Chronic Relapsing Inflammatory Optic Neuropathy Research Articles

Recurrent subacute visual loss presenting in a 52-year-old Caucasian woman with chronic relapsing inflammatory optic neuropathy: a case report

IntroductionChronic relapsing inflammatory optic neuropathy is a recently described form of recurrent isolated subacute optic neuropathy. The condition is highly responsive to systemic steroid treatment and prone to relapse on steroid withdrawal. A complete work up for demyelination, autoimmune disease and sarcoidosis must be made before considering chronic relapsing inflammatory optic neuropathy.Case presentationWe describe the case of a 52-year-old Caucasian woman who presented with isolated subacute optic neuropathy. There was no evidence of demyelination, autoimmunity or sarcoidosis. There was an abrupt and prompt response to systemic corticosteroids and a relapse of the condition on steroid withdrawal.ConclusionsChronic relapsing inflammatory optic neuropathy requires careful consideration and differentiation from demyelinating optic neuritis and ischemic optic neuropathy since the treatment is different and the outcome without treatment is likely to be poor. The importance of identifying these patients has considerable clinical implications as the condition is highly responsive to steroids.

A case of chronic relapsing inflammatory optic neuropathy (crion)

AbstractPurpose The chronic relapsing inflammatory optic neuropathy (CRION) is a recurrent optic neuropathy not associated with any demyelinating or systemic desease, characterized by the need for prolonged immunosuppressive therapy to prevent relapse.Methods We report the case of a 32 year old man who presented three episodes of optic neuritis in the left eye over a period of 8 months. Each episode remitted quickly with intravenous steroids and resorted after gradual withdrawal thereof. The initial visual acuity in left eye was counting fingers, had relative afferent pupillary defect and diffuse edema of the optic nerve. All systemic examinations were normal (analytics, and serology tests, imaging studies, lupus anticoagulant, ECA and autoimmunity tests).Results After CRION suspected, corticosteroid treatment was decided at a dose of 1mg/kg/day maintained in decreasing doses associated with azathioprine, and response to treatment was favorable, with no new episodes. Actually, visual acuity is 7/10 , there are palidness optic disc and inferior visual field lost in perimetry due to optic neuritis.Conclusion CRION is a recurrent optic neuritis, corticoid dependent, not associated with any neurological deficit or autoimmune disease. Severe visual loss, associated with persistence of pain after onset of visual loss and frequent recurrences should make us suspect this entity.

Chronic relapsing inflammatory optic neuropathy

Chronic relapsing inflammatory optic neuropathy (CRION) is a recently described recurrent optic neuropathy which is steroid responsive. Several features distinguish this entity from optic neuritis associated with demyelinating disorders and connective tissue diseases. The severe degree of visual loss, persistence of pain after onset of visual loss, and recurrent episodes are unique to this disorder. We describe here a patient who presented with recurrent episodes of painful visual loss, followed by resolution of deficits, over a period of ten years. He was diagnosed as isolated optic neuritis conforming to features of CRION.

Immunoglobulins as steroid sparing agents in chronic relapsing inflammatory optic neuropathy

Immunoglobulins as steroid sparing agents in chronic relapsing inflammatory optic neuropathy

51-year-old female with steroid-responsive optic neuropathy: a new case of chronic relapsing inflammatory optic neuropathy (CRION)

51-year-old female with steroid-responsive optic neuropathy: a new case of chronic relapsing inflammatory optic neuropathy (CRION)

The use of infliximab in ocular inflammation

Aims:Experience with anti-tumour necrosis factor α medications in ophthalmology has been mainly in the treatment of resistant uveitis and scleritis. There have been a few case reports and one case...