Relevance. Chronic mechanical trauma of the oral mucosa is a serious disease that can occur when using removable orthopedic structures of various variations.Objective. Assessment of the symptoms of patients receiving local therapy, including the use of the domestic drug Superlymf adhesive plates.Materials and methods. In the course of a clinical study, a comparative analysis of the restoration of the oral mucosa was carried out in 4 groups of patients with different therapy options. A total of 52 people took part in the study. The observation was carried out for 14 days.Results. It was established that the group of patients who received complex treatment consisting of Metrogil-dental gel and Solcoseryl dental paste, as well as the group that used Superlymf alginate plates, showed the best results.Conclusion. The data obtained by us allow us to implement this treatment regimen for faster recovery of the mucous membrane in the presence of an injury from removable orthopedic structures.