As a traditional Chinese medicine (TCM), earthworm (Dilong) was applied in China for ages. Some active proteins and compounds in earthworm were characteristic composition as a pharmaceutical, including fibrinolytic enzymes, lumbrokinase, collagenase, superoxide dismutase, cholinesterase, catalases, glycosidases, metallothionein, calmodulin-binding protein, proteins with proliferation improving activity, lysenin, eiseniapore, antitumor protein, glycoprotein extract, gut mobility regulation peptide, antibacterial peptide, carbamidine, lumbritin, lumbrofobrim, terrestrolumbrolysin, purin, vitamin B, tyrosine, succinic acid, lauric acid, unsaturated fatty acid and so on. These earthworm components had more or less pharmacological and clinical functions on effects on the nervous system, blood system, the cardiovascular system, the respiratory system, uterus smooth muscle, and its anticancer function and sperm-killing function. Lumbricus metalchelatins (LMT) among these active components has detoxification function. LMT is one of the most common heavy metal detoxification, which are small cysteine-rich and non-ribosomal peptides that chelate soft metal and metalloid ions, such as cadmium, zinc and arsenic. LMT function of scavenging free radicals plays an important role in the process of the anti-aging, anti-oxidative stress and cell apoptosis, etc. No matter whole dry body or abstracted components, earthworm has been use to treat at least 19 human diseases in clinical, including treatments of tracheas, bronchial asthma, epilepsy, high blood pressure, schizophrenia, leg ulcers, mumps, eczema, urticaria and anaphylaxis diseases, chronic prostatitis, burns and scald, fractures, erysipelas, chronic lumbago, blood-deficiency apoplexy, acute injury of soft tissues, vertigo, hematemesis and hematuria, digestive ulcer, vesical calculus and cancer.