Chronic Suppurative Sinusitis Research Articles

Balloon sinuplasty as a present-day minimum invasion surgery method of treatment of the patients with chronic suppurative maxillary sinusitis

The article presents the literature and the authors’ own data on diagnostics of chronic suppurative maxillary sinusitis. The authors describe in details a method of balloon sinuplasty in the treatment of chronic maxillary sinusitis and present the criteria of selection of patients, short-term and long-term treatment results.

Analysis of bacterial distribution and drug sensitivity of chronic suppurative sinusitis

Objective To investigate the bacterial distribution and drug sensitivity characteristics of chronic suppurative sinusitis. Methods Nasal secretions of 89 cases of chronic suppurative sinusitis patients before operation were collected in this study, and nasal secretions were culture in medium.Disk diffusion method(Kirby-Bauer,K-B)was used for drug sensitivity test.Sensitivity of bacteria strain to cefazolin, ceftazidime, cefepime, imipenem, meropenem, vancomycin, cefoperazonesulbactam, ciprofloxacin and other antibiotics were analyzed. Results After the submission of purulent secretion specimens of nasal meatus in 89 cases chronic suppurative sinusitis patients with sticky, we found that 80 of the patients were detected bacteria. The positive rate was 89.89%(80/89).80 patients were detected in 82 strains of bacteria,a total of 15 species,of which 1 cases of nasal meatus sticky purulent secretion specimens there were 2 strains of bacteria.In 15 kinds of staphylococcus aureus were detected bacteria, staphylococcus aureus, escherichia coli, pseudomonas, enterobacter aerogenes,5 kinds of bacteria occupy the top 5,respectively,accounted for 21.95%,18.29%,14.63%,13.41%,10.98%.Drug sensitivity test of staphylococcus aureus showed that all of the staphylococcus aureus was sensitive to vancomycin, the sensitivity was 100%; the sensitivity of cefazolin, ceftazidime, cefepime, imipenem, meropenem, cefoperazone sulbactam, ciprofloxacin and other antibiotics were 0.00%.All the staphylococcus epidermidis were sensitive to imipenem, meropenem, vancomycin, cefoperazone sulbactam, the sensitivity was 100.00%;followed by cefazolin,the sensitivity was 86.67%,and to ceftazidime, cefepime, ciprofloxacin sensitive, were all below 30.00%. Escherichia coli,pseudomonas aeruginosa and enterobacter aerogenes and other gram negative bacteria were sensitive to imipenem,meropenem,the sensitivity was 100.00%. Conclusion The bacterial infection in patients with chronic suppurative sinusitis pathogens, including staphylococcus epidermidis, staphylococcus aureus, escherichia coli, pseudomonas, enterobacter aerogenes, bacterial culture positive to vancomycin, imipenem, meropenem, cefoperazone Shubatan, cefazolin and antimicrobial susceptibility, and so on antimicrobial treatment but should closely monitor the antimicrobial spectrum of change, in order to adjust the medication. Key words: Suppurative sinusitis; Bacteria; Antibiotics; Sensitivity

Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.

A growing number of DNA polymerases have been identified, although their physiological function and relation to human disease remain mostly unknown. DNA polymerase lambda (Pol lambda; also known as Pol beta2) has recently been identified as a member of the X family of DNA polymerases and shares 32% amino acid sequence identity with DNA Pol beta within the polymerase domain. With the use of homologous recombination, we generated Pol lambda(-/-) mice. Pol lambda(-/-) mice develop hydrocephalus with marked dilation of the lateral ventricles and exhibit a high rate of mortality after birth, although embryonic development appears normal. Pol lambda(-/-) mice also show situs inversus totalis and chronic suppurative sinusitis. The surviving male, but not female, Pol lambda(-/-) mice are sterile as a result of spermatozoal immobility. Microinjection of sperm from male Pol lambda(-/-) mice into oocytes gives rise to normal offspring, suggesting that the meiotic process is not impaired. Ultrastructural analysis reveals that inner dynein arms of cilia from both the ependymal cell layer and respiratory epithelium are defective, which may underlie the pathogenesis of hydrocephalus, situs inversus totalis, chronic sinusitis, and male infertility. Sensitivity of Pol lambda(-/-) cells to various kinds of DNA damage is indistinguishable from that of Pol lambda(+/+) cells. Collectively, Pol lambda(-/-) mice may provide a useful model for clarifying the pathogenesis of immotile cilia syndrome.

