Background: A quasi experimental study to evaluate the effectiveness of guided imagery technique inreduction of stress level among chronic renal failure patients. The aim of the study wasto determine thestress level among patients with chronic renal failure in experimental group after introduction of guidedimagery. Methods and Material: A true experimental two-group pre-test - post-test design was used for thepresent study. The sample consisted of 100 chronic renal failure patients undergoing dialysis were randomlyassigned to experimental group and control group (N=50+50=100). Data was analysed using paired andunpaired‘t’ test, chi-square test, Karl Pearson correlation co-efficiency, and Spearman’s correlation coefficiency. Results: In experimental Group 62% of the samples had moderate level of stress, 20% of thesamples had severe level of stress and 18% of the samples had mild level of stress with mean and SD of64.02, 5.88. There was a significant reduction in the mean post test stress score of experimental groupcompared to mean pre test stress score of experimental group at 0.05 level of significance. (t49 = 6.526, P< 0.05). The results showed that chronic renal failure patients had significant level of stress related to theirillness and guided imagery is an effective intervention for reduction of stress. Conclusion: Guided imageryis a simple non-invasive, cost effective, method that can be used for reduction of stress without any adverseeffects on the patients. Patients themselves can practice their own imagery without any assistance.