Circadian Stimulus Research Articles

A novel circadian daylight metric for building design and evaluation

This paper extends the applicability of emerging frameworks for evaluating the non-visual effects of light through the development of a novel area-based daylighting metric addressing goals of human circadian stimulus and entrainment in buildings. Procedures using annual, climate-based daylight modeling of eye-level light exposures are developed to analyze and map indoor environments in regard to spatial and seasonal changes in the availability of a circadian-effective daylight stimulus. Because the biological effects of light exposure are not instantaneous, a novel approach is developed to assess the duration of an effective stimulus on a daily basis, as well as the frequency an effective stimulus is present over the course of a year. Results can be used to identify and visually examine building zones where long-term occupancy may lead to disruption of the circadian system in the absence of supplemental electrical lighting capable of effective circadian stimulus. The metric and visualization techniques are implemented in a parametric, simulation-based workflow utilizing publicly available software tools. The workflow can be used to assess and differentiate the performance of various daylighting strategies during the design phases of a project, or to examine existing spaces. The applicability of the workflow is demonstrated using two example models: a portable school classroom, and a generic open-plan commercial office floor plate.

Analysis of circadian stimulus allowed by daylighting in hospital rooms

Light is the major synchronizer of circadian rhythms to the 24-hour solar day. Compared to the visual system, the circadian system requires more light to be activated and is more sensitive to short-wavelength light. Without access to daylight, or electric lighting providing a comparable amount, spectrum, distribution, duration, and timing, human health and well-being may be compromised. This may be particularly true for those confined indoors, such as patients in hospitals and residents in care facilities. Architectural and design features, including window size, surface reflectances, and furniture placement, impact circadian stimulus levels. This paper details results of simulations used to determine the percentage of days that patients would receive a minimum level of circadian stimulation as a function of different window-to-façade ratios, surface reflectances, and latitudes.

Daylighting: Prediction of Circadian Effects of Different Spectral Filters

The study presented in this article aims to evaluate in which extent the interior colour surfaces affects human circadian stimulus. Experimental measurements in model rooms were evaluated by methods presented in studies by Rea et al. [1-3]. Even by high levels of daylight illuminances the colour of interior surfaces influences circadian stimulus, but this effect is not significant. Diminishing of circadian efficacy increases with application of dark blue-deficient colours of interior surfaces and by low intensity of daylight.

The influence of indoor lighting with low blue light dose on urine 6-sulphatoxymelatonin concentrations and sleep efficiency of healthy volunteers

Light, especially its blue component, is the main synchronizer of circadian rhythms. We investigated effects of suppressed blue band of the spectrum on melatonin production and sleep efficiency in 18 young volunteers. During control days, participants lived in their home environment, and next five days in a room lit only by daylight with windows equipped with a filter blocking the blue band of the light spectrum. Light intensity, circadian stimulus and light irradiance were monitored. No significant changes in the daily pattern and total urinary 6-sulphatoxymelatonin excretion were found between control and experimental conditions. Parameters of sleep efficiency measured by wrist actigraphy were not worsened, but neutral chronotypes exhibited shortened sleep duration under light-modified conditions. We conclude that young healthy people can compensate for negative effects of transitory-worsened lighting conditions on their daily rhythms, but chronotypes and other personal characteristics may modify biological responses and should be considered.

Colour of External Shading Obstacles and Circadian Stimulus of Indoor Daylighting

Colour of external shading obstacles can modify spectral composition of external interreflected component of indoor daylighting. This may play negative role for circadian efficacy of interior daylight. This article has two main purposes. First, the authors present conceptual framework of circadian photometry. Second, results of measurements of external shading obstacles colours influence on interior circadian stimulus in lighting climate in Bratislava are presented.

Indoor artificial lighting: Prediction of the circadian effects of different spectral power distributions

The study presented in this paper aims to evaluate if and how the environment affects the circadian impact of a light source by predicting circadian stimulus (CS) resulting from the exposure to different light scenes, using equations reported in studies by Rea et al. The main findings are: (1) Above 600 lx at eye level the increase of CS is little; (2) Between 50 lx and 200 lx at the eye level an increase of only 50 lx determines a significant increase of CS; (3) Light sources with correlated colour temperatures between 2900 K and 4200 K have similar impacts on the circadian system according to the calculation method used; (4) Even an almost neutral environment affects the circadian impact of a light source.

