CiteSpace Software Research Articles

Integrative Multi-omics and Big Data Analysis of Global Nutrition and Radiotherapy Trends: A Bibliometric Approach

BackgroundRadiotherapy serves as a crucial modality in cancer treatment, frequently synergizing with other therapies to enhance patient outcomes. Unfortunately, radiotherapy is often accompanied by nutritional impairments, including dysphagia and malnutrition, which hinder patient recovery and treatment efficacy. Moreover, nutritional abnormalities accompanied by metabolic reprogramming may lead to alterations across multiple omics domains. Consequently, big data analysis on radiotherapy and nutrition is imperative. ObjectiveThis study employs bibliometric analysis to visually showcase the current research landscape and trending hotspots in the intersection of nutrition and radiotherapy. MethodsLeveraging the Web of Science Core Collection, we screened and analyzed 4,379 publications related to nutrition and radiotherapy published between 2004 and 2023. Utilizing VOSviewer, Bibliometrix, and Citespace software, we conducted bibliometric analysis and visualization of countries, institutions, authors, and keywords. ResultsOur analysis reveals a substantial increase in publications concerning nutrition and radiotherapy, with the United States and China leading in both publication volume and citation impact. The research focus has gradually shifted from phenomenological studies to mechanistic investigations, as evidenced by changes in keyword usage. While confirming the influence of nutritional status on radiotherapy outcomes, we also identified potential links to genomics, proteomics, metabolomics, and other omics disciplines. ConclusionThis study emphasizes the growing attention to the interplay between nutrition and radiotherapy in cancer treatment. Our findings suggest that further integration of multi-omics analysis can enhance understanding of the mechanisms underlying these interactions, providing a foundation for advancing cancer diagnosis and treatment strategies in the future.

Emerging trends and hotspots in intestinal microbiota research in sepsis: bibliometric analysis

BackgroundThe association between the gut microbiota and sepsis has garnered attention in the field of intestinal research in sepsis. This study utilizes bibliometric methods to visualize and analyze the literature on gut microbiota research in sepsis from 2011 to 2024, providing a scientific foundation for research directions and key issues in this domain.MethodsOriginal articles and reviews of gut microbiota research in sepsis, which published in English between 2011 and 2024, were obtained from the Web of Science Core Collection on June 21, 2024. Python, VOSviewer, and CiteSpace software were used for the visual analysis of the retrieved data.ResultsA total of 1,031 articles were analyzed, originating from 72 countries or regions, 1,614 research institutions, and 6,541 authors. The articles were published in 434 different journals, covering 89 different research fields. The number of publications and citations in this research area showed a significant growth trend from 2011 to 2024, with China, the United States, and the United Kingdom being the main research forces. Asada Leelahavanichkul from Thailand was identified as the most prolific author, making him the most authoritative expert in this field. “Nutrients” had the highest number of publications, while “Frontiers in Cellular and Infection Microbiology,” “Frontiers in Immunology” and “the International Journal of Molecular Sciences” have shown increasing attention to this field in the past 2 years. Author keywords appearing more than 100 times included “gut microbiota (GM),” “sepsis” and “microbiota.” Finally, this study identified “lipopolysaccharides (LPS),” “short-chain fatty acids (SCFAs),” “probiotics,” “fecal microbiota transplantation (FMT)” and “gut-liver axis” as the research hotspots and potential frontier directions in this field.ConclusionThis bibliometric study summarizes current important perspectives and offers comprehensive guidance between sepsis and intestinal microbiota, which may help researchers choose the most appropriate research directions.

The pyroptosis and fibrotic diseases: a bibliometric analysis from 2010 to 2024.

