Choice Of Options Research Articles

Dental Management of Pedatric Patient with Autism Spectrum Disorder under General Anesthesia: A Case Report

Autism spectrum disorder or autism, corresponds to "a pervasive developmental disorder (PDD), characterized by an abnormal or a deficient development. It is manifested before the age of three, with a characteristic disturbance in the functioning of each of the following three areas: social interaction, verbal and non-verbal communication, and restricted and repetitive behaviors. The combination of these three elements corresponds to the autistic triad. The latter appears in different forms, with varying degrees of severity, and can also vary with age. The oral care of this patient remains delicate, due to the difficulty of communication and the apprehension of his behavioral response. The young female, 13 years old and in good general health, presented to the dental center of Cheikh Khalifa Hospital with spontaneous pain in the right mandibular and left maxillary sectors. She was diagnosed with one of the autistic spectrum disorders: Asperger's syndrome. In our case, the patient was uncooperative and unable to attend the dental treatment in a vigorous state or under conscious sedation. General anaesthesia was the choice option. This last resort allows the patient to lose consciousness, eliminates pain and relaxes the muscles, making dental treatment a pleasant experience. The aim of this poster is to illustrate, through a case study, the protocol for managing a patient with autism spectrum disorder, and to demonstrate the indication for general anesthesia in the treatment of this patient.

Achieving HIV epidemic control through accelerating efforts to expand access to pre-exposure prophylaxis for people who inject drugs

The world is not on track to reach the majority of the UNAIDS 2025 targets, and people who inject drugs (PWID) continue to be left behind, hindered by counterproductive law enforcement practices, punitive laws, economic distress, and social stigma and discrimination. Poor access to HIV pre-exposure prophylaxis (PrEP) among PWID is nested within the limited access to broader harm reduction services, including needle and syringe programs, opioid overdose management, opioid agonist therapy (also known as medication-assisted treatment), and condoms. Among PWID, women who inject drugs are disproportionately affected and face additional gender-based barriers. Intersections between PWID and other key and priority population groups also exist. Although the prioritization of PWID for new PrEP products like the dapivirine vaginal ring and injectable cabotegravir has lagged in research, studies have shown that PWID find injectable and long-acting options acceptable and preferrable, including among women who inject drugs. While new PrEP products introduce new opportunities, equity in access must be assured for optimized impact toward achieving epidemic control. Programming for services must engage and empower PWID community leadership to address the structural barriers to services, implement community-led, differentiated, and integrated service modalities, and offer the choice of all harm reduction options to close the equity gaps in health outcomes. While waiting for necessary evidence and approvals, programs should work together with the PWID community to prioritize, expand, and facilitate efforts and investments toward increased access to and integration of PrEP and all recommended harm reduction services for PWID.

Research on the Corrosion Resistance and Cytotoxicity of Medical Forged Co-28Cr-6Mo Alloy

Co-Cr-Mo alloy as a human body implant material has a long history, because of its excellent corrosion resistance and biocompatibility, and is widely used in human hip joint materials. Co-Cr-Mo alloy in the human body is often in a passivation state; the formation of dense oxide film on the alloy surface prevents further corrosion of the alloy. The main component of the passivation film is the oxide of Cr, so a layer of oxide film formed by Cr on the surface of Co-Cr-Mo alloy is the reason for its good corrosion resistance. In biocompatibility, cytotoxicity is the first choice and necessary option for biological evaluation, and cytotoxicity can quickly detect the effect of materials on cells in a relatively short time. Therefore, this research conducted a comparative evaluation on the corrosion resistance and biocompatibility of forged Co-Cr-Mo alloys produced in domestic and foreign alloys in line with medical standards. Three simulated human body fluids and Princeton electrochemical station were selected for corrosion resistance experiments, and it was found that the corrosion resistance of four alloys in sodium citrate solution inside and outside China would be reduced. All the alloys exhibit secondary passivation behavior in Hanks solution, which improves the corrosion resistance of the alloys. According to the self-corrosion potential Ecorr analysis, the corrosion resistance of domestic B alloy is the best, while that of foreign R31537 alloy is poor. In the biocompatibility experiment, the biocompatibility of Co-Cr-Mo alloy was evaluated through the measurement of contact Angle and cytotoxicity reaction. The experimental results show that Co-Cr-Mo alloy is a hydrophilic material, and the contact Angle of foreign R31537 alloy is smaller, indicating that the surface of R31537 alloy is more suitable for cell adhesion and spreading. According to the qualitative and quantitative analysis of the cytotoxicity experiment, the toxic reaction grade of domestic A, B and R31537 alloy is grade 1, the toxic reaction grade of C alloy is grade 2, and C alloy has a slight toxic reaction.

