Milk Cholesterol Content Research Articles

Effect of Dietary Fat and Cholesterol on Milk Composition, Milk Intake and Cholesterol Metabolism in the Rabbit

Sixteen female rabbits were fed one of four diets during lactation: 1) a commercial stock diet; 2) the stock diet with 5% added lard; 3) the stock diet with 5% lard and 0.25% cholesterol; or 4) the stock diet with 15% lard and 1% cholesterol. By days 30–35 of lactation, maternal plasma cholesterol concentrations were increased approximately 10-fold in group 3 and 100-fold in group 4 does compared to does in group 1. Milk cholesterol concentration was similar over lactation for does in groups 1, 2 and 3, but was approximately 2 times higher in group 4 does. Milk triglyceride and protein concentrations and milk intake by the pups were not significantly influenced by maternal diet. Average cholesterol intake of pups nursed by group 4 does was significantly higher than that of other pups. Although plasma cholesterol concentration was significantly increased in group 2, 3 and 4 pups at weaning (age 5 weeks), there was no significant effect of maternal diet on plasma cholesterol at 6, 7 or 11 weeks of age after pups had been weaned to the stock diet. Similarly, liver cholesterol concentration was increased in pups from group 4 does at weaning, but these differences were no longer apparent at 11 weeks of age. These data suggest that severe maternal hypercholesterolemia induced by dietary fat and cholesterol in the rabbit can result in increased milk cholesterol concentration and consequent cholesterol intake by the pups. However, the associated elevations in pup plasma and liver cholesterol levels at weaning did not persist when pups were weaned to a low fat/low cholesterol diet.cholesterol milk composition maternal hypercholesterolemia

Influence of Dietary Fat and Cholesterol on Milk Lipids and on Cholesterol Metabolism in the Rat

The experimental basis for a hypothesis of Reiser and Sidelman (J. Nutr. 102: 1009, 1972) that cholesterol intake early in life is inversely related to an animal's subsequent hypercholesterolemic response to dietary cholesterol was tested. Female rats (seven per group) were fed either a stock diet (group 1), a semisynthetic diet with 15% lard (group 2) or the semisynthetic diet with 15% lard and 1.5% cholesterol (group 3) from day 18 of gestation and during lactation. Plasma cholesterol concentration during lactation was significantly higher in group 3 dams, but there were no significant effects of maternal diet on milk cholesterol or triglyceride concentration. Pups had access to the dams' diets until weaning at 30 days of age. Plasma and liver cholesterol concentrations at weaning were significantly higher in pups from group 3 dams than in those from the other groups. All pups were fed a semisynthetic diet containing 10% lard and 0.5% cholesterol from 60 to 161 days of age. Plasma cholesterol concentration during this time was significantly lower in male pups from group 1 dams than in those from other dams. Plasma cholesterol concentration in female pups showed a similar trend and was, on the average, significantly higher in females than males. Pup liver cholesterol concentration after weaning was not significantly influenced by maternal diet. Thus, these data do not support the hypothesis that cholesterol intake in early life is inversely correlated with subsequent response to dietary induced hypercholesterolemia.dietary cholesterol hypercholesterolemia

The cholesterol content of human milk. A variable constituent among women and within the same woman.

The cholesterol content of human milk. A variable constituent among women and within the same woman.

The effects of dietary fatty acids and cholesterol on the milk lipids of lactating women and the plasma cholesterol of breast-fed infants

The plasma cholesterol concentration and the composition of the plasma fatty acids was altered by dietary means in 10 lactating women. The effects of these changes in the plasma on the lipid constituents of mature human milk were studied over periods of several weeks. In eight infants who were being breast-fed, the changes in the plasma cholesterol concentration were correlated with the changes that were induced in the milk lipids. Significant alteration in the women's plasma cholesterol levels did not change the cholesterol concentration in milk. The cholesterol content of milk was closely correlated with the concentrations of the other milk lipids, supporting a functional role for the cholesterol in the secretion of milk fat. In the maternal milk consumed by the eight infants the linoleate content rose from 9.4% to 15.5% of total fatty acids as a result of a moderate increase in dietary polyunsaturated fat. This led to a fall in the infants' plasma cholesterol levels, from an average of 185 to 157 mg/100 ml.

The free and ester cholesterol content of milk and dairy products

Free and total cholesterol contents of milk and a number of dairy products were determined. 5–10% of the total cholesterol was found present in the ester form in Cheddar cheese, butter and butterfat, and there is no evidence that this ratio was different from one dairy product to another. The results of these analyses were confirmed by thin layer chromatography.

The Cholesterol Content of Human Milk

Research Article| January 01 1924 The Cholesterol Content of Human Milk Francis William Fox; Francis William Fox 1The Chemical Department, St George's Hospital Search for other works by this author on: This Site PubMed Google Scholar John Addyman Gardner John Addyman Gardner 1The Chemical Department, St George's Hospital Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1924) 18 (1): 127–135. https://doi.org/10.1042/bj0180127 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Francis William Fox, John Addyman Gardner; The Cholesterol Content of Human Milk. Biochem J 1 January 1924; 18 (1): 127–135. doi: https://doi.org/10.1042/bj0180127 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1924 CAMBRIDGE UNIVERSITY PRESS1924 Article PDF first page preview Close Modal You do not currently have access to this content.