disease is poor. Currently there are no specific targeted therapies for advanced or metastatic cSCC. We have previously shown abundant expression of the complement classical pathway C1 complex components, serine proteases C1r and C1s in tumor cells in invasive cSCCs in vivo, whereas the expression of C1r and C1s was lower in cSCCs in situ, actinic keratoses and in normal skin. We have also shown that knockdown of C1s expression results in decreased viability and growth of cSCC cells by promoting apoptosis both in culture and in vivo. Here, we have studied the effect of specific IgG2a mouse monoclonal antibodies TNT003 and TNT005 targeting human C1s in five primary non-metastatic and three metastatic cSCC cell lines that show intracellular expression of C1s and secretion of C1s into the cell culture media. Treatment of cSCC cells with TNT003 and TNT005 significantly inhibited their growth and viability and promoted apoptosis of cSCC cells. These data indicate that TNT003 and TNT005 inhibit cSCC cell growth in culture and warrant further investigation of C1s targeted inhibition in additional in vitro and in vivo models of cSCC.

Holomorphy over Finite-dimensional Commutative Associative C-algebras: Local Theory

To a morphism $$\mathcal{A} \xrightarrow{\varphi} \mathcal{B}$$ of finite-dimensional commutative associative unital Banach $$\mathbb{C}$$-algebras one can associate a sheaf $$\mathcal{O}_\varphi$$ on the underlying topological space $$|\mathcal{A}|$$ of $$\mathcal{A}$$ consisting of $$\mathcal{B}$$-valued differentiable functions $$f$$ with $$\mathcal{A}$$-linear differential $$Df$$. It turns out that this class of functions exhibits a theory very similar to the classical complex analysis of one variable. In this article we give only an overview of some new results concerning the fundamentals of the corresponding local theory while at the same time also strengthen various already existing results scattered throughout the literature.

Hysteretic models with damage and flexibility increase

The need to accurately describe nonlinear degrading phenomena in both modern and classical complex materials that exhibit hysteretic behavior is a relevant task for the analysis of their response. In the present study an enrichment to an existing formulation to describe strength and stiffness degradation is proposed. The description of damage, that reduces the hysteretic force, is then accompanied by the introduction of flexibility increase, which increments the elastic displacement experienced by the system. Both effects influence the energy dissipated by the system. The condition of thermodynamic admissibility in presence of damage and flexibility increase is derived, entailing constraints on system parameters. Additional constraints arise from consistency conditions on the transformation of the pure hysteretic system into the system with damage and flexibility increase. A numerical solution involving the forward Euler method is presented to evaluate the response quantities. The formulation is eventually applied to the elastic–plastic and Bouc Wen hysteresis models, and the influence of the degrading parameters is presented. The presented Bouc-Wen model with damage and flexibility increase is applied to study the cyclic response of a masonry panel experimentally tested to validate the numerical model and prove its capability of describing the structural response.

Harnessing Bioluminescent Bacteria to Develop an Enzymatic-free Enzyme-linked immunosorbent assay for the Detection of Clinically Relevant Biomarkers.

Enzyme-linked immunosorbent assay (ELISA) is the gold standard technique for measuring protein biomarkers due to its high sensitivity, specificity, and throughput. Despite its success, continuous advancements in ELISA and immunoassay formats are crucial to meet evolving global challenges and to address new analytical needs in diverse applications. To expand the capabilities and applications of immunoassays, we introduce a novel ELISA-like assay that we call Bioluminescent-bacteria-linked immunosorbent assay (BBLISA). BBLISA is an enzyme-free assay that utilizes the inner filter effect between the bioluminescent bacteriaAllivibrio fischeriand metallic nanoparticles (gold nanoparticles and gold iridium oxide nanoflowers) as molecular absorbers. Functionalizing these nanoparticles with antibodies induces their accumulation in wells upon binding to molecular targets, forming the classical immune-sandwich complex. Thanks to their ability to adsorb the light emitted by the bacteria, the nanoparticles can suppress the bioluminescence signal, allowing the rapid quantification of the target. To demonstrate the bioanalytical properties of the novel immunoassay platform, as a proof of principle, we detected two clinically relevant biomarkers (human immunoglobulin G and SARS-CoV-2 nucleoprotein) in human serum, achieving the same sensitivity and precision as the classic ELISA. We believe that BBLISA can be a promising alternative to the standard ELISA techniques, offering potential advancements in biomarker detection and analysis by combining nanomaterials with a low-cost, portable bioluminescent platform.