SICOB Italian clinical practice guidelines for the surgical treatment of obesity and associated diseases using GRADE methodology on bariatric and metabolic surgery.

Obesity is a chronic disease associated with increased morbidity and mortality and reduced quality of life. Pharmacotherapy can be associated with life style changes in increasing and maintaining weight loss and ameliorating obesity-related complications and comorbidities. In patients affected by obesity and uncontrolled obesity-associated complications or high degrees of BMI (> 40 Kg/m2), metabolic bariatric surgery can be a valid therapeutic option. Many different types of surgical procedures have been developed in last decades, mainly performed via laparoscopic approaches. However, clinical indications for metabolic and bariatric surgery (MBS) and the choice of the most appropriate type of procedure have not been clarified so far.The Italian Society of Bariatric and Metabolic Surgery for Obesity (Società Italiana di Chirurgia dell'Obesità e delle Malattie Metaboliche-SICOB) decided to design and develop the updated version of the Italian guidelines aimed at assisting healthcare professionals in the choice of the surgical option for the treatment of obesity and related conditions. Between June and October 2022, a panel of 24 experts and an evidence review team (ERT, 10 members), participated in the definition of clinical questions, outcomes, and recommendations and collected and analyzed all the available evidence on the basis of pre-specified search strategies. GRADE methodology and PICO (Patient, Intervention, Comparison, Outcome) conceptual framework have been adopted for the development of the present guidelines. Aim of the present guideline is to verify indications to surgery with respect to the presence of comorbid conditions, evaluate the different types of surgical approaches and endoscopic bariatric procedure and revise indication to revision surgery and postoperative procedures.

Analysis of early and treatment related deaths among children and adolescents with acute myeloid leukemia in Poland: 2005–2023

BackgroundA personalised approach to the treatment of acute myeloid leukemia (AML) in children and adolescents, as well as the development of supportive therapies, has significantly improved survival. Despite this, some patients still die before starting treatment or in an early phase of therapy before achieving remission. The study analysed the frequency, clinical features and risk factors for early deaths (ED) and treatment related deaths (TRD) of children and adolescents with AML.MethodsFrom January 2005 to November 2023, 646 children with AML treated in the centers of the Polish Pediatric Leukemia and Lymphoma Study Group according to three subsequent therapeutic protocols were evaluated: AML-BFM 2004 Interim (385 children), AML-BFM 2012 Registry (131 children) and AML-BFM 2019 (130 children).ResultsOut of 646 children, early death occurred in 30 children, including 15 girls. The median age was 10.7 years (1 day to 18 years). More than half of the patients (53%) were diagnosed with acute myelomonocytic leukemia (M5) and 13% with acute promyelocytic leukemia (M3). The ED rate for the three consecutive AML-BFM protocols was 4.9% vs. 5.3% vs. 3.1%, respectively. In 19 patients, death occurred before the 15th day of treatment, in 11 between the 15th and 42nd day. The most common cause of death before the 15th day (ED15) was leukostasis and bleeding, whereas between the 15th and 42nd day (ED15-42), infections, mainly bacterial sepsis. A significant association was found between ED15 and high leukocyte count (>10 × 109/L), M3 leukemia (p < 0.001), and ED15-42 and age <1 year (p = 0.029). In the univariate analysis only initial high leukocyte count >100 × 109/L, was a significant predictor of early death. The overall TRD for the entire study period was 3.4%. The main cause of death were infections, mainly bacterial sepsis (10 children out of 22, 45.4%).ConclusionsHyperleukocytosis remains significant factor of early mortality in patients with AML, despite the introduction of various cytoreductive methods. Infections are still the main cause of treatment related deaths. A more individualized approach by using new targeted drugs may be the therapeutic option of choice in the future.

