In this paper, an adaptive estimation technique is proposed for the estimation of time-varying parameters for a class of continuous-time nonlinear system. A set-based adaptive estimation is used to estimate the time-varying parameters along with an uncertainty set. The proposed method is such that the uncertainty set update is guaranteed to contain the true value of the parameters. Unlike existing techniques that rely on the use of polynomial approximations of the time-varying behaviour of the parameters, the proposed technique does require a functional representation of the time-varying behaviour of the parameter estimates. A simulation example and a building systems estimation example are considered to illustrate the developed procedure and ascertain the theoretical results.