Class IIb Research Articles

Pelayanan Jam Kunjungan Warga Binaan Di LembagaPemasyarakatan Terbuka Kelas IIB Nusakambangan

This research aims to determine the visiting hours service for inmates atthe Class IIB Nusakambangan Open Penitentiary and to find out theobstacles faced in the visiting hours service for Inmates at the Class IIBNusakambangan Open Penitentiary. The approach method used in thisresearch is a normative juridical research method and the analysis in thisresearch uses a qualitative analysis method. The results of the research atthe Class IIB Nusakambangan Open Penitentiary, namely that visitinghours services for inmates at the Class IIB Nusakambangan OpenPenitentiary were carried out in accordance with the rules stipulated inthe Operational Standards, Service Standards and GovernmentRegulation No. 99 of 2012 concerning Requirements and Procedures forthe Implementation of the Rights of Inmates in Prisons with theimplementation of visiting schedules, guarantees provided and servicesfrom other visiting hours and obstacles faced in serving visiting hours forinmates at the Class IIB Nusakambangan Open Penitentiary, namelylimited crossings for to the Nusakambangan Open Prison location in thespecial Nusakambangan Island Correctional Area and strict procedures,namely administration regarding the Village Head's certificate. However,despite the obstacles, the Class IIB Nusakambangan Open Penitentiary isworking as a solution, namely providing relief for the Village Head'scertificate to be followed up on the next visit provided that the visitor stillhas one Family Card and continues to provide the best service byproviding video call services so that the WBP can still communicate withtheir families.

Motivasi Lepas Adiksi Narapidana Narkoba

The existence of family support for prisoners is very important because it produces many benefits, one of which is motivation to improve themselves. Drug prisoners are one of the prisoners who really need family support, because there is a phenomenon of addiction that is felt. This study will attempt to show the influence provided by family support on the level of motivation of prisoners, especially to escape drug addiction. The research method used is a quantitative method with a type of correlation research followed by regression analysis. The research respondents used were drug prisoners in Tulungagung Class IIB Correctional Facility with a total of 33 people. Data collection was carried out using questionnaire techniques, namely family support questionnaire and addiction release motivation questionnaire. Referring to the results of the study, it is known that the family support variable has a significant positive effect on the emergence of the variable of motivation to escape addiction in drug prisoners in Tulungagung Class IIB Correctional Facility. This result is based on the calculated t value obtained, which is 7.361. This figure is greater than the t table, which is 1,692 so that the research results accept the Ha hypothesis which means it has a significant effect. The regression equation obtained is Y = 6,691 + 0,669X which has several interpretations of meaning, namely: (1) If the family support variable = 0 (constant), then the value of the addiction release motivation variable is 6.691; and (2) Every additional value in the family support variable, there is an additional value in the addiction release motivation variable of 0,669.

Abstract LB210: Identification of histone deacetylase 10 as a repressor of cancer cell migration