Interaction of Cognitive and Motivational Processes in Asymmetric Preferences for Gains and Losses

An experiment on repetitive decision-making was conducted to explore the interaction between cognitive and motivational processes in decision-making. The gain-loss framing of risky choice options was manipulated to investigate cognition, and participants’ chronic regulatory focus was measured to assess motivation. Risky choice demonstrated interactive effects between gain-loss framing and regulatory focus. Participants made less risky or riskier choices in the gain or loss condition, respectively. Furthermore, promotion or prevention-focused individuals chose the risky option more frequently in the gain or loss condition, respectively. The results for response times showed the main effects for the two factors, with no interaction. These results, along with supplementary post-hoc analyses, provide evidence that cognitive and motivational processes are simultaneously involved in risky decision-making.

An optional choice for closing the duodenal defect after endoscopic full-thickness resection: endoscopic hand-suturing.

An optional choice for closing the duodenal defect after endoscopic full-thickness resection: endoscopic hand-suturing.

Public Rights Orientations and Views on Long‐Term Care Options for Children in the Child Protection System: An Analysis of Representative Samples of Adults in California, USA and Norway

ABSTRACTThis study examines a representative sample of adults in California (USA) and Norway, and their attitudes toward adoption versus foster care in a child protection case. The results show that a majority of people favour adoption for a child who has been removed due to maltreatment and cannot be reunified with birth parents. The study examines if people's rights orientation, favouring children or adults, or favouring birth parents or adoptive parents, or their institutional context explain their preferences about long‐term care options. Data material consist of representative samples of the population in California (USA) and Norway (n = 2222), using a vignette survey design. Findings suggest that individuals with a child rights position favour adoption, but attitudes about birth parents' and adoptive parents' rights are not related to care option choices. Institutional context, anchored in policy feedback literature, partly explains the preference for adoption and the population's rights orientation. Further studies are necessary to confirm the role of rights attitudes and institutional context.

7341 Establishing a Multidisciplinary Care Program for patients with Klinefelter Syndrome and other Aneuploidy X and Y Variations

Abstract Disclosure: C.J. Romero: None. N.R. Malhotra: None. A. Norris-Brilliant: None. C. Mintz: None. Objectives: Klinefelter syndrome (KS) is one of the most common genetic aneuploidies denoted by a XXY karyotype and affects up to 1 in 600 patients. Most patients are not diagnosed until adolescent years or adulthood. KS is one of the leading causes of male infertility and testosterone insufficiency. KS is also associated with developmental delays, particularly speech and language delay. Advances in genetics screenings has led to early identification of KS and other aneuploidy X and Y variations, access to neurodevelopmental screening and fertility preservation resources during adolescence and young adulthood. We believe a multidisciplinary program for KS can provide the necessary resources for patients and families at any age from infancy to young adulthood. Methods: A group of faculty from the divisions of pediatric endocrinology, genetics, urology and psychiatry assembled in 2023 to establish a multidisciplinary clinic (MDC) to provide comprehensive care to patients/parents; this ranged from prenatal diagnosis to young adulthood. Two major challenges of care are access to neuro-psychological evaluations and fertility preservation options. Testosterone supplementation requires appropriate referral to endocrinology and timing of treatment remains controversial. Our goals include: expertise guidance and planning after prenatal diagnosis or later in age; access to cost effective neuro-psychological testing during early childhood years; urological consultation beginning in early puberty to educate and prepare patients for choices of surgical and non-surgical options of fertility preservation. Results: Our current center cares for 12 patents ranging from ages 3 months to 21 years. Of this cohort, 3 (25%) of the patients had initial consultations with the parents during pregnancy. 7 (58%) of the patients were of pubertal age that one would consider testosterone replacement, but only 3 (43%) were taking testosterone. Only 1 patient of school age reported neuro-psychological evaluation that was completed at a different institution. No patients received testosterone supplementation during year one of life. Conclusions: A multidisciplinary team can offer simultaneous assessment, anticipatory guidance and management for KS patients and their families. It is a comprehensive resource to our community. Prenatal genetic screenings bring awareness to this diagnosis and therefore timely education toward understanding the lifelong management of KS. Identifying developmental delays early in childhood will help with scholastic success. Monitoring of pubertal development will ensure appropriate pubertal progression in addition to education and management of fertility preservation. Undoubtedly future urological advances will assist patients more effectively. We believe our model provides the access to resources that allow our patients and family to successfully thrive. Presentation: 6/2/2024

