Objectives: A growing global health concern is chronic kidney disease (CKD), which isprevalent in Saudi Arabia as well. In this research, we aimed to assess the knowledge,Perception, and Attitude toward Chronic Kidney Disease among the General Populationin Makkah, Saudi Arabia.Methods: In Makkah City, Saudi Arabia, a cross-sectional survey was carried out in2023. A random sample of the general population aged 18 to 60 was given an onlinequestionnaire; individuals with CKD and healthcare professionals were not included.Results: The study's findings showed that 73.6% of participants had little or noawareness of chronic kidney disease (CKD), suggesting that the public had a poorcomprehension of the condition. Being young, unmarried, and having a family history ofrenal disease were all positively correlated with higher awareness levels.Conclusion: The study emphasizes the urgent need for public health measures, such aseducation and awareness campaigns, to raise public understanding of chronic kidneydisease (CKD) in Makkah, Saudi Arabia.Keywords: Chronic Kidney Disease (CKD), Makkah, Online questionnaire, Survey,Public awareness.