Relevance. Diseases of the circulatory system occupy a leading place in the structure of somatic pathology of liquidators. Obesity, signs of asthenization, vegetal vascular disorders, which were detected in numerous studies, suggest the presence of hypogonadism in this category of victims. Sex hormone deficiency is considered an important link in the formation of non-communicable diseases, which determined the relevance of the study.The goal. To carry out a retrospective assessment of the change in the hormonal indicators of the endocrine axis of hypophysis-sex hormones and to assess the effect of partial androgen deficiency on the formation of circulatory diseases in the dynamics of the examination in the liquidators of the consequences of the Chernobyl accident.Materials and methods. Hormonal indicators of the pituitary-gonadal endocrine axis were investigated by immunochemical analysis in 1065 men involved in the aftermath of the Chernobyl accident in 1986–1987, combined into groups depending on the period of examination from 1994 to 2019 and in control groups. The average age of patients entering the Chernobyl zone was 33.6 (0.8) years.Results. Seven years after the accident, liquidators in 13.1 % cases show a shortage of sex hormones, by 33 years of follow-up, the proportion of such patients increases by 4.6 times. Sex hormone deficiency 7 years after the accident was revealed in men of relatively young age, the correlation of testosterone levels with the concentration of gonadotropins and prolactin has not been established. The increase in prolactin in the liquidators of the consequences of the Chernobyl accident, reliable in relation to the control group, remains for 12 years after the accident. 30–33 years after the accident, participants in the elimination of the consequences of the Chernobyl accident have significant age-related changes in hormonal indicators, among which the main is partial androgen deficiency.Conclusions. The persistent imbalance of hormones of the pituitary-gonadal endocrine axis at the time of 1994–1998 contributed to the clinical manifestation of circulatory diseases in liquidators – middle-aged men, clinical symptoms, on the other hand, aggravated diverse shifts in the functioning of this endocrine axis of regulation. In the later period of observation by 30–33 years after the accident, a decrease in androgen levels was accompanied by a steady increase in circulatory diseases in liquidators.