A dynamic discrete choice modelling approach for forward-looking travel mode choices

In this paper, we present a systematic approach based on dynamic discrete choice models (DDCM) to investigate individuals’ forward-looking mode choice behaviours in daily travel tours with multiple destinations. We propose a novel network transformation model that encompasses the entire decision space of all feasible mode combinations for every observed trip/tour in the dataset. By applying the well-established Recursive Logit model structure commonly used in path choice modelling, we address the tour mode choice problem effectively and quantify forward looking considerations in the mode choice process. The proposed model captures the complex considerations individuals take into account when making mode choices. The network transformation incorporates downstream mode limitations into the preceding mode choice options, enabling us to model individuals’ forward-looking behaviour and gain insights into how considerations of future trips such as a shopping in the evening, or school pick-up trip influence previous mode choice decisions earlier in the day. Uncovering and quantifying these hidden forward-looking factors can help modellers better explain the private car usage usually observed for the entire sequences of daily trips, even in presence of competitive alternative modes. The proposed network transformation also enables us to measure the effect of the requirement/preference to return private vehicles (car, motorcycle, and bicycle) home on mode choices in home-bound trips, and subsequently, on the entire daily mode choice decisions. To validate the proposed model, we utilise the VISTA household travel survey data from the Melbourne Metropolitan area in Australia. The model is compared against baseline models, demonstrating its statistical advantages. Additionally, intuitive illustrations using the data showcase the model’s efficacy. From transport planning and policy perspective, tour-based mode choice modelling provides a more comprehensive and precise understanding of travel behaviour by considering the sequence of trips made by an individual. This can help capture the interactions and dependencies between different trips, which trip-based models may overlook. The proposed model is more suitable for analysing the effects of policy interventions like congestion pricing, public transport investments, or new mobility initiatives, as they can better represent the cascading effects of such policies across multiple trips.

Dynamic choice HIV prevention with cabotegravir long-acting injectable in rural Uganda and Kenya: a randomised trial extension

