Asphalt concrete pavement, as the main form of high-grade roads today, occupies an important place in modern road construction due to its advantages such as low noise level, ease of repair and short construction period. This road type is widely adopted worldwide and provides a reliable foundation for road networks in cities and villages. In cold regions, snowy weather tends to cause ice on the road surface, posing a serious safety hazard for vehicle travel. The problem of road accidents in winter is relevant both for regions with extremely cold climatic conditions and for the temperate continental climate that prevails almost throughout Ukraine. To solve this problem, deicing agents are widely used to improve the safety of road travel. The application of deicing agents effectively reduces the impact of snow and ice on roads and ensures the safe passage of vehicles in adverse weather conditions. However, while deicing agents play an important role in improving traffic flow, their widespread use has also brought some problems that should not be ignored. The chemicals in deicing agents may have adverse effects on pavement materials, especially on asphalt concrete roads. For studying the effect of deicing agents on asphalt concrete, this paper presents an experimental investigation of the effect of deicing agents on the water stability of asphalt concrete under the conditions of freeze-thaw cycle test. The impact of deicing agents and freeze-thaw cycles on asphalt concrete was investigated by evaluating the variation patterns of three key parameters: stability, residual stability and air void content. The experimental results showed that the stability and residual stability of asphalt concrete showed an overall decreasing trend with the increase of the number of freeze-thaw cycles, indicating that the asphalt concrete was damaged or degraded under the conditions of freeze-thaw cycles. The higher concentration of the deicer solution corresponded to the more pronounced changes in the test parameters, indicating a significant effect of the deicer on the asphalt concrete. At the end of 27 cycles, the average loss of stability, residual stability and void ratio were 29%, 22% and 73%, respectively. This indicates that the combined effect of freeze-thaw cycles and deicing agent is more significant for air void content.