Twenty-one-week-old, worm-free, pen-reared lambs were infected with either 6000 O. circumcincta L3 per week, or 3000 H. contortus L3 per week, or both (9000 L3 per week). Egg counts were monitored throughout the experiment, and worm burdens and larval establishment rates of both worm species were estimated after 4, 7, 10 and 13 weeks of infection. After 10–13 weeks of infection with H. contortus only, establishment of O. circumcincta was lower than in previously uninfected controls, demonstrating that a high level of immunity to H. contortus affords some cross-protection against O. circumcincta. Total H. contortus worm burdens and egg counts (about 2000 worms and 3000 e.p.g., respectively) in sheep infected with both worm species were less than half those observed in sheep infected with H. contortus alone (about 5000 worms and 10,000 e.p.g., respectively). Cross-protection between the two species was observed, but was probably less important than the reduction in H. contortus establishment that was caused by O. circumcincta disrupting abomasal physiology.