For the standard HEU and various potential LEU and MEU cores of MNSR systems, a comparative neutronic study has been carried out using the cluster option in the WIMS-D/4 and RZ-model in the CITATION code. For the HEU core, the computed values of excess reactivity, control rod worth, shutdown margin and the value of equilibrium xenon worth are in good agreement with the corresponding values found in literature. The 235U enrichment required for the LEU UO2–Zr core found as 12.5% is in good agreement with the 12.6% found in literature. Compared with 1100g total uranium loading for the HEU core, the corresponding requirement for UO2, U3Si–Al, U3Si2–Al and U–9Mo–Al cores have been found as 10733.5, 6319, 5515 and 7549g respectively. For the HEU core, the computed 18.98mk value of the total worth of top Be shim plates is in good agreement with the corresponding experimental value of 18.5mk reported in FSAR. The corresponding computed values for LEU and MEU cores are 17.28mk for UO2–Zr fuel, 17.47mk for UO2–Al, 18.37mk for U3Si2–Al. Compared with 21.2year value for the HEU core, 30.6years cycle length for UO2–Zr LEU core has been found.