Preferential infiltration by activated eosinophils in allergic sinusitis

Although Type I allergy is a trigger for provoking chronic inflammation, whether allergic sinusitis (AS) can be distinguished from sinusitis due to chronic infection is still debated. This study was performed to characterize inflammatory cells in AS and to determine whether patients with AS differ from patients with chronic suppurative sinusitis (CSS). 5 patients with AS and 10 patients with CSS were investigated. Cellular infiltration was studied using immunohistochemistry with monoclonal antibodies against CD3, CD4, CD8, CD25, major basic protein (BMK13), eosinophil cationic protein (EG2), neutrophil elastase, and tryptase. There were no differences in CD3+, CD4+, CD25+, and tryptase+ cells between the groups. Whereas the total number of eosinophils (BMK13+) also did not significantly differ, the number of activated eosinophils (EG2+) was significantly higher (P<0.05) in patients with AS. Furthermore, a statistically significant increase in the percentage of activated eosinophils to total eosinophils (P<0.05) was observed in patients with AS. In contrast, the number of neutrophil elastase+ cells was significantly higher (P<0.05) in patients with CSS. These results suggest that patients with AS can be distinguished immunohistochemically from patients with CSS, with AS being distinguished by activated eosinophil infiltration.

Infections of the Maxillary Sinus

SUMMARY Most sinus disease is the result of obstruction of the natural ostium, failure of the mucociliary transport system, or an overproduction or change in viscosity of sinus secretions with eventual contamination and bacterial colonization. Acute maxillary sinusitis demands urgent medical treatment. Surgical treatment should be avoided when possible because of the high incidence of complications. Chronic maxillary sinusitis is treated with medications, drainage and irrigation, and surgery to eliminate pathologic tissue and re-establish normal sinus function. Diagnostic procedures for sinus infections include a thorough medical history, a review of the signs and symptoms, radiographs, and sinus aspiration. Other illnesses that may contribute to the patient's susceptibility to sinusitis should be considered, particularly when the condition is chronic and recurrent. The most common organisms isolated from acute sinusitis are Haemophilus influenzae and Branhamella (Moraxella) catarrhalis, both of which can be beta-lactamase producers. This affects the choice of antibiotics for treatment of the disease. Chronic suppurative sinusitis is usually a mixed infection with a greater predominance of anaerobes than is found in acute sinusitis. The oral and maxillofacial surgeon should be alert to any of the potential complications of sinus infection, in particular in the older or physically debilitated patient. The need for consultation and joint treatment efforts with other specialists, including the otolaryngologist, neurosurgeon, allergist, and infectious disease physician, when complications are suspected is obvious. As is true with virtually every condition treated in the practice of oral and maxillofacial surgery, a knowledge of the disease process, timely diagnosis, and effective and aggressive medical and surgical treatment when indicated also will generally bring about a resolution of maxillary sinusitis. In this manner, complications are avoided, and the patient is returned to a healthy, physiologically stable condition.

鼻性硬膜下膿瘍の一症例

A case of subdural abscess originating from chronic suppurative sinusitis of the right side is reported. The patient was a female aged 21 years, who was hospitalized after appearance of right frontal headache and fever of low grade for 7 days. Headache and high fever continued and her consciousness became drowsy 10 days after admission. X-ray and CT examination revealed rhinogenic subdural abscess. Surgical treatment of the right frontal and ethomoid sinuses by Killian's method was carried out. A drainage was placed through a burr hole and craniotomy was carried out.She completely recovered after 8 weeks since t he first day of admission.The X-ray and CT examination is considered to be most helpful for the diagnosis of subdural abscess.

It is really sinusitis?

To answer the question Is it really sinusitis? one must take a careful history, look into the nose, palpate the infected sinuses, and obtain roentgenograms. A history of pain, mucopurulent discharge, nasal obstruction, and systemic involvement should be present for a diagnosis of acute suppurative sinusitis. Physical findings and the presence of a predisposing factor help in the diagnosis, and roentgenographically demonstrated changes of the involved sinus can substantiate it. Acute suppurative sinusitis necessitates antibiotic therapy, which should be continued for seven days after the primary symptoms are relieved in order to avoid recurrence or development of subacute or chronic suppurative sinusitis. Chronic sinusitis requires surgical intervention to remove the diseased mucosa, and the sinuses must be ventilated (oxygenated) for resolution to occur.

