Objective: The purpose of this study was to evaluate the relationship between insulin resistance (IR) and the state of the global contractility and relaxation in patients with ischemic chronic heart failure (CHF). Design and method: The study involved 112 patients with documented coronary artery disease and heart failure at the age of 48 to 62 years. IR was verified by the homeostasis model assessment (HOMA-IR). Evaluation of hemodynamics was performed using transthoracic B-mode echocardiography with tissue Doppler imaging and Speckle Tracking imaging. Biomarker measurements were performed at baseline. Results: Univariable and multivariable Cox regression adjusted on NT-proBNP level has shown that IR (OR = 2.15; 95% CI = 1.05–3.22; p = 0.001), age (OR = 1.07; 95% CI = 1.03–1.10; p = 0.001) and NYHA class (OR = 1.03; 95% CI = 1.02–1.08; p = 0.001) predicted decrease in contractility function of LV in CHF patients. The independent predictors of declining of global longitudinal strain rate were IR (OR = 1.25; 95% CI = 1.11–1.89; p = 0.002), LVEF (OR = 1.05; 95% CI = 1.03–1.08; p = 0.002), NYHA class (OR = 1.07; 95% CI = 1.03–1.12; p = 0.001), and obesity (OR = 1.06; 95% CI = 1.02–1.10; p = 0.001). Therefore, IR (OR = 1.58; 95% CI = 1.13–2.64; p = 0.001), NYHA class (OR = 1.09; 95% CI = 1.03–1.17; p = 0.001), multi coronary vessel diseases (OR = 1.04; 95% CI = 1.00–1.09; p = 0.001) predicted decreasing of global circumferential strain rate. Conclusions: Insulin resistance in none-diabetes patients with CHF associates with sufficient disorders of integrated systolic and diastolic function of left ventricle.