Multiple orthogonality is considered in the realm of a GaussâBorel factorization problem for a semi-infinite moment matrix. Perfect combinations of weights and a finite Borel measure are constructed in terms of M-Nikishin systems. These perfect combinations ensure that the problem of mixed multiple orthogonality has a unique solution, that can be obtained from the solution of a GaussâBorel factorization problem for a semi-infinite matrix, which plays the role of a moment matrix. This leads to sequences of multiple orthogonal polynomials, their duals and second kind functions. It also gives the corresponding linear forms that are bi-orthogonal to the dual linear forms. Expressions for these objects in terms of determinants from the moment matrix are given, recursion relations are found, which imply a multi-diagonal Jacobi type matrix with snake shape, and results like the ABC theorem or the ChristoffelâDarboux formula are re-derived in this context (using the factorization problem and the generalized Hankel symmetry of the moment matrix). The connection between this description of multiple orthogonality and the multi-component 2D Toda hierarchy, which can be also understood and studied through a GaussâBorel factorization problem, is discussed. Deformations of the weights, natural for M-Nikishin systems, are considered and the correspondence with solutions to the integrable hierarchy, represented as a collection of Lax equations, is explored. Corresponding Lax and ZakharovâShabat matrices as well as wave functions and their adjoints are determined. The construction of discrete flows is discussed in terms of Miwa transformations which involve Darboux transformations for the multiple orthogonality conditions. The bilinear equations are derived and the Ï-function representation of the multiple orthogonality is given.
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