Chronic granulomatous disease (CGD) is a genetically determined disorder characterized by a relative inability of the patient’s phagocytic cells to kill catalase-producing bacteria and fungi.(1) This decrease in intracellular killing leads to a marked increased susceptibility to infection. Gastrointestinal manifestations, such as colitis, have also been seen in CGD.(2) Typically, CGD patients with colitis are treated with steroids and antimicrobials, although this therapy is not uniformly successful.(2) Recently, cyclosporine has been used successfully to treat a single CGD patient with colitis who failed to respond to steroids.(3) We report another patient with CGD and intractable colitis who was successfully treated with cyclosporine, thereby providing additional evidence that cyclosporine may be effective therapy in such patients who are resistant to the usual modes of therapy.