Fibrosis is the ultimate, common pathological ending of most chronic inflammatory diseases and increases the chances of developing life-threatening illnesses. Pyroptosis, a newfound form of lytic programmed cell death initiated by the inflammasome, has received more and more attention because of its association with fibrotic diseases. Therefore, this study visualizes the connection between pyroptosis and fibrosis research through bibliometric methods, aimed at providing global research hits and tendencies in the field. We collected and analyzed the articles on pyroptosis and fibrosis from 2010 to 2024 via Web of Science. Visual data analysis was performed for countries, institutions, authors, references, and keywords in the field using VOSviewer, CiteSpace software, the "Bibliometrix" R package, the bibliometric website ( https://bibliometric.com/ ), and Excel software. We analyzed the data by utilizing the bibliometric review method. A total of 566 articles and reviews relating to pyroptosis and fibrosis were identified in the Web of Science. The number of publications in the domain has continued to grow since 2010. These scientific outputs were mainly from 129 countries/regions and 1919 institutions, particularly China (n = 423) and the USA (n = 83). More importantly, although China publishes a vast majority of articles, its centrality is lower than that of the USA (0.59 vs 0.61). Among the 3833 authors involved in this field, Feldstein, A. E. is the most prolific author. Shi, J. J. is the world's most-cited author among the 12,143 authors in these academic journals. Frontiers in Immunology was a prolific contributor, and Nature was the most frequently cited journal. After analysis, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death were the top-cited articles. The analysis of keywords displayed that pyroptosis, fibrosis, and pathways were the main research hotspots and frontier directions in recent years. We analyzed the characteristics of published articles and drew a fundamental knowledge structure on pyroptosis and fibrosis research via bibliometric analysis. The potential mechanism between fibrosis and pyroptosis is deeply tied to the current moment. Our findings can help researchers make clear the research status and value of fibrosis and pyroptosis and provide new directions for future research as soon as possible.

Research hotspots and evolution trends of food safety risk assessment techniques and methods

AbstractFood safety incidents frequently occur in China and other countries. Food safety risk management has evolved from harm‐based to risk‐based approaches to control risks more scientifically and effectively. Risk assessment is at the core of risk control and provides a scientific basis for the development of risk management measures. Therefore, analyzing the research status and development trends of food safety risk assessment technologies and methods is important for improving food safety risk assessment and risk management. In this study, CiteSpace software was used to analyze a knowledge graph of popular research topics in the field of food safety risk assessment over the past 14 years, identify research keywords, and provide centrality statistics. Food safety risk assessments primarily focus on in vitro high‐throughput testing, computational toxicology, predictive microbiology, mechanistic research, and other technical methods. In the future, international coordination, cooperation, and cross‐integration of relevant disciplines should be strengthened, and research on and application of innovative technologies for food safety risk assessment should be promoted. Research on food safety risk assessment technologies and methods is in an active development stage and has good prospects for further exploration and application.

Global research trends in traditional Chinese medicine therapy for acute leukemia: a comprehensive visualization and bibliometric analysis

ABSTRACT Background: The application of traditional Chinese medicine (TCM) therapy to acute leukemia has been intensively investigated. However, the bibliometric analysis in this field has not been performed. This bibliometric study aimed to comprehensively analyze the research trends and active areas of TCM therapy for acute leukemia from 2000 to 2023. Methods: We searched articles and reviews published between 2000 and 2023 that discussed TCM in acute leukemia from the Web of Science Core Collection (WoSCC). Knowledge mapping and bibliometric analysis were conducted using VOSviewer, CiteSpace software, and R-bibliometrix. Results: A total of 1,099 articles were included, with China, the United States, and Korea contributing the most papers. Most papers were published in the Journal of Ethnopharmacology. Meanwhile, China saw a steady increase in the number of publications. The three leading institutions that made outstanding contributions were the China Medical University, the Chinese Academy of Sciences, and the China Academy of Chinese Medical Sciences. Efferth Thomas, Liu Wei, and Liu Jie were the top three productive authors, with Efferth T receiving the most co-citations. The most frequently cited reference was Shen ZX (1997). In the analysis of keywords co-occurrence, ‘survival,’ ‘risk factors,’ ‘nanoparticles,’ and ‘metabolism’ are the active research topics. Conclusion: This bibliometric study provides researchers with a comprehensive overview and significant value in understanding the development of TCM in acute leukemia treatment.

Visual analysis of patient safety research hotspots and trends in the context of telemedicine based on Web of Science.

