Chronic Infectious Process Research Articles

Treatment of chronic suppurated otitis with fosfomycin.

A group of 24 patients with suppurated chronic processes of the medial ear have been treated with fosfomycin. All the cases were studied bacteriologically, isolating in the pus or exudates pathogenic bacterial flora, in which P. aeruginosa (40%) of the isolations) and S. aureus (23%) predominated. The sensitiveness of the strains isolated to fosfomycin was 94%. The results obtained were 21 clinical cures accompanied by the sterility of the exudates and 3 failures, which represents 87.5% success and 12.5% failures. These results are considered very satisfactory in view of the complexity and chronicity of the processes treated. It is also pointed out that fosfomycin totally lacks ototoxicity, being, therefore, a suitable antibiotic for treating chronic infectious processes of the ear.

Remarks on Chronic Infections

Excerpt The time-limits set for the presentation of this address have led the author to restrict his attention to a particular type or group of chronic infectious processes rather than to attempt a...

"FUNCTIONAL STUDIES THROUGHOUT THE COURSE OF ROENTGEN-RAY NEPHRITIS IN DOGS"

To the Editor: —In a recent paper (The Journal, January 15, p. 139) under the title given, Hartman, Bolliger and Doub have shown that chronic interstitial nephritis, quite typical of chronic interstitial nephritis in man, can be produced in dogs by exposing their kidneys to large doses of roentgen rays. These authors have thus produced in an experimental animal a lesion that promises for the first time to allow a more careful study of this disease. One question not discussed by them, or by others discussing their paper, is the significance of their work for a possible classification of chronic interstitial nephritis in terms of other pathologic processes peculiar to man. For a great many years it has been fully appreciated that the pathologic classification of nephritis does not fit the clinical pictures. Chronic interstitial nephritis is not a disease similar to the true chronic infectious processes from which the