HIV infections are ongoing globally despite efficacious biomedical prevention options. We sought to determine whether an HIV prevention package providing choice of daily pills or long-acting injectable cabotegravir and opportunities to change prevention options could increase biomedical prevention coverage and reduce new HIV infections. This study was an extension of three randomised trials that used SEARCH dynamic choice HIV prevention to recruit adults (aged ≥15 years) at risk for HIV from antenatal, outpatient, and community settings in rural Uganda and Kenya. In this 48-week open-label extension, participants maintained their original (1:1) randomisation group; the option to choose cabotegravir long-acting injectable was added for intervention participants. Inclusion criteria for the extension were previous enrolment in a SEARCH dynamic choice HIV prevention trial, negative HIV rapid test, and residence in study region. The intervention provided person-centred choice of oral pre-exposure prophylaxis (PrEP) or post-exposure HIV prophylaxis (PEP) or cabotegravir long-acting injectable, with the option to switch according to participant preference. The control provided standard-of-care access to oral PrEP and PEP, but not cabotegravir long-acting injectable. Biomedical prevention coverage (proportion of follow-up covered by oral PrEP, PEP, or cabotegravir long-acting injectable; primary outcome) and HIV incidence (secondary outcome) were compared between groups using targeted minimum loss-based estimation. The trial (NCT05549726) is closed to recruitment. Of 1534 participants initially randomly assigned (from April 15, 2021 to Sept 29, 2022), 984 (487 in the intervention group and 497 in the standard-of-care group) reconsented to the extension (from Jan 2 to March 3, 2023). The mean proportion of follow-up covered by biomedical HIV prevention was 69·7% (95% CI 64·9-74·5) in the intervention group versus 13·3% (10·2-16·3) in the standard-of-care group, corresponding to an absolute difference of 56·4 percentage points (95% CI 50·8-62·1; p<0·0001). The intervention significantly improved coverage across prespecified subgroups (sex and age groups). During the study, 274 (56%) of 485 intervention participants used cabotegravir long-acting injectable, 255 (53%) used oral PrEP, and ten (2%) used PEP. Among cabotegravir long-acting injectable initiators, 118 (43%) of 274 were not previously using oral PrEP or PEP. There were seven incident HIV infections in 390 person-years of follow-up in the standard-of-care group and no infections in 400 person-years of follow-up in the intervention group (incidence rate difference per 100 person-years 1·8, 95% CI 0·4-3·2; p=0·014). Offering people the choice of HIV biomedical prevention options including cabotegravir long-acting injectable in a flexible model can increase prevention coverage and reduce incident HIV infections. HIV programmes should support dynamic choice HIV prevention programmes that include effective oral and injectable long-acting products. National Institutes of Health.

Not-so-speedy delivery: Should retailers use discounts or donations to incentivize consumers to choose delayed delivery?

Many retailers feel the pressure to provide increasingly speedy delivery, but the realities of speedy delivery logistics are costly, complicated, and uncertain. In response, retailers have been using discounts to nudge consumers’ voluntary choice of a slower delivery option, but with tepid results. The current research argues that a better incentive exists. Data from six studies demonstrate that changing from a discount (the retailer giving the consumer a $1 reward/coupon) to a donation (the retailer donating $1 to a charity) incentive significantly increases the voluntary choice of delayed delivery. Importantly, the data shows that exchange equity drives this effect. However, two boundary conditions are identified: 1) the retailer communicating a reason for the delayed delivery and 2) the type of product being purchased by the consumer. In sum, the current research provides actionable insights for retailers that offer a delayed delivery option to consumers during checkout and speaks to the current debate about consumers’ desire for speedy delivery.

Management of Bone Bridge Exposure Using Superficial Temporal Island Flap After Auricle Reconstruction and Bone Bridge Implantation.

Congenital microtia usually lead to impairment of both appearance and hearing especially for patients with bilateral microtia. The simultaneous combination of auricular reconstruction and bone bridge implantation has been proved effective and satisfied with the patients. We retrospectively analyzed this method and the complication of it. We summarized and found the application of superficial temporal island flap for repairing the bone bridge exposure. From January 2017 to December 2020, there were 84 patients who underwent the surgery of auricular reconstruction simultaneously combined with bone bridge implantation in the Plastic Surgery Hospital of Chinese Academy of Medical Sciences. And after 12 months follow-up, we evaluated the postoperative effect and collected data on the patients who had bone bridge exposure. We analyzed the reason of the complication and covered the exposed bone bridge with superficial temporal island flap. There were 3 cases (3.6%) of implant exposure and the surgical outcome was satisfactory using the repairment of superficial temporal island flap. All 3 patients were healed in 1-stage surgery, and no further implant exposure occurred after another 12-month follow-up. The method of auricular reconstruction simultaneously combined with bone bridge implant is an optional choice for patients with bilateral microtia, and has a low incidence of implant exposure. The superficial temporal island flap could well fill the dead space and increase the wear resistance of the tissue, and the scar was not obvious. We found and summarized a satisfactory method of repairing the implantation exposure using the superficial temporal island flap. Level IV, cases study.