Unlocking Four-electron Conversion in Tellurium Cathodes for Advanced Magnesium-based Dual-ion Batteries.

Magnesium (Mg) batteries hold promise as a large-scale energy storage solution, but their progress has been hindered by the lack of high-performance cathodes. Here, we address this challenge by unlocking the reversible four-electron Te0/Te4+ conversion in elemental Te, enabling the demonstration of superior Mg//Te dual-ion batteries. Specifically, the classic magnesium aluminum chloride complex (MACC) electrolyte is tailored by introducing Mg bis(trifluoromethanesulfonyl)imide (Mg(TFSI)2), which initiates the Te0/Te4+ conversion with two distinct charge-storage steps. Te cathode undergoes Te/TeCl4 conversion involving Cl- as charge carriers, during which a tellurium subchloride phase is presented as an intermediate. Significantly, the Te cathode achieves a high specific capacity of 543 mAh gTe -1 and an outstanding energy density of 850 Wh kgTe -1, outperforming most of the previously reported cathodes. Our electrolyte analysis indicates that the addition of Mg(TFSI)2 reduces the overall ion-molecule interaction and mitigates the strength of ion-solvent aggregation within the MACC electrolyte, which implies the facilized Cl- dissociation from the electrolyte. Besides, Mg(TFSI)2 is verified as an essential buffer to mitigate the corrosion and passivation of Mg anodes caused by the consumption of the electrolyte MgCl2 in Mg//Te dual-ion cells. These findings provide crucial insights into the development of advanced Mg-based dual-ion batteries.

Unlocking Four‐electron Conversion in Tellurium Cathodes for Advanced Magnesium‐based Dual‐ion Batteries

AbstractMagnesium (Mg) batteries hold promise as a large‐scale energy storage solution, but their progress has been hindered by the lack of high‐performance cathodes. Here, we address this challenge by unlocking the reversible four‐electron Te0/Te4+ conversion in elemental Te, enabling the demonstration of superior Mg//Te dual‐ion batteries. Specifically, the classic magnesium aluminum chloride complex (MACC) electrolyte is tailored by introducing Mg bis(trifluoromethanesulfonyl)imide (Mg(TFSI)2), which initiates the Te0/Te4+ conversion with two distinct charge‐storage steps. Te cathode undergoes Te/TeCl4 conversion involving Cl− as charge carriers, during which a tellurium subchloride phase is presented as an intermediate. Significantly, the Te cathode achieves a high specific capacity of 543 mAh gTe−1 and an outstanding energy density of 850 Wh kgTe−1, outperforming most of the previously reported cathodes. Our electrolyte analysis indicates that the addition of Mg(TFSI)2 reduces the overall ion‐molecule interaction and mitigates the strength of ion‐solvent aggregation within the MACC electrolyte, which implies the facilized Cl− dissociation from the electrolyte. Besides, Mg(TFSI)2 is verified as an essential buffer to mitigate the corrosion and passivation of Mg anodes caused by the consumption of the electrolyte MgCl2 in Mg//Te dual‐ion cells. These findings provide crucial insights into the development of advanced Mg‐based dual‐ion batteries.

Self-Repairing [MEDTA]2- functionalized poly(ionic liquid)s in the application of NH3 adsorption through reversible NH3 insertion

MOFs have high adsorption performance of ammonia (NH3) because of its porosity and abundant coordination sites, especially MOFs containing carboxylic acid ligands have emerged as effect NH3 adsorbents. But, it’s troublous for reversible ammonia adsorption for the strong metal-NH3 coordination or the collapse of adsorbents. [MEDTA]2- is a very stable and classic carboxylic acid-containing complex, but there was no relevant report. Therefore, this work carried out the design and synthesis of PVIm-R8-MEDTA based on the use of the coordination structure of [MEDTA]2- and the stability of PILs’ skeleton. The characterization indicated the [MEDTA]2- could be introduced into PILs successfully for the hydrogen bonding interactions with the imidazolium cation, and the obtained PVIm-R8-MEDTA presented enhanced NH3 capacity (10.4–14.7 mmol/g) than their precursor PVIm-R8-Br (7.8 mmol/g). The mechanism of NH3 adsorption was proposed by DFT calculation, spectroscopic method, and the calorimetric test, it indicated the NH3 was fixed by imdazolium cation through hydrogen bonding and inserted into two of the carboxylate and metal bonds of [MEDTA]2-. Because of the multi-meshing coordination of [EDTA]4- and metal ions, the disconnected carboxylate ions could easily coordinate with metal ions again and repair the chelating structure of [MEDTA]2-, which caused the ammonia easily be desorbed. In the process of gas adsorption, there was no bonding breakage of the skeleton of PILs, which helped the PVIm-R8-MEDTA be recovered under moisture and NH3 atmosphere. Thanks for the designability of PILs, such as the cationic structure, structure and size of cross-linking agent, the choice of complex anion and so on, it provides a new design idea and theoretical basis for efficient and reversible ammonia adsorption materials.