To analyze the research status, hotspots, and trends of patient safety in the context of international telemedicine, and to provide reference for future research in various countries. The literature pertaining to patient safety within the realm of telemedicine was systematically retrieved from the Web of Science core collection database, encompassing the period from January 2010 to December 2023. Visual analysis of publication quantity, primary authorship, and keyword trends was conducted using CiteSpace (6.2R6) software. The geographical distribution of research focus was visualized through VOSviewer software and SCImago Graphica software, while research institutions were depicted using VOSviewer software and Highcharts software. Data organization was facilitated by Excel 2019 software. A total of 5356 related articles were included, and the number of published papers showed an overall upward trend, and the countries and institutions with the largest number of papers were the United States and Harvard University, respectively, and a stable core author research population had not yet been formed in this research field. Through keyword analysis, it can be seen that the research hotspots mainly focus on the research on the influencing factors of patient safety in the context of telemedicine, the research on the application value of telemedicine, and the research on coping strategies that affect patient safety. The research on patient safety in the context of telemedicine in foreign countries has a certain depth and breadth, which has important reference significance for improving the medical quality and patient safety of Internet hospitals in various countries.

Sustainability accounting research over three decades: A scientometric meta‐analysis

AbstractAs organizations worldwide face increasing pressure to integrate sustainability into their core principles, the need for robust sustainability accounting practices has never been more crucial. This study takes on the challenge by mapping out the intellectual structure of sustainability accounting research domain. Using a mix of scientometric analysis of 1702 articles and in‐depth content analysis of 122 key works spanning more than 30 years from 1991 to 2024, the study unveils the past, present, and future of this vital field. Intricate domain visualizations were created utilizing CiteSpace software revealing networks of co‐authorship, keywords, subject categories, institutions, and countries committed to research on sustainability accounting, including co‐citation and cluster analysis. Results revealed research production concentrated in developed nations, highlighting the urgency for increased focus on this topic within developing and emerging countries. The network structure indicated a scarcity of global collaboration particularly at the company level. The central themes of sustainability accounting, identified through cluster analysis and examination of highly co‐cited documents, encompass sustainability management accounting, life cycle assessment, carbon accounting, national accounts, climate policy, and ecosystem accounting, playing a significant role in shaping its landscape and ongoing evolution. Six relevant emerging themes were identified from in‐depth content analysis of recent literature in the management domain, comprising the role of accountants in mitigating climate risk, rethinking accounting for planetary boundaries, biodiversity loss and extinction accounting, sustainability assurance, technological advancements, and other miscellaneous themes. This study carries significant implications for a diverse array of stakeholders, including policymakers, organizations, society, and academics.

Research progress of wearable devices in textile field: a bibliometric analysis using VOSviewer, RStudio bibliometrix and CiteSpace software tools

PurposeThe purpose of this paper is to analyze research trends on “Wearable devices in textile filed” from 2010 to 2023 and determine the important keywords, nations and journals associated with this topic.Design/methodology/approachUtilizing journal literature on wearable devices from the 2010 to 2023 Web of Science (WoS) database, this study employs VOSviewer, biblioshiny of the R software package and the specialized software CiteSpace to generate knowledge graphs for measuring retrieval outcomes.FindingsThe research on wearable devices integrated into textiles between 2010 and 2023 can be divided into three stages: initial slow progress, subsequent rapid advancement and final slow progress, indicating a general rise in the quantity of published material. The terms “fabrication,” “wearable electronics” and “design” are closely linked in this field. China is the most globally networked country in this field, according to the World Collaboration Map. NANO ENERGY ranked first in the number of articles published in journals, with 18 articles and 1,151 citations.Originality/valueThe study identified the present state and research trends in the field of “Wearable devices in textile filed,” offering valuable information for researchers to enhance their understanding of the field’s progress.

