This research article investigates the effect of meteorological changes on the comfort of residents in Imo State, Nigeria, which is situated in a tropical monsoon climate. The study aims to assess the state of the indoor environment in residential buildings in Imo State, considering thermal changes caused by meteorological variations. A case study approach was adopted, focusing on a selected residential building in Umuasonye, Orji, Owerri North, Imo State. The study spanned a period of 10 years, from 2011 to 2021, and included physical observation, measurement, and qualitative analysis of the collected data. A case study approach was employed to overcome limitations in accessing a large sample size of individual residential buildings. The selected residential building in Umuasonye, Orji, Owerri North, Imo State served as a representative example for the study. Data collection involved physical observation, measurement, and qualitative analysis over a 10-year period, from 2011 to 2021. This approach allowed for a comprehensive understanding of the indoor environment and its relationship with meteorological changes. Findings reveal significant climate and weather changes in Imo State, leading to thermal variations in building spaces. The study assesses the impact on resident comfort and identifies adaptive strategies employed. During dry seasons, residents utilized cooling systems, ventilation, and reduced hot water usage. In wet seasons, measures such as closing windows, wearing thick clothing, and increased hotwater usage were observed. This research provides valuable insights into the impact of meteorological changes on resident comfort in Imo State, Nigeria. It highlights the importance of climate-responsive building design and systems, showcasing adaptive strategies employed by residents. The case study approach contributes to knowledge for architects, building industry stak eholders, and users interested in promoting climate-responsive buildings and systems