On the convergence of series of fractional Hasse derivative bases in Fréchet spaces

This paper introduces a generalization of the Hasse derivative in the sense of the complex conformable derivative. The definition coincides with the classical version of the Hasse derivative of order . Accordingly, a new base, named complex conformable Hasse derivative bases (CCHDBs), is defined. We investigate the existence of expansions of analytic functions in a series of CCHDBs in Fréchet space on closed and open disks, open regions surrounding closed disks, for all entire functions and at the origin. Moreover, an upper bound for the order and type of the CCHDBs is obtained and proved to be attainable. The ‐property of CCHDBs is also discussed. Our results improve and extend the analog results in the complex analysis related to the classical complex derivative of a base of polynomials (BPs). The obtained results clarify several implications for the CCHDBs of special functions such as Euler, Bernoulli, Chebyshev, Bessel, and Gontcharaff polynomials.

Uncharted territories: Solving the mysteries of male meiosis in flies.

The segregation of homologous chromosomes during meiosis typically requires tight end-to-end chromosome pairing. However, in Drosophila spermatogenesis, male flies segregate their chromosomes without classic synaptonemal complex formation and without recombination, instead compartmentalizing homologs into subnuclear domains known as chromosome territories (CTs). How homologs find each other in the nucleus and are separated into CTs has been one of the biggest riddles in chromosome biology. Here, we discuss our current understanding of pairing and CT formation in flies and review recent data on how homologs are linked and partitioned during meiosis in male flies.

Visual Corticotectal Neurons in Awake Rabbits: Receptive Fields and Driving Monosynaptic Thalamocortical Inputs.

The superior colliculus receives powerful synaptic inputs from corticotectal neurons in the visual cortex. The function of these corticotectal neurons remains largely unknown due to a limited understanding of their response properties and connectivity. Here, we use antidromic methods to identify corticotectal neurons in awake male and female rabbits, and measure their axonal conduction times, thalamic inputs and receptive field properties. All corticotectal neurons responded to sinusoidal drifting gratings with a nonlinear (nonsinusoidal) increase in mean firing rate but showed pronounced differences in their ON-OFF receptive field structures that we classified into three groups, Cx, S2, and S1. Cx receptive fields had highly overlapping ON and OFF subfields as classical complex cells, S2 had largely separated ON and OFF subfields as classical simple cells, and S1 had a single ON or OFF subfield. Thus, all corticotectal neurons are homogeneous in their nonlinear spatial summation but very heterogeneous in their spatial integration of ON and OFF inputs. The Cx type had the fastest conducting axons, the highest spontaneous activity, and the strongest and fastest visual responses. The S2 type had the highest orientation selectivity, and the S1 type had the slowest conducting axons. Moreover, our cross-correlation analyses found that a subpopulation of corticotectal neurons with very fast conducting axons and high spontaneous firing rates (largely "Cx" type) receives monosynaptic input from retinotopically aligned thalamic neurons. This previously unrecognized fast-conducting thalamic-mediated corticotectal pathway may provide specialized information to superior colliculus and prime recipient neurons for subsequent corticotectal or retinal synaptic input.