Применение большого количества методов оперативного лечения стриктуры уретры у одного пациента: клинический случай

Introduction. Insufficient surgical experience and inadequate choice of surgical treatment options may be the reasons for the failure of treatment of urethral stricture. In this regard, a clinical case from our practice is very indicative. Case: The article is devoted to the description of a clinical case of urethral injury in a man who, at the age of 22 years, suffered a fracture of the pelvic bones as a result of a traffic accident. From the moment of injury to the final operation, the following types of surgical interventions were sequentially performed in this patient: anastomotic endto-end urethroplasty, augmentation urethroplasty using a skin graft, augmentation urethroplasty using a graft of the tunica vaginalis of the testicle, bougienage of the urethra, urethroplasty with a vascularized radial fasciocutaneous flap on a vascular pedicle, 2-stage urethroplasty using a graft of the buccal mucosa according to the type of Bracka I and II operations, perineal urethrostomy. Urethrostomy became the final option for urine diversion; no recurrence of urethral stricture was observed during 4 years of follow-up after urethrostomy. Conclusion. Until recently, the lack of uniform approaches to the treatment of urethral stricture has led to the use of inadequate methods of surgical treatment in various clinics. The recent approval of federal clinical guidelines for urethral stricture should help optimize the treatment of this disease. Keywords: urethral stricture, urethroplasty, urethrostomy

Small-scale farmers perception, adaptation choices to climate change and existing barriers: Evidence from northern Ethiopia

Climate change continues to significantly impact agricultural production in Ethiopia that have encountered several environmental problems in recent decades. The study site is one of the areas vulnerable to climate change and influenced by climate variability. This study intends to identify small-scale farmers’ adaptation options, their perception and existing barriers in northern Ethiopia. It is based on an analysis of cross-sectional data collected from 193 randomly selected farm household heads. A multivariate probit model was employed to analyze the factors influencing farmers’ climate change adaptation choices. Constraint Facing Index (CFI) technique was also constructed to identify the existing barriers. The findings indicate that a significant number of farmers (91.2%) reported a trend toward rising temperatures. Similarly, 86.01% of the farmers indicated that the perceived rainfall trend has decreased. Adjusting planting dates (56.5%), integrated soil fertility management practices (47.7%), early maturing crop varieties (53.4%), terracing for soil and water conservation (54.9%), and income diversification (55.4%) were the most common climate change adaptation options practiced by farm households in the study area. Some of these adaptation options have significant and complementary relationships. The farmer’s choice of adaptation option was highly constrained by institutional factors and all these identified factors can be possibly addressed through a better institutional service provision system, for a better farm-level adaptation while considering demographic characteristics as well.

Generalized Encoding of the Relative Subjective Value of Cognitive Effort in the Dorsal ACC.

Making choices about whether and when to engage cognitive effort are a common feature of everyday experience, with important consequences for academic, career, and health outcomes. Yet, despite their hypothesized importance, very little is understood about the underlying mechanisms that support this form of human cost-benefit decision-making. To investigate these mechanisms, we used the Cognitive Effort Discounting Paradigm (Cog-ED) during fMRI scanning to precisely quantify the neural encoding of varying cognitive effort demands relative to reward outcomes, within two distinct cognitive domains (working memory, speech comprehension). The findings provide strong evidence that the dorsal anterior cingulate cortex (dACC) plays a central and selective role in this decision-making process. Trial-by-trial modulations in dACC activation tracked the relative subjective value of the low-effort, low-reward option, with the strongest activity occurring when this was of greater value than the high-effort, high-reward option. In contrast, dACC activity was not modulated by decision difficulty, though such effects were found in other frontoparietal regions. Critically, dACC activity was also strongly correlated across the two decision-making task domains and further predicted subsequent choice behavior in both. Together, the results suggest that dACC activity modulation reflects a domain-general valuation comparison mechanism, which acts to bias participants away from decisions to engage in cognitive effort, when the perceived subjective costs of such engagement outweigh the reward-related benefits. These findings complement work in other cost domains and species by pointing to a clear role of the dACC in representing subjective value differences between choice options during cost-benefit decision-making.

