Aim: The aim of the study was to assess discoloration potential of four different intracanal medicaments. Materials and Methods: Thirty single-rooted extracted bovine incisors were sectioned to a standardized root length, accessed, instrumented, and placed with temporary filling and cotton pellet. The specimens were divided into five groups (n = 6): Control group with no intracanal medicament and four groups with the following medicaments, i.e., calcium hydroxide (Ca(OH) 2 ), calcium hydroxide with chlorhexidine (Ca(OH)2 with CHX), triple antibiotic paste (TAP), and silver diamine fluoride (SDF), respectively. Calorimetric evaluation, according to CIE L*a*b* system, was performed at pretreatment, on day 1, 7, 14, and 21. Data were analyzed using One-Way ANOVA and Repeated ANOVA. P Results: The greatest color change (ΔE*) was observed at day 21 in TAP group (P Conclusions: Ca(OH)2 and Ca(OH)2 with the CHX groups showed the smallest coronal discoloration during the experimental time, whereas TAP and SDF groups showed the highest coronal discoloration.