ОСОБЕННОСТИ ДИАГНОСТИКИ И ВЕДЕНИЯ ПАЦИЕНТКИ С СИНДРОМОМ ФРЕДЕРИКА (КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ)

Description of a clinical case. The article presents a clinical observation of a 77-year-old patient with newly diag-nosed Frederick’s syndrome, which is a combination of a permanent form of atrial fibrillation and complete atrioven-tricular block. An exacerbation of chronic pancreatitis was the reason for hospitalization of the patient. The patient had no complaints of bradycardia or syncope, but treatment of the underlying disease was difficult due to the development of acute kidney injury against the background of chronic kidney disease and uncompensated chronic heart failure. The cause of the development of Frederick’s syndrome was pronounced myocardium remodeling due to diseases that make up the classic complex of metabolic syndrome – coronary heart disease, arterial hypertension, type 2 dia-betes mellitus and obesity. Conclusion. The analysis of a few domestic and foreign literature sources showed that the development of Frederick’s syndrome is associated with a worsening prognosis and the development of various complications, which is usually underestimated by attending physicians. Taking into account the difficulties of diagnosis and management of patients with this pathology, it is necessary to be wary of the development of Frederick’s syndrome, especially in comorbid elderly and senile patients. Timely medical correction and referral of the patient for surgical treatment will improve the prognosis and reduce mortality in patients with atrial fibrillation.

Age, origin and tectonic controls on rapid recent exhumation of the Sibela Mountains, Bacan, Indonesia

The Sibela Mountains of the island of Bacan in eastern Indonesia contain one of the Earth’s youngest metamorphic complexes that is now exposed at elevations up to 2000 m. New mica 40Ar/39Ar and apatite (U–Th–Sm)/He data from metamorphic and igneous rocks indicate that these rocks were rapidly exhumed in the Pleistocene (c. 0.7 Ma). Exhumation of the metamorphosed Permo-Triassic basement (c. 249–257 Ma) was accompanied by metamorphism (recorded by schists) as well as partial melting (recorded by c. 1.4 Ma granitic dykes). These processes must have occurred at extremely high cooling and exhumation rates. The rapid exhumation on land was associated with significant subsidence in adjacent basins offshore that reach depths up to 2.4 km. Neogene metamorphic core complexes and other metamorphic complexes are well-known from eastern Indonesia, but they usually record much higher exhumation rates than those reported from older classic metamorphic core complexes found in other parts of the world and require a different formation mechanism. Unlike classic metamorphic core complexes that are characterized by low-angle detachment faults, the Bacan metamorphic rocks were exhumed on steep bounding normal faults forming a rectilinear block pattern. We suggest such complexes are termed metamorphic block complexes (MBC). The Bacan MBC is exceptionally young and like the other east Indonesian complexes was rapidly exhumed during subduction rollback. A flexure formed during arc-arc collision as the Sangihe forearc loaded the Halmahera forearc which reactivated steeply-dipping faults in a rectilinear chocolate block pattern.Graphical abstractThe Sibela Mountains of the island of Bacan in eastern Indonesia are formed by one of the Earth’s youngest metamorphic complexes. a Dense rain forest cover and steep flanks of the Sibela Mountains which rise from sea level to more than 2000 m. b Quaternary collision between the Sangihe and Halmahera arcs. Loading of the Halmahera forearc formed a flexure that reactivated steeply-dipping faults, which exhumed the Sibela Mountains metamorphic block. c Rapid cooling paths during exhumation of the Sibela metamorphic complex

Effect of the Formation of Hydrophilic and Hydrophobic-Hydrophilic Associates on the Behavior of Copolymers of N-Vinylpyrrolidone with Methyl Acrylate in Aqueous Solutions.

It has been shown that there exist conditions under which thermosensitive copolymers of N-vinylpyrrolidone with methyl acrylate form hydrophobic-hydrophilic associations, which are unstable dynamic meshes, the bonds in which are continuously broken and created again, and the nature of the formation of such meshes depends significantly on the proportion of the hydrophobic component in the copolymer. It is shown that the interaction of the above copolymers with polyacrylic acid results in the formation of not only classical interpolymer complexes, but also hydrophilic interpolymer associates, which also represent unstable networks existing in a dynamic mode. In such meshes, the molecules of the above copolymers serve as a kind of cross-agent connecting the polyacid molecules. There are also conditions under which such meshes acquire a complex structure, since unstable bonds between macromolecular tangles of both the same and different types take part in their formation. It is shown that the transition from the formation of interpolymer complexes to the formation of hydrophilic interpolymer associates can occur, among other things, due to changes in the acidity or concentration of low-molecular salt in solution.