Abstract Histone deacetylases (HDACs) are a family of 18 enzymes with the potential to be epigenetic modifiers. Of the 4 classes of HDACs, HDAC6 and HDAC10 belong to the class IIb subgroup. Unlike HDAC6, HDAC10 contains two deacetylase-like domains, with one active deacetylase domain and one inactive leucine-rich domain, and a preference for a specific acetylated polyamine over other substrates. Aberrant expression of HDAC10 has been implicated in cancer and other diseases. However, the deacetylation targets and biological functions of HDAC10 have not been well characterized due to a lack of specific and potent HDAC10 inhibitors with cellular activity. We previously established CRISPR/Cas9-mediated HDAC10 knockout (KO) cell lines in HCT116 and HeLa S3 cells. In the current study, we used the HCT116 wildtype and KO pair for bulk RNA sequencing, differential gene expression, and gene set enrichment analyses (GSEA), which revealed an upregulation of gene markers and pathways potentially associated with metastasis and invasion in the HDAC10-KO cells, including S100A14, LAMA4, and TGF-beta. As the role of HDAC10 expression on cell migration and invasion has not been previously reported, we performed cell migration assays using our HDAC10 parental and knockout cell line pairs. In both HCT116 and HeLa systems, HDAC10 KO cells exhibited dramatically higher rates of cell migration in Boyden chamber and scratch assays. These same assays were performed in HDAC10-expressing cells in the presence of the HDAC10-specific inhibitor DKFZ-728, which similarly caused a dose-dependent increase in migration, strongly supporting a catalytic role for HDAC10 in repressing migration. In addition to these results, we present data investigating the role of HDAC10 in cell migration/invasion in representative prostate cancer cell lines (LNCAP and LAPC4), as the prostate tumor microenvironment is particularly rich in polyamines, including N 8-acetylated spermidine, the substrate of HDAC10. Finally, using our panel of HDAC10-KO cell lines and inhibitors, we analyze the contribution of commonly perturbed genes to the migratory phenotype with the goal of defining the precise mechanism of action. Overall, our studies provide functional evidence that loss of HDAC10 can increase cell migration, and thus, may lead to increased metastatic potential. These results emphasize the need for isoform-specific inhibitors and may have important clinical implications, as commonly utilized HDAC inhibitors, including vorinostat (SAHA), tubastatin A, and trichostatin A (TSA), also inhibit HDAC10. Our ongoing studies include incorporating HDAC10 proteolysis targeting chimeras (PROTACs) into our functional assays to examine differences between HDAC10 inhibition and PROTAC-mediated degradation, providing further rationale for modulating HDAC10 activity as an antineoplastic strategy. Citation Format: Ting-Ann Liu, Ashley Nwafor, Rajendra Kumar, Laura Sena, Raphael R. Steimbach, Aubry K. Miller, Robert A. Casero, Tracy Murray Stewart. Identification of histone deacetylase 10 as a repressor of cancer cell migration [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB210.

The Role Of The Class Iib Tanjung Pura Detention Center In Carrying Out Rehabilitation Of Women As Prisoners

The Role Of The Class Iib Tanjung Pura Detention Center In Carrying Out Rehabilitation Of Women As Prisoners

Enhanced Recovery After Surgery Cardiac Society turnkey order set for surgical-site infection prevention: Proceedings from the American Association for Thoracic Surgery ERAS Conclave 2023

ObjectivesSurgical-site infections (SSIs) after cardiac surgery increase morbidity and mortality, consume health care resources, impair recovery, and diminish patients’ quality of life. Numerous guidelines and expert consensus documents have been published to address the prevention and management of SSIs. Our objective is to integrate these documents into an order set that will facilitate the adoption and implementation of evidence-based best practices for preventing and managing SSIs after cardiac surgery. MethodsSubject matter experts were consulted to translate existing guidelines and literature into a sample turnkey order set for SSI reduction. Orders derived from consistent class I, IIA, or equivalent recommendations across referenced guidelines and consensus manuscripts appear in the turnkey order set in bold type. Selected orders that were inconsistent class I or IIA, class IIB or otherwise supported by published evidence, were also included in italicized type. ResultsPreventative care begins with the preoperative identification of both modifiable and nonmodifiable SSI risks by health care providers. Assessment tools can be used to assist in identifying patients at a high risk of SSI. Preoperative recommendations include screening for and treating Staphylococcus aureus nasal carriage. Intraoperatively, tailored prophylactic intravenous antibiotics and maintaining blood glucose levels below 180 mg/dL are essential elements. Postoperative care includes maintaining normothermia, glucose control and patient engagement. ConclusionsDespite the well-documented advantages of a multidisciplinary care pathway for SSI in cardiac surgery, there are inconsistencies in its adoption and implementation. This article provides an order set that incorporates recommendations from existing guidelines to prevent SSI in the cardiac surgical population.