Studies on the obliterative operation with preserved homogenous bone and deproteinized heterogenous bone for chronic suppurative sinusitis

Studies on the obliterative operation with preserved homogenous bone and deproteinized heterogenous bone for chronic suppurative sinusitis

HISTOPATHOLOGICAL STUDY OF BONY CHANGES IN CHRONIC SUPPURATIVE SINUSITIS

Author made an observation of bone pathology in the patients with chronic suppurative sinusitis. Results of histopathological observation were as follows: The pathological changes of the bone in maxillary and ethmoid sinuses were found in 25% of the cases, though the changes were not remarkable. In 75% of the cases, changes in the bone were within normal limits. In addition, changes in mucous membrane, laboratory tests and many clinical problems were discussed.

TREATMENT OF CHRONIC SINUSITIS WITH PENICILLIN

THIS REPORT is a record of the results obtained in 11 patients with chronic sinusitis treated with penicillin administered locally and systemically, alone and in combination. A large number of patients with acute, subacute and chronic sinus infections were treated successfully by the usual procedures, but these few did not respond. Even in so small a group there has been considerable variation in treatment with penicillin. An unusual opportunity was presented to observe them over a comparatively long time, since treatment was continued until maximum benefit was obtained. Several authors1have reported favorable results with locally administered penicillin in the treatment of acute, subacute and chronic sinusitis. Satisfactory results have been obtained with penicillin administered systemically or locally combined with surgical procedure.2Hauser and Work2ereported cures of chronic suppurative sinusitis of relatively short duration by intramuscular injection of penicillin alone; however, in long-standing sinus disease penicillin alone appeared to

ROLE OF PENICILLIN IN THE MANAGEMENT OF ACUTE AND CHRONIC FRONTAL SINUSITIS

AS EARLY as July 1943, at Halloran General Hospital, Champ Lyons and his co-workers had definitely shown the marked bacteriostatic effect of penicillin in suppurating wounds infected with streptococci and staphylococci. Because of the good results being obtained by them, it was decided to use this antibiotic substance in the treatment of suppurative frontal sinusitis. The cases to be presented were selected because they represent the ones that were the more serious from a prognostic point of view. The degree of pathologic involvement presented varied from acute, nonsuppurative, uncomplicated to chronic suppurative sinusitis with intracranial complications. Because certain strains of gram-positive micro-organisms were known to be resistant to penicillin, great effort was made to select those cases in which bacterial studies of penicillin sensitivity were possible or in which clinical experience, from a bacteriologic standpoint, gave reasonable assurance of excellent results. Tests of sensitivity were done in all cases in

Penicillin therapy in chronic suppurative sinusitis. A report of 22 cases

The LaryngoscopeVolume 57, Issue 7 p. 460-478 Article Penicillin therapy in chronic suppurative sinusitis. A report of 22 cases† Harold Boyd M.D., Harold Boyd M.D. Los Angeles 14, Calif.Search for more papers by this author Harold Boyd M.D., Harold Boyd M.D. Los Angeles 14, Calif.Search for more papers by this author First published: July 1947 https://doi.org/10.1288/00005537-194707000-00003Citations: 2 † Presented as Candidate's Thesis to American Laryngological, Rhinological and Otological Society, Inc., 1947. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume57, Issue7July 1947Pages 460-478 RelatedInformation

FOREIGN BODY INVOLVING THE MAXILLARY ANTRUM

A CASE of foreign body involving the antrum is presented because it illustrates that the persistence of a foreign body in a nasal accessory sinus always leads to chronic suppurative sinusitis and this, in turn, to suppuration elsewhere. Schroder¹stated that foreign bodies may enter through the nose or through openings in the antral walls caused by injuries or by dental trauma. The latter may be voluntary, surgical or accidental in extraction of a tooth or treatment of dental roots. He stated further that the behavior of these foreign bodies in the sinus differs. Healing like that observed where foreign bodies are lodged in muscle and connective tissue does not occur. The most probable defense reaction would consist in an effort to expel the foreign thing. The literature contains reports of cases in which small foreign bodies have been expelled through the maxillary ostium, with more or less marked inflammatory

Survey of bronchial asthma in soldiers: Bronchoscopic findings and incidence of respiratory infection

1. 1. A survey of 250 cases of perennial bronchial asthma in soldiers, in whom routine diagnostic studies were supplemented by bronchoscopy, has been presented. 2. 2. Of those cases, 81.4 per cent were medical casualties evacuated from overseas, 84 per cent were under 35 years of age, and 43.8 per cent had asthma of less than five years' duration. 3. 3. Fifty per cent of the patients had chronic suppurative sinusitis. 4. 4. Bronchoscopy revealed bronchial abnormalities in 89.6 per cent of the series. These were differentiated as (1) chronic suppurative bronchitis in 49.2 per cent; (2) chronic nonsuppurative bronchitis in 38.8 per cent; and (3) allergic bronchitis in 1.6 per cent. 5. 5. Chronic bronchial infection was noted in a significant number of young individuals with asthma of relatively short duration. 6. 6. In this series, chronic suppurative infection of the respiratory tract was found in 73.2 per cent of all patients. 7. 7. The significance of this observed incidence of chronic respiratory infection in asthma has been briefly discussed.

