The vertical flow of mud and gas-mud mixtures in long pipes is of interest in the design and operation of subsea well control equipment where long choke lines are required. Heretofore, the question of two-phase flow of non-Newtonian drilling muds has not been investigated experimentally in full-scale well systems. Frictional-pressure losses were measured in a 2 3/8-in., 3000-ft long, vertical tubing when flowing drilling mud alone, and flowing mud-gas mixtures. The single-phase data was compared to values predicted by both the Bingham plastic and power law rheological models, which are commonly used to describe non-Newtonian fluids. The multiphase pressure loss data were used to evaluate various published correlation techniques.