Implementation of The Project Based Learning Model Lesson Study on Creativity, Abilitycreative Thinking, and Learning Outcomes

Application of the Project Based Learning (PjBL) Model Based on Lesson Study on Creativity, Creative Thinking Ability, and Learning Outcomes of Class II-B Students at SDN 1 Terara on Measuring Instrument Material. Based on the results of observations that have been made using students' learning practices in the field of Mathematics study in SDN 1 Terara for the 2023/2024 Even Semester Academic Year shows that students experience difficulties in mastering learning material on the subject of Measuring Instruments. Project Based Learning (PjBL) collaborated with Lesson Study (LS) is applied in this approach because LS is believed to be successful in improving learning practices. This implementation includes three aspects, namely: (a) Plan (Learning Planning), namely how a teacher designs learning so that students can learn actively. (b) Do (Learning Implementation) Implementation of learning that has been designed in the previous stage, where one teacher acts as a model and another teacher as an Observer of the learning. (c) See (Learning Reflection) After carrying out learning activities and observations, all parties involved reflect to discuss the learning that has been carried out and complete the parts that are still considered lacking.

Enhancing Contaminant Removal in Sewage Treatment Plant Effluent with PES/Ag Membrane

In this study, a silver-infused membrane was fabricated using an ex-situ method that involved blending silver nanoparticles (AgNPs) with Polyethersulfone (PES) as the base polymer in treating sewage treatment plant (STP) effluent. Three distinct membranes denoted as S1(Ag0), S2(Ag0.5) and S3(Ag2.0) were manufactured with varying weight percentages of polymer and silver (Ag) contents. The objective was to investigate the effect of the dosage of AgNPs on membrane characterization and performance, encompassing pure water flux filtration tests, organic rejection tests, and antibacterial properties. The results showed that all PES/Ag membranes demonstrated robust performance in removing total suspended solids (TSS), chemical oxygen demand (COD), apparent colour (Hazen unit), total dissolved solids (TDS), turbidity, conductivity, total Kjeldahl nitrogen (TKN), and Escherichia coli (E. coli), complying to Class IIB (Recreational use with body contact) of the Interim National River Water Quality Standards (INWQS) for Malaysia ruled by the Department of Environment Malaysia (DOE). The results also highlighted that upon the addition of AgNPs, the E. coli removal of the membrane S3(Ag2.0) was further improved to 99.87%. The results have evidenced that the PES/Ag membranes could reject E. coli effectively, proving their value in treating bacteria-contaminated surface water. In conclusion, this study highlights the effectiveness of PES/Ag membranes as a viable solution for domestic sewage treatment, aligning with stringent water quality requirements.

Genomic insights from Lactiplantibacillus plantarum BRD3A isolated from Atingba, a traditional fermented rice-based beverage and analysis of its potential for probiotic and antimicrobial activity against Methicillin-resistant Staphylococcus aureus.

Lactiplantibacillus plantarum BRD3A was isolated from Atingba, a traditional fermented rice-based beverage of Manipur. Its genomic sequence has 13 contigs and its genome size is 3,320,817 bp with a guanine-cytosine (GC) ratio of 44.6%. It comprises 3185 genes including 3112 coding sequences (CDSs), 73 RNAs (including 66 tRNAs and others), and one clustered regularly interspaced short palindromic repeat (CRISPR) array. A comparative and phylogenetic analysis with the Lp. plantarum genome shows that this strain has close similarity with other Lp. plantarum strains and about 99% average nucleotide identity. Functional annotation using evolutionary genealogy of genes-non-supervised orthologous groups (EggNOG) and Kyoto Encyclopedia of Genes and Genomes (KEGG) reveals genes associated with various biological processes such as metabolism, genetic information processing, and transport functions. Furthermore, the strain harbors bacteriocins like plantaricin E, Plantaricin F, and Enterocin X categorized under class IIb by the BAGEL4 database, indicating its potential antimicrobial properties. Additionally, AntiSMASH web server predicted four secondary regions-T3PKS, terpene, cyclic lactone inducer, and ribosomally synthesized and post-translationally modified peptide (RiPP)-suggesting an even higher antimicrobial potential. We validated the antimicrobial activity of Lp. plantarum BRD3A through in vitro experiments in which it exhibited promising bactericidal effects on methicillin-resistant Staphylococcus aureus, inhibiting their biofilm growth. These findings indicate the potential of Lp. plantarum BRD3A to be used as an alternative to conventional antibiotics.

