Chronic Bronchial Disease Research Articles

Sputum Cell Dynamics in Bacterial Exacerbations of Chronic Bronchial Disease

Qualitative and quantitative sputum cytologic and bacteriologic variables were determined in 38 patients with chronic bronchial disease. In each of 60 infectious exacerbations, three distinct periods were examined: stable phase (SS), bacterial (acute infections) exacerbation (AIE), and post-infection (PI). The neutrophil and histiocyte represent nonspecific cellular host defense but demonstrate different response patterns. Neutrophils increase significantly during AIE but return to SS levels by Pl. Histiocytes remain low during AIE but are elevated during Pl. Bronchial epithelial cells parallel the neutrophil change in AIE but do not return to SS levels by Pl. These measurements, along with the in vivo phagocytic indices (neutrophils and histiocytes with bacteria) and the infectivity index (bronchial epithelial cells with bacteria), provide direct objective criteria for evaluating the cellular dynamics of host defense in bronchopulmonary diseases.

Sputum cell dynamics in bacterial exacerbations of chronic bronchial disease

Sputum cell dynamics in bacterial exacerbations of chronic bronchial disease

Transtracheal Aspiration

Letters and Comments1 July 1970Transtracheal AspirationSTEPHEN G. PAUKER, M.D.STEPHEN G. PAUKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-1-142_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Hahn and Beaty (1) was a welcome substantiation of the validity of a technique that I have utilized with great success. It might be well to point out one potential danger of transtracheal aspiration and the usefulness of a closely related technique.If the intracatheter is introduced too deeply it may impinge on the posterior wall of the trachea, which may be lacerated if the patient moves or coughs. I am aware of one case where this resulted in an unrecognized hematoma in this position and lead to death by asphyxiation. This underscores...Reference1. HAHNBEATY HH: Transtracheal aspiration in the evaluation of patients with pneumonia. Ann Intern Med 72:183-187, 1870 LinkGoogle Scholar1. MAYMAY JD: Bacteriology of sputum in chronic bronchitis. Tubercle 44:162-173, 1963 CrossrefMedlineGoogle Scholar2. BRUMFITT W: An evaluation of sputum examination in chronic bronchitis. Lancet 2:1306-1309, 1957 CrossrefGoogle Scholar3. LEESMCNAUGHT AW: Bacteriology of lower respiratory tract secretions in "normals" and chronic bronchitics. Lancet 2:1112-1115, 1959 CrossrefMedlineGoogle Scholar4. ALLIBONEALLISONZINNEMANN ECK: Significance of H. influenzae in bronchiectasis of children. Brit Med J 1:1457-1460, 1956 CrossrefMedlineGoogle Scholar5. TURKMAY DJ: Haemophilus influenzae, Its Clinical Importance, London, The English Universities Press, Ltd., 1967, pp. 43-44 Google Scholar6. CHODOSH S: Examination of sputum cells. New Eng J Med 282:854-857, 1970 CrossrefMedlineGoogle Scholar7. Editorial: Transtracheal aspiration. New Eng J Med 269:203, 1963 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byINVASIVE PROCEDURES FOR DIAGNOSING PULMONARY INFECTIONUsefulness of transtracheal puncture and aspiration in the bacteriological diagnosis of pulmonary tuberculosisAnaerobic bacteriology of chronic bronchial disease 1 July 1970Volume 73, Issue 1Page: 142-143KeywordsTrachea Issue Published: 1 July 1970 PDF downloadLoading ...

Capsulated Haemophilus influenzae and bronchiectasis.

Summary Thirty-four patients with bronchiectasis were studied for periods of up to 5 yr in an attempt to determine the part played by capsulated strains of Haemophilus influenzae in this disease and the consequent likelihood that type-specific immunisation against such strains would be beneficial. Capsulated haemophili were isolated from sputum from only 5 of the 34 patients and fourfold or greater rises of capsular antibody were observed in only 10 of 33 of the patients who were subjected to repeated serological examinations. These findings indicate that infection of the patients' respiratory tracts with capsulated strains was not unduly common during the period of the study. The patients as a group did not differ significantly in their serum titres of haemophilus capsular antibody from control groups of subjects without lower respiratory tract disease, and therefore had almost certainly not had a greater than usual experience of capsulated haemophili. These findings are in sharp contrast to the existing evidence about the role of the species H. influenzae in chronic bronchial disease, and appear to indicate that capsulated haemophilus strains differ from non-capsulated strains in playing no part in bronchiectasis.

Sweat Chloride in Patients with Chronic Bronchial Disease and Its Relation to Mucoviscidosis (Cystic Fibrosis)

Sweat Chloride in Patients with Chronic Bronchial Disease and Its Relation to Mucoviscidosis (Cystic Fibrosis)

Sweat chloride in patients with chronic bronchial disease and its relation to mucoviscidosis (cystic fibrosis).

Sweat chloride in patients with chronic bronchial disease and its relation to mucoviscidosis (cystic fibrosis).

The significance of Haemophilus influenzae in chronic respiratory disease as elucidated by serologic tests.

By simultaneous examination of bronchoscopic aspirates, sputum samples, and throat swabs in a material of patients with chronic bronchial disease, together with determinations of antibodies against the common pathogenic bacteria of the respiratory tract the following facts emerge:The combined results of cultures from throat swabs and sputum samples reflect poorly the bacterial flora found in bronchial secretion.Among potentially pathogenic bacteria H. influenzae and pneumococci were most often recovered from bronchial secretion, the former especially so in comparison with its occurrence in throat swabs and sputum.The occurrence of H. influenzae in bronchial aspirates was correlated to elevated titres of homologous antibody. No such correlation existed between findings of this organism in sputum and throat swabs on one side, and homologous titres on the other.As to other bacteria studied there was no correlation between their occurrence in any material cultivated and elevations of the homologous antibody t...

LABORATORY DIFFERENTIATION OF CHRONIC BRONCHIAL DISEASE AN INVESTIGATION OF 117 CASES

LABORATORY DIFFERENTIATION OF CHRONIC BRONCHIAL DISEASE AN INVESTIGATION OF 117 CASES