The article examines the effectiveness of communication practices in modern international relations against the background of civilizational features of the interacting parties. The authors found out the actual state and nature of communications at the international level between the East and the West, they discovered the causes of conflict, and formed a conclusion on this basis. The researchers answered the question - how to reach a new level of effectiveness of communication practices in international relations and how to achieve congruent communications in the intra-societal system? The purpose of the article is to clarify modern effective communication practices taking into account the inter-civilization factor in international relations. The relevance of the article lies in the need to search for new approaches in international communications based on the synergy of communications to solve global problems of our time, create safe living conditions for the world community. As a result of the study, the authors revealed the ineffectiveness of modern communication practices. This statement is true for both international communications and communications in the internal environment of political, intra-societal systems. The subjects of international relations often simply do not take into account the civilizational differences of their partners, therefore they cannot come to an agreement with them on important issues of life, first of all. Among these differences, we should highlight: cultural, ethnic and religious characteristics of communicants - representatives of the East and the West. Modern international conflicts arising on the basis of civilizational and cultural confrontations between the East and the West push us to develop a new paradigm of communication practices. These practices should be based on congruent interaction of communicants, on the elimination of their civilizational and cultural differences as the cause of unsuccessful communications. Politicians are now forced to take into account not only the political, economic and power resources of the interacting parties, but also cultural, religious and ethnic characteristics. The focus of researchers should be on issues that include not only minimizing disagreements and balancing interests between states, but also searching for the broadest possible agenda and identifying common interests at the global and regional levels.