Clinical characteristics of late-onset myasthenia gravis

ObjectiveLate-onset myasthenia gravis (LOMG) often has comorbidities, and its initial symptoms may be ignored or misdiagnosed as other diseases. There were few large surveys on LOMG. Our study aimed to summarize clinical characteristics of LOMG to improve the rate of correct MG diagnosis. MethodsA retrospective cohort study included 240 LOMG patients with onset age ≥65 years old who were treated at PLA General Hospital from January 1, 2003 to January 1, 2023. ResultsThe male to female ratio was 1:1.2 (P = 0.699). MGFA clinical classification: Class I 31.3%, Class IIa 12.9%, Class IIb 51.3%, Class IIIa 0.8%, Class IIIb 0.8%, Class IV 0.4%, Class V2.5%. The onset symptom was ptosis in 78.8% and diplopia was in 18.8%. Swallowing dysfunction in the stage of LOMG was in 41.7%. The incidence of thymoma in LOMG was 14.2%. 85.4% of patients antibodies against the muscle acetylcholine receptor (AChR) are detected. The overall incidence of supramaximal repetitive nerve stimulation (Jolly test) was 57.1%, among which the highest positive rate (50.7%) was in the facial nerve. Jolly test of Class IIb was tested in the highest positive rate and Class I was in the lowest one (χ2 = 7.023, P = 0.030). ConclusionThere was no significant difference in the incidence of LOMG between males and females. The clinical manifestations were mainly Class I and Class II, and severe MG was rare. The most common onset symptom was ptosis. The incidence of LOMG with thymoma was low. Supramaximal repetitive nerve stimulation (Jolly test) of the facial nerve was the easiest to detect and Jolly test of Class IIb was tested in the highest positive rate and Class I was in the lowest one.

Pengaruh e-leadership dan e-culture terhadap produktivitas kerja yang dimediasi oleh work engangement

Digital transformation requires organizations to adapt to technological developments so that their organizations can survive in the future. The aim of this research is to determine the impact of e-leadership and e-culture on work productivity through work engagement. The type of research used is associative research with a quantitative approach. The sampling technique uses simple random sampling technique. The samples in this research were employees in two technical implementation units under the Ministry of Law and Human Rights in the Bengkulu area, namely the Class IIB Bengkulu Women's Correctional Institution and the Class II Bengkulu Special Development Institution for Children. The total sample in this study was 120 employees. This research uses a questionnaire as the main method of data collection. The analysis method uses SEM-PLS. Based on research results, e-leadership has a positive and significant effect on work productivity with a t-value of 3.977 and a P-value of 0. E-leadership also has a positive and significant effect on work engagement with a t-value of 2.97 and P- value of 0.003. Furthermore, e-culture has a positive and significant effect on work productivity with a t-value of 2.326 and a P-value of 0.02. For the influence of e-culture on work engagement, the influence of work engagement on work productivity, the indirect influence of e-Leadership on work productivity through work engagement and the indirect influence of e-culture on work productivity through work engagement in this study were stated to not have a positive influence and significant.

