Antecedentes El corazon pulmonar cronico (CPC) muestra un incremento en habitantes que viven en grandes altitudes. Objetivo Investigar la frecuencia de arritmias cardiacas y factores de riesgo para su desarrollo. Metodos Estudio descriptivo y transversal; se reviso el registro de pacientes internados del Departamento de Cardiologia del Instituto Nacional de Torax, La Paz, Bolivia, entre enero de 2017 y junio de 2018; se incorporo a todos los individuos con diagnostico de CPC, definido por criterios clinicos, electrocardiograficos y ecocardiograficos; se incluyo a 162 pacientes que cumplieron los criterios en el analisis; se utilizaron la t de Student y ANOVA. Resultados Arritmias: fibrilacion auricular (FA), 125 (75%); aleteo auricular (AA), 17 (10.5%); taquicardia auricular (TA), 17 (10.5%); extrasistoles, 3 (1.9%). Segun el analisis univariado, los factores relacionados con el desarrollo de arritmias fueron: eritrocitosis: FA, RR: 1.33, otras arritmias (RR: 1.67), p = 0.0001; hipertension arterial pulmonar: FA, RR: 3.10, otras arritmias (RR: 3.21), p = 0.0001; dilatacion de auricula derecha (AD): FA, RR: 1.92, otras arritmias (RR: 2.13), p = 0.0001; obesidad: FA, RR: 3.47, p = 0.001, otras arritmias (RR: 3.70), p = 0.001; hipertension arterial sistemica: FA, RR: 3.10, p = 0.001, otras arritmias (RR: 3.21), p = 0.001. Segun el analisis multivariado: eritrocitosis (RR: 2.2), dilatacion de AD (RR: 1.2), p = 0.0001. Conclusiones Se encontro FA con mayor frecuencia en los pacientes con CPC; los factores de riesgo con mayor significancia estadistica para su presentacion fueron la eritrocitosis y la dilatacion de la AD. Background Chronic cor pulmonale (CPC), with increased presentation in high-altitude inhabitants. Objectives Investigating the frequency of cardiac arrhythmias, and risk factors for its development. Methods Descriptive, cross-sectional study, the inpatient registry of the Department of Cardiology of the National Institute of Torax, La Paz-Bolivia, from January 2017 to June 2018 was reviewed, all were incorporated with the diagnosis of CPC, defined by clinical criteria, electrocardiographic and echocardiographic, 162 patients who met the criteria were taken, the student’s t-test and ANOVA were used for the analysis. Results Arrhythmias: atrial fibrillation (AF) 125 (75%), atrial flutter (AA) 17 (10.5%), atrial tachycardia (AT) 17 (10.5%), extrasystoles 3 (1.9%). Univariate analysis of factors related to the development of arrhythmias: erythrocytosis: FA, RR: 1.33, other arrhythmias RR: 1.67, p = 0.0001, pulmonary arterial hypertension: FA, RR: 3.10, other arrhythmias RR: 3.21, p = 0.0001, right atrial dilation (AD): FA, RR: 1.92, other arrhythmias RR: 2.13, p = 0.0001, obesity: FA, RR: 3.47, p = 0.001, other arrhythmias RR: 3.70, p = 0.001, systemic arterial hypertension: FA: RR: 3.10, p = 0.001, other arrhythmias RR: 3.21, p = 0.001. Multivariate analysis: erythrocytosis (RR: 2.2), AD dilation (RR: 1.2), p = 0.0001. Conclusions AF was found more frequently in patients with CPC, the risk factors with the greatest statistical significance for presentation were: erythrocytosis and AD dilation.