Purpose of the study. analysis of the prevalence of the main risk factors for the development of chronic NCDs in the unorganized population of the Altai Territory aged 25–64 years.Materials and methods. The study involved 1,103 people aged 25–64 years, selected by random sampling from the population of the Altai Territory. The survey was conducted using a standard questionnaire. During the study, the blood pressure level, height, and weight of respondents were measured.Results. The study involved 1103 people, of whom 33.4 % were men (n = 368), women – 66.6 % (n = 735). Smoking was registered in 21.5 % (n = 234), among men – 45.7 % (n = 166), among women – 9.4 % (n = 68). IBP of salt was detected in 58.9 % (n = 650), among men – 63.6 % (n = 234), among women – 56.6 % (n = 416). Consumption of less than 5 servings of fruits and/or vegetables on average per day was noted in 55.7 % (n = 597), among men – 67.6 % (n = 244), among women – 49.6 % (n = 353). NFA occurs in 19.9% (n = 218), among men – 19.4 % (n = 71), women – 20.1 % (n = 47). Obesity occurs in 34.9 (n = 349), among men – 22.3 % (n = 73), women – 41% (n = 276). High blood pressure among all respondents was 50.3 %; in men this risk factor was lower than among women (45.4 % and 52.8 %, respectively).Conclusions. For the first time, the features of the main risk factors for the development of chronic non-diseases were studied in an unorganized sample of the region’s population aged 25–64. Residents of the region have a high incidence of salt IBP, NPOF and elevated blood pressure. The ESSE-RF study made it possible to identify gender and territorial characteristics of our region. Thus, the study demonstrated that both sexes have NPOF and salt IBP, but smoking was more common among men, and high blood pressure among women. This study is the starting point for epidemiological studies in the Altai region and can serve as a guide for further monitoring of the prevalence of risk factors and the effectiveness of preventive programs.