Abstract 4582: HDAC6 inhibition reshapes the epigenome of cancer via P300 stabilization

Abstract Introduction: Histone deacetylases (HDACs)are crucial in regulating gene expression, DNA synthesis, and metabolic processes, including cancer, in various cellular environments. The unique structural and functional attributes of class IIb HDAC6 position it as a key player in influencing protein stability and chromatin dynamics. While its role in cancer progression and immunomodulation is well-recognized, the in-depth mechanisms following HDAC6 inactivation, particularly its influence on chromatin remodeling and gene regulation, are not thoroughly understood. This knowledge gap represents a critical area of investigation, given the potential of HDAC6 as a therapeutic target in oncology. This study aims to elucidate HDAC6 inactivation-dependent epigenetic effects of, exploring the possibility to exploit these latter for therapeutic purposes in cancer. This aim includes an examination of the stabilization of the lysine acetyltransferase P300 and its implications for chromatin structure and function. Methods & Results: In this study, ITF3756 and CRISPR/Cas9 were employed to inactivate HDAC6 across a variety of cancer cell lines (Jurkat, MDA 231, HCC1806, 4T1, and B16F10 melanoma). ATAC-seq and H3K27Ac ChIP-seq were used to investigate changes in chromatin accessibility, revealing significant alterations, particularly in introns and distal intergenic regions. Gene Ontology (GO) analysis further supported this alteration in the chromatin landscape, which indicated a differential expression of genes involved in critical cellular processes like cell proliferation, adhesion, migration, and apoptosis. A notable outcome of this study was the stabilization of P300 following ITF3756 treatment, an effect that was paralleled by changes in the expression of critical genes, including AKT1, ITGB3, GAS6, SOX9, NF1, TGFB2, and CASP7. These genes are integral to cellular survival mechanisms, and their modulation emphasizes the role of HDAC6 in cancer cell physiology. Conclusions: This research shows that the chemical or genetic inactivation of HDAC6 impacts cancer cell proliferation and chromatin architecture, underscoring the potential of HDAC6 as a target in cancer therapeutics.. A critical finding of this study is the stabilization of P300, which offers new perspectives on HDAC6's functionality and its role as an epigenetic modifier in cancer cells. This study contributes to the field by suggesting therapeutic strategies focusing on HDAC/HAT pharmacological targeting, thereby advancing our understanding of the role of HDAC6 in regulating cancer cell behavior and epigenetic landscape. Citation Format: Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni, Stella Gagliardi, Maria Garofalo, Gabriele Antonio Zingale, Irene Pandino, Diego Sbardella, Lina Cipolla, Simone Sabbioneda, Antonella Farsetti, Chiara Ripamonti, Gianluca Fossati, Christian Steinkühler, Sandra Atlante, Carlo Gaetano. HDAC6 inhibition reshapes the epigenome of cancer via P300 stabilization [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4582.

Safety and Feasibility of the BYCROSS® Atherectomy Device for the Treatment of Femoropopliteal Arterial Obstructions: Single-Center Short-Term Outcomes.

Background: Endovascular techniques have gained preference over peripheral arterial bypass surgery due to their minimally invasive nature; however, endovascular treatments often show limited efficacy in arterial segments with a high atherosclerotic load. The use of atherectomy devices enables the removal of calcified plaque material and may promote arterial wall remodeling. This study assessed the technical success, safety, and feasibility of the BYCROSS® atherectomy device in femoropopliteal lesions. Methods: This single-center, retrospective cohort study analyzed elective patients undergoing BYCROSS® atherectomy for chronic peripheral arterial disease from March 2022 to May 2023. Patient data, procedural details, and outcomes were retrospectively collected from electronic patient records. The primary performance endpoints of this study were technical success, complications, and patency rates. Primary safety endpoints included 30-day and short-term major adverse limb events (MALEs), major adverse cardiovascular events (MACEs), and mortality rate. Results: The study included 19 patients (median age, 71 years; 63% male) with Fontaine class IIb (26%), III (21%), or IV (53%). The BYCROSS® atherectomy device was used to treat 22 limbs in the femoropopliteal tract, of which 11 lesions (50%) were occlusions and 11 were stenoses, with a median length of 24 cm (interquartile range: 17-38). Technical success was achieved in all cases: 4.5% required atherectomy only, 50% required additional balloon angioplasties, 41% required balloon angioplasties and stenting, and 4.5% required segments only stenting. Additional treatment of below-the-knee arteries was performed in 12 patients. Procedurally related complications (not limited to the use of the BYCROSS® device) occurred in 23% of limbs, including distal embolization and laceration. At 30 days, mortality was 5%, the MACE rate was 11%, and the MALE rate was 0%. The observed mortality rate was not directly related to the procedure. Patency (<50% restenosis at duplex ultrasound) was 83% at 30 days. Conclusions: The use of the BYCROSS® atherectomy device for the treatment of femoropopliteal lesions appears to be safe and feasible, with high technical success and low MALE and MACE rates in a challenging population with long-segment femoropopliteal lesions. Long-term follow-up in larger patient series is needed to confirm these findings and to determine the durability of this technique.

