ABSTRACT The present work analyzes the magnetized Casson-Williamson nanofluid flow past permeable and exponentially stretching devices. Microorganisms are immersed to improve the stability of nanoparticles. The novel effect of frictional forces working between the fluid layers is described using the Cattaneo – Christov heat flux model. The energy equation consists of viscous dissipation and Joule heating effect in the system. Further, thermal radiation and chemical reaction effects are considered during the mathematical framing. The nanofluid characteristics are elaborated using the Buongiorno nanofluid model. Thus, the obtained governing system of equation is further renovated using the similarity invariants. The graphical illustrations of the numerical outcomes are obtained in MATLAB. The code validation is carried out with a numerical comparison between the recent publications. Our results show that the fluid temperature enhances with higher values of thermophoresis, Brownian motion parameter, Rayleigh number, Eckert number, and Joule heating. The velocity declines with an increase in the strength of the magnetic field.