Objectives: The potential association between e-cigarette use and cigarette smoking persists as an importantpublic health issue. Strictly adhering to AMSTAR 2 and PRISMA guidelines, our evidence synthesis examinedthe association between e-cigarette use among non-tobacco users and the intention to smoke cigarettes.Methods: We searched 3 databases from January 1, 2007 to April 26, 2023 and screened search resultsaccording to the PICOS review method. Results: We synthesized 20 demographically adjusted studieson smoking intention, including related outcome measures of willingness/openness/curiosity to smokecigarettes and susceptibility to smoke cigarettes. All studies suggested a significant association betweene-cigarette use and intention to smoke according to measures of experimental e-cigarette use (i.e., ever orcurrent use, and not established and/or regular use). Conclusions: Studies defining e-cigarette use accordingto measures of established and/or regular use, and that adequately controlled for specific confoundingvariables representing common liabilities between e-cigarette use and cigarette smoking are limited in theevidence base. Thus, currently there is limited evidence to support an association between e-cigarette useand the intention to smoke cigarettes. Future research should apply measures of regular and/or establishede-cigarette use that adequately account for confounding variables that consider common liabilities betweene-cigarette use and cigarette smoking. Doing so would enable the findings to support robust determinationsregarding any potential association between e-cigarette use and the intention to smoke cigarettes.
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