Regulation of alternative splicing by the circadian clock and food related cues

BackgroundThe circadian clock orchestrates daily rhythms in metabolism, physiology and behaviour that allow organisms to anticipate regular changes in their environment, increasing their adaptation. Such circadian phenotypes are underpinned by daily rhythms in gene expression. Little is known, however, about the contribution of post-transcriptional processes, particularly alternative splicing.ResultsUsing Affymetrix mouse exon-arrays, we identified exons with circadian alternative splicing in the liver. Validated circadian exons were regulated in a tissue-dependent manner and were present in genes with circadian transcript abundance. Furthermore, an analysis of circadian mutant Vipr2-/- mice revealed the existence of distinct physiological pathways controlling circadian alternative splicing and RNA binding protein expression, with contrasting dependence on Vipr2-mediated physiological signals. This view was corroborated by the analysis of the effect of fasting on circadian alternative splicing. Feeding is an important circadian stimulus, and we found that fasting both modulates hepatic circadian alternative splicing in an exon-dependent manner and changes the temporal relationship with transcript-level expression.ConclusionsThe circadian clock regulates alternative splicing in a manner that is both tissue-dependent and concurrent with circadian transcript abundance. This adds a novel temporal dimension to the regulation of mammalian alternative splicing. Moreover, our results demonstrate that circadian alternative splicing is regulated by the interaction between distinct physiological cues, and illustrates the capability of single genes to integrate circadian signals at different levels of regulation.

Conceptual design metrics for daylighting

Daylight is a key component of green building; however, no prevailing metric has emerged to help identify buildings that are well-daylit buildings. This paper proposes a ‘daylighting dashboard’; a visual representation of a design’s potential to meet eight design goals: average illuminance, coverage, diffuse daylight, daylight autonomy, circadian stimulus, glazing area, view and solar heat gain. This metric allows for informed decisions to be made early in the conceptual phase of design, and highlights aspects of design that may need further development, while there is still the opportunity to make modifications. These eight goals should be prioritized as appropriate for individual projects, rating systems or code requirements. This early indication of performance of conceptual design alternatives is likely to guide architects to better daylit buildings.

Rest-Activity and Light Exposure Patterns in the Home Setting: A Methodological Case Study

This methodological case study describes light exposure and rest-activity patterns in an older adult with dementia and his caregiver spouse. Two devices were used to measure rest-activity and light exposure data: a wrist-worn actigraph with a light sensor to record full spectrum light exposure data and an eye-level wavelength-sensitive light meter (Daysimeter). The wife wore both devices simultaneously; the husband wore only the actigraph. There were minimal feasibility issues in using the devices in the home setting. The wife's light exposure was considerably better than her husband's, but she spent little time in bright lighting. Her circadian stimulus (CS) and rest-activity values suggest a high level of circadian disruption. This case study provides beginning support for the use of the Daysimeter in the home setting while also highlighting unrecognized circadian disturbances and very low light levels in an older couple's home.

Circadian light.

The present paper reflects a work in progress toward a definition of circadian light, one that should be informed by the thoughtful, century-old evolution of our present definition of light as a stimulus for the human visual system. This work in progress is based upon the functional relationship between optical radiation and its effects on nocturnal melatonin suppression, in large part because the basic data are available in the literature. Discussed here are the fundamental differences between responses by the visual and circadian systems to optical radiation. Brief reviews of photometry, colorimetry, and brightness perception are presented as a foundation for the discussion of circadian light. Finally, circadian light (CLA) and circadian stimulus (CS) calculation procedures based on a published mathematical model of human circadian phototransduction are presented with an example.