Caldwell-Luc Operation for Chronic Suppurative Maxillary Sinusitis of Traumatic Origin

Caldwell-Luc Operation for Chronic Suppurative Maxillary Sinusitis of Traumatic Origin

RHINITIS CASEOSA

Rhinitis caseosa has been defined as a rare type of unilateral nasal disease characterized by the accumulation in the nose and paranasal sinuses of an extremely offensive, cheeselike mass, by the presence of a seropurulent nasal discharge and other manifestations of chronic suppurative sinusitis and, lastly, by intranasal, and frequently external, deformities which result from pressure exerted by the caseous mass. <h3>REPORT OF CASE</h3> R. P., a 13 year old farmer's son from near Ionia, Mich., was admitted to the University Hospital onNov. 28, 1939 with the complaint of complete nasal obstruction and copious foul nasal discharge. He had never been susceptible to colds and had had no nasal symptoms prior to the fall of 1938. At that time he had an acute infection of the upper respiratory tract, which was followed by a copious mucopurulent nasal discharge. The patient stated that he had used three handkerchiefs a day

FUNGOUS INFECTIONS OF THE SINUSES

Fungi are frequent saprophytic invaders of the human body. Occasionally they become parasitic and produce definite pathologic processes. Almost every organ in the body has been invaded by pathogenic fungi, and in this respect the accessory nasal sinuses are no exception. Although the condition is rare, enough cases of mycotic infection of the nasal sinuses have been reported to establish it as a definite clinical entity. The earliest cases on record are those of Hernu¹and Plaignaud,²who in 1791 made the diagnosis of fungous infection of the maxillary sinus from the gross appearance of the disease. Zarniko³in 1891 reported the first case of aspergillosis of the sinuses. The chief symptoms were those of chronic suppurative sinusitis with occlusion of the nose. The organism was determined by microscopic examination to be Aspergillus fumigatus. In 1893 Mackenzie⁴described a case of aspergillus invasion of the maxillary sinus. The symptoms were

Use of undenatured bacterial antigen in chronic suppurative sinusitis

Use of undenatured bacterial antigen in chronic suppurative sinusitis

RHINITIS CASEOSA: ANALYSIS OF THE LITERATURE AND REPORT OF A CASE

Rhinitis caseosa is a rare type of unilateral nasal disease characterized by the accumulation in the nose and sinuses of an extremely offensive, cheeselike mass, by the presence of a seropurulent discharge and other manifestations of chronic suppurative sinusitis and last by intranasal and frequently by extranasal deformity. The term rhinitis caseosa was conceived by Duplay in 1874. It was his opinion, based on experience with two cases and on a paper by Maisonneuve in 1855, that facial erysipelas precedes the development of rhinitis caseosa. The erysipelas involves the nasal mucosa by extension, whence epithelial exfoliations and the retention of the exfoliated débris result in the formation of the characteristic foul, cheeselike mass, which Duplay considered to be "analogous to the contents of certain sebaceous cysts." Subsequent authors found no quarrel with Duplay's classic description of the endonasal picture and postoperative course of this disease,

CHRONIC SUPPURATIVE SINUSITIS: A POINT OF VIEW AS TO TREATMENT

So much has been written in recent years about the necessity of radical external operations and the meticulous removal of every vestige of lining mucous membrane in chronic suppurative pansinusitis that one wonders whether the surgical axiom of adapting an operation to the pathologic condition encountered rather than adapting the patient to a certain operative technic still holds true. The technical approach to the surgical problem involved in the successful management of chronic suppurative sinusitis may in a large measure be dependent on the capability of the surgeon. It would be entirely contrary to my clinical and surgical experience to concede that it is necessary to remove every vestige of lining mucous membrane in every case of chronic suppuration of a paranasal sinus. It is frequently claimed that the membranes should be removed because bacteria are found in specimens of membrane that are examined. The validity of this