The effects of the several factors on the changes in spectral degree of polarization P(ρ,-ρ,z) and spectral degree of coherence μ(ρ,-ρ,z), μ(ρ,0,z) for the partially coherent circular edge dislocation beam propagating in biological tissue have been studied. It is shown that both beam wavelength λ and dislocation number n have no effect on the initial values of the three, while the values of field points distance ρx and spatial self-correlation length σyy play a significant role. During the propagation, the curves of P(ρ,-ρ,z), μ(ρ,-ρ,z) and μ(ρ,0,z) with different beam parameters will undergo different fluctuation, eventually the former tends to be a certain value less than its initial one and the latter two tend to zero. The smaller ρx is, the higher the coherence of the beam is. The visible light is more suitable for biological tissue disease diagnosis compared to the far infrared and ultraviolet light. The beam with larger n will possess more richer optical distribution when propagating in biological tissues. The difference value between σyy and σxx will significantly influence the change range of P(ρ,-ρ,z), μ(ρ,-ρ,z) and μ(ρ,0,z).