ABSTRACT Background Major sporting events are associated with violence, creating societal and healthcare system burdens. However, these associations have not been objectively evaluated in low- and middle-income countries, where resources for violence prevention and injury control are limited. The objective of this study was to determine whether the days of football events were associated with changes in homicide rates in Cali, Colombia. Study design Ecologic study conducted during 2005 to 2008 using a time-series design. Football days were those in which the city's professional teams or the national team played nationally or internationally (279 days). Daily counts of homicides were obtained from the city's fatal injury surveillance system. Homicide rates were computed using population estimates to adjudicate person-years of exposure. In stepwise conditional autoregressive negative binomial regressions adjusted for victims’ demographics, known sociopolitical and cultural factors, weekends, holidays, trends and seasonality, homicide rates during football days were compared against homicide rates during non-football days. Results There were 1,352 homicides during football days and 4,767 homicides during non-football days (rate, 82 and 68 per 100,000 person-years respectively, p < 0.001). There was an increased risk of homicides during home game days (IRR 1.11, 95%CI 1.01-1.21, p = 0.022) compared to non-football days. There was an increased risk of homicides during the day after football game (IRR 1.08, 95%CI 1.00-1.16, p = 0.041) compared to other days. The outcome of the games was not statistically significantly associated with increased risk of homicides. Conclusion This analysis suggests that football days were associated with increased risk of homicides in Cali, Colombia. Violence prevention and injury control efforts should be increased on days of home games and on the next day after football. The healthcare system should allocate and optimize resources these days, given the increased demand for trauma care. Educational and preventive civic interventions should be instituted around these events. How to cite this article Sánchez ÁI, Krafty RT, Puyana JC, Gutiérrez MI. Football Events and Their Association with Interpersonal Violence Deaths. Panam J Trauma Critical Care Emerg Surg 2013;2(1):26-32.