A direct numerical simulation of hypersonic Shock wave and Turbulent Boundary Layer Interaction(STBLI) at Mach 6.0 on a sharp 7° half-angle circular cone/flare configuration at zero angle of attack is performed. The flare angle is 34° and the momentum thickness Reynolds number based on the incoming turbulent boundary layer on the sharp circular cone is Reθ = 2506. It is found that the mean flow is separated and the separation bubble occurring near the corner exhibits unsteadiness. The Reynolds analogy factor changes dramatically across the interaction, and varies between 1.06 and 1.27 in the downstream region, while the QP85 scaling factor has a nearly constant value of 0.5 across the interaction. The evolution of the reattached boundary layer is characterized in terms of the mean profiles, the Reynolds stress components, the anisotropy tensor and the turbulence kinetic energy. It is argued that the recovery is incomplete and the near-wall asymptotic behavior does not occur for the hypersonic interaction. In addition, mean skin friction decomposition in an axisymmetric turbulent boundary layer is carried out for the first time. Downstream of the interaction, the contributions of transverse curvature and body divergence are negligible, whereas the positive contribution associated with the turbulence kinetic energy production and the negative spatial-growth contribution are dominant. Based on scale decomposition, the positive contribution is further divided into terms with different spanwise length scales. The negative contribution is analyzed by comparing the convective term, the streamwise-heterogeneity term and the pressure gradient term.