Minimally invasive left atrial appendage occlusion plus reduced dose direct oral anticoagulant to prevent stroke in patients with atrial fibrillation-the LAAO-PlusRE.

The onset of atrial fibrillation (AF) has a direct association with left atrial appendage (LAA) function, as demonstrated by recent studies demonstrating the link between left atrial (LA) wall fibrosis, impaired contractility, and the development of AF. Non-valvular AF (NVAF) affects almost 30 million people worldwide, with this number expected to increase in the next 20 years. It is the main cause of ischemic stroke, with significant subsequent economic and social impact. Currently, the mainstay of stroke prevention in patients with NVAF is oral anticoagulation (OAC), which reduces the incidence of ischemic events at the stake of increased hemorrhagic events. Despite the introduction and widespread use of direct oral anticoagulants (DOACs), which almost completely replaced vitamin K antagonists (VKAs), the adherence to OAC is still low, hindering the efficacy of stroke prevention. Percutaneous LAA occlusion (LAAO) is now indicated (class IIB) in patients with NVAF at increased ischemic risk who cannot undergo OAC. Recently published data demonstrated that a reduced dose of DOAC after percutaneous LAAO is superior to long-term dual antiplatelet therapy (DAPT) for stroke prevention in the mid-term. One of the possible pitfalls of percutaneous LAAO is postprocedural peri-device leaks (PDLs) that have been associated with increased thromboembolic events. According to LAAOS III results, surgical LAAO during cardiac surgery brings a 33% reduction in risk of stroke at five years, independently from the OAC regimen with a high rate of complete appendage occlusion. The combination of surgical LAAO and reduced dose DOAC might ensure adequate embolic prevention, lowering the hemorrhagic risk. The present manuscript aims to describe the rationale and design of the Minimally Invasive Left Atrial Appendage Occlusion Plus REduced Dose DOAC To Prevent Stroke In Patients With Atrial Fibrillation Randomized Clinical Trial (LAAO-PlusRE).

Prophylactic Anticoagulation to Prevent Left Ventricular Thrombus Following Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

Clinical practice guidelines from the American Heart Association recommend consideration of prophylactic anticoagulation to prevent left ventricular thrombus (LVT) formation in anterior ST-elevation myocardial infarction (STEMI) patients. These guidelines were given a low certainty of evidence (Class IIb, Level C), relying primarily on case studies and expert consensus to inform practice. Our objective was to compare the safety and efficacy of prophylactic anticoagulation, in addition to dual antiplatelet therapy (DAPT), in the current era of timely primary percutaneous coronary intervention (pPCI). EMBASE, MEDLINE and Cochrane Library were systematically searched from January 2012 through June 2022. A total of 7,378 publications were screened, and 5 publications were eventually included in this review: 1 randomized control trial and 4 retrospective studies involving 1,461 patients. Data were pooled using a fixed effects model and reported as odds ratios (OR) with 95% confidence intervals (CI). The primary outcome of interest was the rate of LVT formation, and the secondary outcomes were the rate of major bleeding and systemic embolism. Pooled analysis showed a significantly lower rate of LVT formation (OR: 0.28 [95% CI: 0.11–0.73; p < 0.01]) and significantly higher rates of bleeding (OR: 2.85 [95% CI: 1.13–7.24; p= 0.03]) in the triple therapy (TT) group compared to DAPT. No significant difference was observed in the rate of systemic embolism between the groups (OR: 0.37 [95% CI: 0.12–1.13; p = 0.08]). In this meta-analysis, there is no conclusive evidence to either support or oppose the use of TT for LVT prevention in anterior STEMI patients treated with pPCI. Appropriately powered randomized controlled trials are warranted to further evaluate the benefits of LVT prevention against the risks of major bleeding in this population.

