Three-phase four-leg voltage-source inverter has been extensively investigated in recent years for its compactness, small size, and high efficiency, and it has been proved to be the best solution for providing transformer-less neutral connection to three-phase asymmetric loads. The main purpose of this article is to apply 3-D unbalanced coordinate transformation to the four-leg inverter, which supplies stand-alone asymmetric loads, to maintain the balance of the output capacitor voltages, and obtain simpler control structure and better control performance. First, a double closed-loop PI control structure can be designed based on the Clarke and Park transformations. Second, the phases and amplitudes of the capacitor voltages are locked based on the 3-D unbalanced coordinate transformation. Furthermore, the Clarke transformation oriented on the inductor currents is replaced by a 3-D unbalanced coordinate transformation, and the corresponding unbalance indices are continuously adjusted according to the unbalance indices of the capacitor voltages, so as to recover the capacitor voltages to the balanced condition. The simulation and experimental results of the whole control system for the four-leg inverter are provided in the end, so as to verify the feasibility and effectiveness of the 3-D unbalanced coordinate transformation for application to the power electronic systems.