A Bibliometric Analysis of STEM Education for Undergraduate Level Based on CiteSpace Software

This study aims to review the STEM education intervention on the undergraduate level by applying CiteSpace software, an innovative tool for bibliometric analysis and visualization. The Web of Science (WOS) database was used and covers the period from January 2008 to August 2023. Based on keyword search, seven clusters with the largest research volume in the past 15 years were identified and analysed with relevant literature. The results revealed that the trending topics of STEM education research included racial and gender differences in STEM education, reform of STEM education assessment and motivation methods for undergraduates, strategies to improve STEM academic performance, and the impact of STEM education on undergraduate employment. Furthermore, a cluster analysis of keywords and references was conducted to explore the connections between the clustered themes and the core theme of STEM. The timeline visualization diagram was used to examine the duration and evolution of each research theme in STEM education, which provided useful information for identifying the direction of STEM research. Finally, through the citation burst analysis, the top 15 most cited references were determined, and the STEM research hotspots were discussed in relation to their literature, which were consistent with the STEM research hotspots derived from the high-frequency themes and node literature. The findings of this study offer important insights into the development trend of STEM education and provide an evidence base and reference for future research and development of STEM education particularly at the undergraduate level.

A bibliometric analysis of acupuncture for Parkinson's disease non-motor symptoms from 2003 to 2023.

Parkinson's disease non-motor symptoms (PD-NMS) significantly affect patients' quality of life. Acupuncture has emerged as a potential complementary therapy for PD-NMS. This study aims to investigate general research status, hotspots and trends of acupuncture as a treatment for PD-NMS. Literature on Web of Science Core Collection (WoSCC) from 2003 to 2023 was retrieved, and bibliometric analysis was conducted using VOSviewer and CiteSpace software. 159 publications by 894 authors from 37 countries, 300 institutions, and 96 journals were retrieved and analyzed. The number of publications in this field is generally on the rise yearly. China was the leading contributor with 57 publications, and the United States followed with 36 publications and had the highest total citation count of 1562. Guangzhou University of Chinese Medicine ranked the highest with a total of 12 publications, while Harvard University had the highest average citation rate of 70 citations per publication. Evidence-Based Complementary and Alternative Medicine was the most prolific journal with 11 articles that had accumulated 122 citations. Park Hi-Joon was the leading contributor with seven articles and 314 citations. The keyword analysis highlighted emerging areas of interest like "deep brain stimulation" and "alpha-synuclein". Different countries, institutions, and authors should enhance cooperations, and the underlying mechanisms of acupuncture for PD-NMS should be demonstrated. This study will be helpful for better understanding the current knowledge and gaps in the areas of acupuncture as a treatment of PD-NMS.

Scientometric Analysis of Water Ecology Research: Insights from Chinese Ocean Universities

In response to increasing concerns about water ecology sustainability, this paper employs scientometric analysis to examine research trends at seven leading Chinese ocean universities from 2010 to 2021. Using CiteSpace software to analyze data from the Web of Science, we explored a comprehensive dataset of dissertations and published papers across disciplines such as water ecology, marine biology, fisheries, and environmental sciences. Our analysis shows a significant rise in research output after 2016, highlighting the pivotal role these universities play in advancing water ecology research. Through keyword co-occurrence and clustering analyses, we identified shifting research focuses, ranging from biodiversity and ecosystem dynamics to emerging topics like water quality management and ecological restoration. This study not only consolidates existing research achievements but also provides valuable insights for shaping future research directions in water ecology.

Knowledge mapping and research trends of brain-computer interface technology in rehabilitation: a bibliometric analysis.

Although the application of brain-computer interface (BCI) technology in rehabilitation has been extensively studied, a systematic and comprehensive bibliometric analysis of this area remains lacking. Thus, this study aims to analyze the research progress of BCI technology in rehabilitation through bibliometric methods. The study retrieved relevant publications on BCI technology in rehabilitation from the Web of Science Core Collection (WoSCC) between January 1, 2004, and June 30, 2024. The search was conducted using thematic queries, and the document types included "original articles" and "review articles." Bibliometric analysis and knowledge mapping were performed using the Bibliometrix package in R software and CiteSpace software. During the study period, a total of 1,431 publications on BCI technology in rehabilitation were published by 4,932 authors from 1,281 institutions across 79 countries in 386 academic journals. The volume of research literature in this field has shown a steady upward trend. The United States of America (USA) and China are the primary contributors, with Eberhard Karls University of Tübingen being the most active research institution. The journal Frontiers in Neuroscience published the most articles, while the Journal of Neural Engineering was the most cited. Niels Birbaumer not only authored the most articles but also received the highest number of citations. The main research areas include neurology, sports medicine, and ophthalmology. The diverse applications of BCI technology in stroke and spinal cord injury rehabilitation, as well as the evaluation of BCI performance, are current research hotspots. Moreover, deep learning has demonstrated significant potential in BCI technology rehabilitation applications. This bibliometric study provides an overview of the research landscape and developmental trends of BCI technology in rehabilitation, offering valuable reference points for researchers in formulating future research strategies.