Enhanced Recovery After Surgery Cardiac Society turnkey order set for prevention and management of postoperative atrial fibrillation after cardiac surgery: Proceedings from the American Association for Thoracic Surgery ERAS Conclave 2023

BackgroundPostoperative atrial fibrillation (POAF) is a prevalent complication following cardiac surgery that is associated with increased adverse events. Several guidelines and expert consensus documents have been published addressing the prevention and management of POAF. We aimed to develop an order set to facilitate widespread implementation and adoption of evidence-based practices for POAF following cardiac surgery. MethodsSubject matter experts were consulted to translate existing guidelines and literature into a sample turnkey order set (TKO) for POAF. Orders derived from consistent class I or IIA or equivalent recommendations across referenced guidelines and consensus manuscripts appear in the TKO in bold type. Selected orders that were inconsistently class I or IIA, class IIB, or supported by published evidence appear in italic type. ResultsPreoperatively, the recommendation is to screen patients for paroxysmal or chronic atrial fibrillation and initiate appropriate treatment based on individual risk stratification for the development of POAF. This may include the administration of beta-blockers or amiodarone, tailored to the patient's specific risk profile. Intraoperatively, surgical interventions such as posterior pericardiotomy should be considered in selected patients. Postoperatively, it is crucial to focus on electrolyte normalization, implementation strategies for rate or rhythm control, and anticoagulation management. These comprehensive measures aim to optimize patient outcomes and reduce the occurrence of POAF following cardiac surgery. ConclusionsDespite the well-established benefits of implementing a multidisciplinary care pathway for POAF in cardiac surgery, its adoption and implementation remain inconsistent. We have developed a readily applicable order set that incorporates recommendations from existing guidelines.

Analysis of the Satisfaction of Narcotics Residents with Services at Nunukan Class IIB Correctional Facility

This research aims to examine the satisfaction level of narcotics prisoners regarding the services provided at the Class IIB Nunukan Penitentiary. The research employs a qualitative research method, utilizing interview and literature review techniques. The data analysis technique utilized is qualitative data analysis, involving data presentation, data verification, data reduction, and the re-presentation of the reduced data. The results of the study indicate that inmates at Class IIB Nunukan Penitentiary are pleased with the caregiving and medical services that meet the standards of Law No. 12 of 1995. However, the service delivery faces hindrances such as budget constraints, inadequate facilities, limited transportation, and insufficient staff. Additionally, surveys and interviews reveal issues related to the non-objectivity and lack of empathy from officers, as well as insufficient communication between officers and inmates. Keywords: Satisfaction, Service, Prisoners, Correctional Institutions

Association of indications for mandibular third molar coronectomy and the Pell and Gregory and the Winter classification systems

PurposeThe purpose of this study was to determine how the surgeon’s decision to perform a mandibular third molar coronectomy or surgical removal is associated with the impaction pattern as classified using Pell and Gregory or Winter’s system.MethodsThis observational, cross-sectional study was conducted on 813 mandibular third molars belonging to 565 patients. All patients were referred for removal of the mandibular third molar and had radiographic signs indicating a close relationship with the inferior alveolar nerve. Panoramic images were classified according to the impaction pattern.ResultsA coronectomy was performed on 492 (60.5%) mandibular third molars.Most impacted mandibular third molars were class IIB with a mesioangular inclination. A significant association was found between the Pell and Gregory classification and the surgeon’s choice (p = 0.002). Winter’s classification was not significantly associated with surgeon choice (p = 0.425).ConclusionMandibular third molar coronectomy is chosen more frequently than surgical removal if molars are class III and position B.Trial registration numberNot applicable.