Preliminary Method for Prospective Analysis of the Circadian Efficacy of (Day)Light with Applications to Healthcare Architecture

Recent studies have attempted to link environmental cues, such as lighting, with human performance and health, and initial findings seem to indicate a positive correlation between the two. Light is the major environmental time cue that resets the human circadian pacemaker, an endogenous clock in the hypothalamus that controls the timing of many 24-hour rhythms in physiology and behavior. Insufficient or inappropriate light exposure can disrupt normal circadian rhythms which may result in adverse consequences for human performance, health and safety.This paper addresses the problem of prospective analysis of building architecture for circadian stimulus potential based on the state of the art in photobiology. Three variables were considered in this analysis: lighting intensity, timing, and spectrum. Intensity is a standard design tool frequently used in illuminating engineering. Timing and spectrum are not commonplace considerations, so the analysis that follows proposes tools to quantitatively address these additional requirements.Outcomes of photobiology research were used in this paper to define threshold values for illumination in terms of spectrum, intensity, and timing of light at the human eye, and were translated into goals for simulation – and ultimately for building design. In particular, the climate-based Daylight Autonomy (DA) metric was chosen to simulate the probabilistic and temporal potential of daylight for human health needs.The developed method was applied to study the impact of key architectural decisions on achieving prescribed stimulus of the circadian system in a hospital patient room design; studied variables included orientation, window size, and glazing material. A healthcare setting was specifically chosen with the intent of follow-on research to validate our findings with actual patient outcome data.

Of Mice and Women: Light as a Circadian Stimulus in Breast Cancer Research

Nocturnal rodents are frequently used as models in human breast cancer research, but these species have very different visual and circadian systems and, therefore, very different responses to optical radiation or, informally, light. Because of the impact of light on the circadian system and because recent evidence suggests that cancer risk might be related to circadian disruption, it is becoming increasingly clear that optical radiation must be properly characterized for both nocturnal rodents and diurnal humans to make significant progress in unraveling links between circadian disruption and breast cancer. In this paper, we propose a quantitative framework for comparing radiometric and photometric quantities in human and rodent studies. We reviewed published research on light as a circadian stimulus for humans and rodents. Both suppression of nocturnal melatonin and phase shifting were examined as outcome measures for the circadian system. The data were used to develop quantitative comparisons regarding the absolute and spectral sensitivity for the circadian systems of humans and nocturnal rodents. Two models of circadian phototransduction, for mouse and humans, have been published providing spectral sensitivities for these two species. Despite some methodological variations among the studies reviewed, the circadian systems of nocturnal rodents are approximately 10,000 times more sensitive to optical radiation than that of humans. Circadian effectiveness of different sources for both humans and nocturnal rodents are offered together with a scale relating their absolute sensitivities. Instruments calibrated in terms of conventional photometric units (e.g., lux) will not accurately characterize the circadian stimulus for either humans or rodents.

Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y

Neuropeptide Y (NPY) is a potent orexigenic peptide that is implicated in the feeding response to a variety of stimuli. The current studies employed mice lacking NPY ( Npy−/−) and their wild-type ( Npy+/+) littermates to investigate the role of this peptide in the feeding response to circadian and palatability cues. To investigate the response to a circadian stimulus, we assessed food intake during the 4-h period following dark onset, a time of day characterized by maximal rates of food consumption. Compared to Npy+/+ controls, intake of Npy− /− mice was reduced by 33% during this period (0.6 ± 0.1 g versus 0.9 ± 0.1 g; p ≤ 0.05). In contrast, intake did not differ between genotypes when measured over a 24-h period (3.7 ± 0.2 g versus 3.5 ± 0.3 g; p = ns). Furthermore, reduced dark cycle 4 h food intake in Npy− /− mice was not evident after a 24-h fast (1.4 ± 0.1 g for both genotypes; p = ns), despite a pronounced delay in the initiation of feeding (636 ± 133 s versus 162 ± 29 s; p ≤ 0.05). To investigate the role of NPY in the feeding response to palatability cues, mice were presented with a highly palatable diet (HP) for 1 h each day (in addition to having ad libitum access to chow) for 18 days. Npy+/+ mice rapidly increased daily HP intake such that by the end of the first week, they derived a substantial fraction of daily energy from this source (41 ± 3%). By comparison, HP intake was markedly reduced in Npy−/− mice during the first week (24 ± 7% of daily energy intake, p ≤ 0.05 versus Npy+/+), although it eventually increased (by Day 9) to values comparable to those of Npy+/+ controls. These experiments suggest that NPY contributes to the mechanism whereby food intake increases in response to circadian and palatability cues and that mechanisms driving food intake in response to these stimuli differ from those activated by energy restriction.