Biomarkers and Alzheimer's disease: a bibliometric analysis.

The diagnosis and treatment of biomarkers in Alzheimer's disease has emerged as a prominent topic within Alzheimer's disease research. In this paper, we conducted a bibliometric analysis of data from a wide range of literature in this field to enhance the in-depth understanding of this area. The core collection of the Science Citation Index database (web of science) was used to search for relevant literature in the above fields from 1 January 2006 to 14 November 2022 and Citespace software was used to visualize and analyze the literature data. A total of 1,138 papers were included, of which the United States ranked first with 607 papers and China ranked 6th in the world with 84 papers. The value of mediational centrality is 0.49 in the United States and 0.05 in China. In terms of the number of articles published by the research authors, the Swedish scholar Blennow Kaj ranks first with 82 articles published, and the scholars who rank second and third are Zetterberg Henrik (78 articles) and Morris John C (64 articles), respectively; in terms of the mediational centrality, the American scholar Trojanowski John Q ranked first in the world with 0.1, and the second and third ranked scholars were Blennow Kaj (0.09) and Zetterberg Henrik (0.06) respectively. Scholar JACK CR ranked first with 377 citation frequency. The journal NEUROLOGY is ranked first with 943 citations. In recent years, global research in the field of biomarkers related to Alzheimer's disease has shown signs of softening, and the momentum of research has slightly diminished. However, this trend does not imply a decline in the quality of research. It is essential to enhance collaboration among countries, major research institutions, and scholars, with a particular emphasis on fostering international partnerships in the future.

A Scientometrics Analysis of Global Research on Social Media: Trends, Influential Works, And Future Directions Explored

This research aims to study regulations on the use of social media around the world. This study uses a qualitative scientometric approach. The data source for this study was taken from the Scopus Database with the keywords "Social Media Use" and "Policies." There were 173 documents analyzed, and the data was filtered using bibliometrics based on keyword relevance, author country, and year of publication, which was limited to 2018-2022. Citespace software was used to process the data stored in RIS format. The study found that, firstly, 173 publications were addressing social media use and policy from 2018 to 2022. Second, the most published publications in the United States are 73; third, ten authors have collaborated in research on social media use and policy. The study also found that the social media use and policies of governments and countries worldwide continue to evolve as technology advances and people's behavior changes. Governments should make appropriate regulations and make good use of social media to communicate with the public and achieve their goals.

Research Trends and Hotspots of Big Data in Ophthalmology: A Bibliometric Analysis and Visualization

ABSTRACT Purpose The burst of modern information has significantly promoted the development of global medicine into a new era of big data healthcare. Ophthalmology is one of the most prominent medical specialties driven by big data analytics. This study aimed to describe the development status and research hotspots of big data in ophthalmology. Methods English articles and reviews related to big data in ophthalmology published from January 1, 1999, to April 30, 2024, were retrieved from the Web of Science Core Collection. The relevant information was analyzed and visualized using VOSviewer and CiteSpace software. Results A total of 406 qualified documents were included in the analysis. The annual number of publications on big data in ophthalmology reached a rapidly increasing stage since 2019. The United States (n = 147) led in the number of publications, followed by India (n = 77) and China (n = 69). The L.V. Prasad Eye Institute in India was the most productive institution (n = 50), and Anthony Vipin Das was the most influential author with the most relevant literature (n = 45). The electronic medical records were the primary source of ophthalmic big data, and artificial intelligence served as the principal analytics tool. Diabetic retinopathy, glaucoma, and myopia are currently the main topics of interest in this field. Conclusions The application of big data in ophthalmology has experienced rapid growth in recent years. Big data is expected to play an increasingly significant role in shaping the future of research and clinical practice in ophthalmology.