Response to MHC-based olfactory cues in a mate choice context in two species of darter (Percidae: Etheostoma).

Mate choice is hypothesized to play an important role in maintaining high diversity at major histocompatibility complex (MHC) genes in vertebrates. Many studies have revealed that females across taxa prefer the scent of males with MHC genotypes different to their own. In this study we tested the "opposites-attract" hypothesis in two species of darter with known differences in female criteria used in mate choice: in the fantail darters (a paternal-care species), females prefer males with visual traits related to nest guarding and egg tending, while in rainbow darters (not a paternal-care species) female mate choice criteria are unknown. In dichotomous mate-choice trials, we presented females of both species with the scents of conspecific males with MHC class IIb genotypes that were either similar or dissimilar to that of the focal female. We evaluated the proportion of time each female spent with each male and calculated the average strength of female preference for both species. Female fantail darters demonstrated a preference for the scent of males with similar (rather than dissimilar) MHC genotypes, but this result was not statistically significant. Rainbow darter females showed no preference for the scent of males with similar or dissimilar MHC genotypes. Our results do not support the "opposites-attract" hypothesis in darters.

INHERITANCE RIGHTS OF OUTSIDE MARRIAGE DESCENDANTS AFTER THE RULING OF THE CONSTITUTIONAL COURT NUMBER 46 OF 2010

The aim of this research is to find out. Based on the background description above, a problem can be drawn, namely: How is the organizational performance of the Class II B Kudus State Detention Center implemented in improving public services and what are the obstacles that occur in implementing the organizational performance of the Class II B Kudus State Detention Center in improving public services? This research uses a sociological juridical approach. Sociological juridical approach, namely a research approach that examines the legal perceptions and behavior of people (humans and legal entities) and society as well as the effectiveness of the enactment of positive law in society. Implementation of the performance of the Class II B Kudus Prison in improving public services is reflected in the decision to accept prisoners, even though its main function is accepting prisoners. This is due to the unique situation in Kudus Regency which does not yet have a prison, forcing the Class IIB Kudus Detention Center to adapt and meet public needs in the criminal justice system. As a result, the detention center not only handles detainees but also inmates, having a broader impact on the criminal justice system and Kudus Regency society in general. This statement also highlights the relationship between legal structure, legal substance and legal culture in the context of public services

The Effect of Supportive Therapy in Reducing Anxiety in Juvenile Inmates in Class IIb Correctional Institutions, Purwakarta Regency, Indonesia

Anxiety is a mental health problem that is often experienced by teenagers, including juvenile inmates. Supportive therapy is one intervention that can be used to reduce anxiety in adolescents. This study aims to determine the effect of supportive therapy on reducing anxiety in juvenile inmates at the Class IIb Correctional Institution, Purwakarta Regency, Indonesia. This research uses a quasi-experimental design with a pretest-posttest control group design. The research sample consisted of 30 juvenile inmates who were divided into two groups, namely the intervention group (15 people) and the control group (15 people). The intervention group was given supportive therapy for 4 weeks, while the control group was given no intervention. The results of the study showed that there was a significant reduction in anxiety in the intervention group after being given supportive therapy. The average level of anxiety in the intervention group before the intervention was 2.67 (SD=0.488), while after the intervention, it was 1.53 (SD=0.516). This difference is statistically significant (p&lt;0.001). Based on the results of this research, it can be concluded that supportive therapy can reduce anxiety in juvenile inmates. Supportive therapy can help juvenile inmates understand and address the causes of their anxiety, as well as increase their ability to use adaptive coping resources.