Urbanisation in the cities of Sub-Saharan Africa has been associated with urban sprawl and increased vehicular traffic, which undermine the agglomeration effects of the cities on socioeconomic development. These adverse effects will exacerbate as the human population of the region continues to increase. Some scholars argue that making the cities mobility-smart could mitigate the adverse effects of urbanisation in the region. However, the conventional literature on smart mobility in Sub-Saharan Africa does little to demonstrate how the concept can be applied. In this regard, the purpose of this study is two pronged: a) to assess the mobility smartness of Ghanaian cities and b) to demonstrate how the concept can be operationalised to mitigate some of the adverse effects of urbanisation in the cities. The research process began with a review of relevant literature to conceptualise smart mobility. The conceptual framework was then used to assess the mobility-smartness of Ghanaian cities, which was followed by a discussion of how the concept of smart cities can be operationalised in Ghanaian cities. The results show that the cities in Ghana, like many cities in Sub-Saharan Africa, depend mainly on the road sub-sector for the movement of people and freight. The rapid increases in vehicular population without a commensurate expansion in road infrastructure have undermined the cities’ productivity. The conclusion from this is that the cities are not mobility-smart and for this to change, the paper argues that efforts should be made to improve people mobility, information logistic mobility and information mobility. These require technological literate and receptive population and investments in transport infrastructure.