Research hotspots and emerging trends in growth and development of macrofungi: a bibliometric review based on CiteSpace analysis.

Macrofungi (or mushrooms) are essential for agriculture, food, and ecology. Although research on the growth and development of macrofungi (GDM) can provide insights into their biological characteristics and metabolite synthesis mechanisms, further exploration is needed for a systematic and visual analysis of the current research progress on GDM. To comprehensively understand the research status and development trend of GDM, a total of 545 scientific literature related to GDM in the Web of Science Core Collection database from 2008 to 2024 were searched and selected as research objects. The general information (publication year, country, institution, and cited journal) and the specific information (co-authorship, keyword co-occurrence, and references with strong citation bursts) were mined and visualized in detail based on CiteSpace software. These analyses demonstrated that related research is still fashionable, and China is dominant and influential in this field. More frequent and in-depth cooperation among authors, institutions and regions is conducive to promoting the research on GDM. Additionally, the quantity and cluster analyses of keywords and references demonstrated that medicinal/edible macrofungi and sustainable development (e.g. mushroom substrate reuse) may be research hotspots and will remain popular in the coming years. This research aims to supply researchers with up-to-date knowledge and cutting-edge issues related to GDM by providing a visually appealing representations on quantitative GDM studies.

A bibliometric analysis of bladder cancer and microRNA research: Trends and advances from 2008 to 2022.

Bladder cancer (BC) is a significant global health issue with high incidence and mortality rates. MicroRNAs (miRNAs) play a crucial role in regulating gene expression and have been found to be dysregulated in BC. Understanding the role of miRNAs in BC development could lead to targeted therapies and improved patient management. Our study presents a thorough examination of the correlation between BC and miRNA research from 2008 to 2022. With the help of 3 powerful methods, including VOSviewer, Biblioshiny, and CiteSpace software, we analyzed the retrieved documents from "Core Collection databases online" on the Web of Science. In total, 798 articles were extracted from the Web of Science, and the number of published papers showed an upward trend from 2008 to 2019. The total number of citations was 21,233, of which the highest paper was a review article written by Chan Jiajia et al in 2018 with 752 citations. Based on the result of the coauthor analysis, Seki Naohiko was the most productive writer and China had the highest volume of published articles. Co-citation analysis was used to reveal the knowledge structure of the research field. In addition to the keywords "Bladder cancer" and "miRNA," "Proliferation," "Biomarkers," and "Apoptosis" were the high-frequency used keywords. Recently, increasingly researchers have paid more attention to the field about BC and miRNA around the worldwide. Through in-depth communication and close collaboration, the veil of miRNA in BC has gradually been unveiled. Bibliometric analysis helps to identify hotspots in research and areas for future investigation.

A bibliometric analysis and visualization of global food addiction over the last decade.

Food addiction is a chronic psychological disorder resulting from repeated consumption of highly palatable foods, leading to physical and mental harm. It involves individuals who struggle to control their intake of high-energy, high-fat, and high-sugar foods, often experiencing withdrawal reactions and intense cravings that trigger binge eating during stress. Recent research has focused on the impact of food addiction on physical health, nutrition, and mental well-being. This study aims to review and analyze current evidence on food addiction to advance research in China. A total of 941 articles on food addiction published between January 2013 and April 2023 were analyzed using the Web of Science Core Collection. CiteSpace software was utilized to identify research trends, collaborations among disciplines, authors, and institutions, as well as key topics and emerging keywords. The number of publications on food addiction has steadily increased over the past decade, with the United States leading in research output (393 articles). The University of Michigan and author Gearhardt AN were prominent contributors. Key research topics included obesity, eating disorders, addiction, and overeating. Emerging themes encompassed obesity psychology, food composition, brain function, and behavioral addiction. Global research on food addiction primarily focuses on understanding the psychological and neurological underpinnings, metabolic implications, addictive behaviors, and treatment modalities such as sleeve gastrectomy. Future research aims to develop personalized prevention and intervention strategies for food addiction.

