Background: Poor patient adherence to the treatment regimen is a major cause of treatment failure and of the emergence of drug-resistant TB. Present study was conducted to study clinico-epidemiological profile and adherence to anti tubercular treatment among tuberculosis patients.Methods: It was a cross sectional study done among 462 tuberculosis patients visiting G. G. Rathi Tuberculosis hospital during period January 2020 to April 2020.Results: Out of total 462 study subjects 268 (58%) were male and 194 (42%) were female. Most of i.e. 143 (30.9%) were from age group 41-50 years. majority i.e. 148 (32.0%) were educated up to secondary school. As per Morisky medication adherence scale-4, majority 325 (70.4%) study subjects were having high adherence.Conclusions: About 8% of the patients were having low adherent. Age and education of study subject was found to be significantly associated with adherence.