“Highlights” calls attention to exciting advances in developmental biology that have recently been reported in Developmental Dynamics. Development is a broad field encompassing many important areas. To reflect this fact, the section spotlights significant discoveries that occur across the entire spectrum of developmental events and problems: from new experimental approaches, to novel interpretations of results, to noteworthy findings utilizing different developmental organisms. Deceptively simple (Wnt Won the War: Antagonistic Role of Wnt Over Shh Controls Dorsoventral Patterning of the Vertebrate Neural Tube by Fausto Ulloa and Elisa Martí, Dev Dyn 239:69–76) Dorsoventral (D/V) patterning in the neural tube (nt) appears to operate on principles of straightforward design. In addition to other molecules, opposing signals from ventrally localized Sonic hedgehog (Shh) and dorsally localized Wnts combine to produce a readout of cell types localized to specific points along the D/V axis. Although mechanisms of patterning by Shh are relatively well understood, those of Wnts are not. In this review, Ulloa and Marti argue that one of the main functions of Wnts in this context is to promote dorsal identities while inhibiting ventral ones. They present evidence that at the dorsal nt, Wnt and/or its downstream effector β-catenin directly activates expression of Gli3, the repressor form of which inhibits expression of Shh target genes. Wnt/β-cat also appears to specify fates by mechanisms independent of the Shh/Gli pathway. Whether in the latter case Wnt/β-cat affects patterning directly, or by means of cross-talk with other molecular pathways, remains to be determined. The data presented reinforce the notion that a good design looks simple but masks the complexity beneath it. Diffusing the destruction complex (Xenopus Axin-Related Protein: A Link Between Its Centrosomal Localization and Function in the Wnt/β-Catenin Pathway by Evguenia M. Alexandrova and Sergei Y. Sokol, Dev Dyn 239:261–270) Wnt pathway's “destruction complex” is merciless. In the absence of Wnt ligand, the complex marks β-catenin—the transcriptional activator of Wnt targets—for destruction. How does the cell keep this killing machine at bay? Alexandrova and Sokol find that a destruction complex component, Xenopus axin-related protein (XARP) localizes to centrosomes and basal bodies—modified centrosomes that initiate and maintain cilia growth. Furthermore, overexpressed XARP lacking most of its DIX domain, or adjacent conserved, charged residues, leaves its centrosomal post and becomes distributed throughout the cytoplasm. These mutants also display reduced binding to Dishevelled (Dsh), a protein that promotes β-catenin stability and thus activation of Wnt targets. Accordingly, Wnt reporter assays show that XARP DIX domain mutants have increased inhibitory activity. The results illuminate the possibility that association with centrosomes may attenuate the destruction complex. This is an intriguing finding particularly in light of other work suggesting that cilia, the assembly of which depends on centrosomal centrioles, are important for normal Wnt activity. Future studies will gauge the relative contributions of subcellular localization and Dsh binding in keeping destruction complex activity in check. Demistifying iguana (The Iguana/DZIP1 Protein Is a Novel Component of the Ciliogenic Pathway Essential for Axonemal Biogenesis by Shang Yew Tay, Xianwen Yu, Kangli Noel Wong, Pallavi Panse, Chee Peng Ng, and Sudipto Roy, Dev Dyn 239:527–534) The iguana (igu) mystery first crept out from the shadows 6 years ago. Zebrafish lacking Dzip1, the zinc finger protein encoded by igu, display altered Sonic hedgehog (Shh) signaling. Yet it remained a puzzle as to how igu fit into the Shh pathway. Inspired by work demonstrating that immotile, primary cilia are a repository for Shh pathway components, Tay and colleagues postulated that igu might have a primary function in ciliogenesis. Confirming their hypothesis, they present here that igu mutants lack primary cilia. Furthermore, in igu cells that normally bear primary cilia, basal bodies—modified centrosomes from which cilia are derived—are present in normal numbers and are correctly localized. However, characteristic ciliary pits and axonemes—ciliary inner cytoskeletal structures—are absent. Agreeing with a role in cilia growth, stable transgenic zebrafish lines bearing gfp-igu display puncta near or colocalized with basal bodies. Of interest phenotypes in igu motile cilia, reduced cilia numbers and/or length, are less penetrant. These effects could be due to functional redundancy of igu/dzip1 with a paralogous gene, dzip1-like. With the original iguana mystery solved, a new one rears its head. How does igu/dzip1 regulate ciliary pit formation and axoneme growth?