Bibliometric analysis of orexin: A promising neuropeptide.

Orexin is an excitatory neuropeptide produced in the lateral hypothalamus, playing a role in various physiological functions in humans. There is a growing body of literature on orexins. This paper utilizes CiteSpace software to organize and analyze a significant number of articles on orexin, providing readers with an intuitive overview of research trends and emerging hot topics in this field. The electronic database, Web of Science Core Collection (WoSCC), was searched for publications related to orexins. Annual publications, countries/regions, institutions, authors and keywords were analyzed, and the results were visualized via CiteSpace software. A total of 5486 publications were included, with articles making up 85.30% and reviews 14.70%. The top 3 countries publishing the most papers on orexins were the United States (2057 papers), Japan (778), and China (556). The leading institutions included Research Libraries UK (278), Harvard University (250), and Stanford University (221). The most prolific authors in the field were Yves Dauvilliers (69), Abbas Haghparast (67), and Takeshi Sakurai (66). The most frequently used keywords were "neurons" (981), followed by "sleep" (824), "food intake" (612), "receptors" (547), and "neuropathology" (535). Recent research hotspots include melanin-concentrating hormone neurons, Alzheimer disease, gamma-aminobutyric acid neurons, oxidative stress, suvorexant, the orexin system, prevalence, and stress. Based on keyword clustering analysis, the top 5 research hotspots from 2003 to 2022 were: the effects of orexins on sleep and metabolism, potential pathways of orexin signaling, the relationship between orexin and immunity, new findings on depression and hypertension related to orexin, and possible targets for neurodegenerative diseases. Orexin, a neuropeptide linked to various physiological and pathological processes, plays a crucial role in sleep/wakefulness, reward mechanisms, stress responses, and neurodegenerative diseases. Its significant research value and potential medical applications are underscored by the rapid expansion of studies, particularly in the USA and Japan. However, the lack of collaboration among researchers highlights the need for enhanced academic exchange and cooperation to further advance the field of orexin research.

Worldwide research trends on bone metastases of lung cancer: a bibliometric analysis.

Lung cancer has the highest fatality rate among all malignancies worldwide. Within this disease, bone metastasis (BM) emerges as a particularly deleterious site of metastatic dissemination, marked by a dismal prognosis. The objective of this investigation is to shed light on the current international research efforts and the development trajectory on lung cancer BM through a bibliometric analysis (performance and visualization analysis). Data were obtained from the Web of Science Core Collection repository on lung cancer BM from 1 January 2012 to 1 January 2022. Subsequently, the collected data underwent scrutiny using the VOSviewer software to reveal patterns of co-authorship, co-citation, and keyword analysis, while the CiteSpace software facilitated the generation of keyword cluster maps and performed burst analyses. The study included 327 papers of 2,154 authors, 587 organizations, and 41 countries, and explored the cooperation between them and the relationships between citations. Over the past decade, published papers showed a steady growth trend. China had the highest production with 189 papers, and USA had the highest collaboration with other countries, with 43 total link strength. Lung Cancer exhibited the highest frequency of co-cited journals, with a co-citation time of 412 and an IF/JCR partition of 6.081/Q1 in 2021. The most frequently co-cited article, authored by Tsuya A and published in Lung Cancer in 2007, amassed 70 co-citations. High-frequency keywords were categorized into four clusters: pathogenesis, treatment and clinical manifestations, prognosis, and diagnosis. In recent years, there has been a significant increase in the strong citation burst strength of keywords such as "predictor," "skeletal-related events," "efficacy," "migration," "docetaxel," and "impact." Lung adenocarcinoma is the most common type of tumor. This bibliometric study provides a comprehensive analysis of lung cancer BM in the recent 10 years. The field of early diagnosis, pathogenesis, and new treatments is entering a phase of rapid development and remains valuable for future research.