A pandemic-related affect gap in risky decisions for self and others

ABSTRACT The early stages of the COVID-19 pandemic exposed large portions of the global populations to increased daily stressors. Research on risky choice in medical contexts suggests that affect-rich choice options promote less-advantageous decision strategies compared with affect-poor options, causing an “affect gap” in decision making. The current experiments (total N = 437, age range: 21–82) sought to test whether negative pandemic-related affect would lower expected-value (EV) maximisation within individuals. In Experiment 1, participants indicated how much they would be willing to pay to avoid specific pandemic experiences (e.g. “not being able to gather in groups”), and then chose among pairs of risky prospects that involved pandemic experiences or subjectively-equivalent monetary losses. EV maximising was lower for pandemic experiences than for equivalent monetary losses. Experiment 2 replicated this finding, and further demonstrated a moderating role of decision perspective. EV maximising was greater in decisions made for another person than in decisions made for oneself. These findings highlight potential strategies for boosting decision making under affect-rich real-world conditions.

Influence of Cultivar-Dependent Alstroemeria Floral Emissions on Frankliniella occidentalis Host Selection Behavior

Frankliniella occidentalis, commonly known as the western flower thrips (WFT), is one of the world’s most significant cosmopolitan pests. This pest infests many ornamental species, including Alstroemeria, leading to substantial economic losses. F. occidentalis damages flowers, transmits viruses, and causes the rejection of shipments for exports. Farmers have observed variations in the occurrence of F. occidentalis among different Alstroemeria cultivars. It is hypothesized that differences in flower color and odor among cultivars may influence the host-choice behavior of this insect, potentially explaining the observed variations in incidence and damage in the field. To test this hypothesis, we analyzed one year’s worth of sampling data for the occurrence of the WFT complex in a commercial Alstroemeria greenhouse crop. This analysis identified cultivars with high and low thrips incidences. The ‘Himalaya’ and ‘Whistler’ cultivars exhibited the highest incidence, while the ‘Shakira’ and ‘Nora’ cultivars showed the lowest incidence values. To investigate the potential role of host odors in these field incidence differences, we conducted behavioral tests (choice, non-choice, and repellency) using glass boxes where visual stimuli were blocked. These tests confirmed a differential attraction response of thrips to the flowers of Alstroemeria cultivars, although all cultivars were viable options for WFT choice. Preferences under laboratory conditions differed from the incidence observed in the greenhouse, ruling out a repellency effect of some cultivars on insects. This study provides evidence that differential emissions from Alstroemeria flowers can influence host selection by WFT, a phenomenon that warrants further in-depth exploration in future studies.

Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks.

In probabilistic reversal learning, the choice option yielding reward at higher probability switches at a random trial. To perform optimally in this task, one has to accumulate evidence across trials to infer the probability that a reversal has occurred. In this study, we investigated how this reversal probability is represented in cortical neurons by analyzing the neural activity in prefrontal cortex of monkeys and recurrent neural networks trained on the task. We found that neural trajectories encoding reversal probability had substantial dynamics associated with intervening behaviors necessary to perform the task. Furthermore, the neural trajectories were translated systematically in response to whether outcomes were rewarded, and their position in the neural subspace captured information about reward outcomes. These findings suggested that separable dynamic trajectories, instead of fixed points on a line attractor, provided a better description of neural representation of reversal probability. Near the behavioral reversal, in particular, the trajectories shifted monotonically across trials with stable ordering, representing varying estimates of reversal probability around the reversal point. Perturbing the neural trajectory of trained networks biased when the reversal trial occurred, showing the role of reversal probability activity in decision-making. In sum, our study shows that cortical neurons encode reversal probability in a family of dynamic neural trajectories that accommodate flexible behavior while maintaining separability to represent distinct probabilistic values.

Assessing and mitigating transfer gaps through ecosystem interactions

The purpose of this paper is to determine the most appropriate model of cooperation between an enterprise and the innovation ecosystem of the territory based on the assessment of its readiness to implement joint innovation activities. One of the requirements necessary for the effectiveness of innovation activity is to ensure the continuity of innovation processes along the entire value chain. The peculiarities of different organizations and different levels of readiness of ecosystem participants for innovation activities lead to ambiguity in the choice of possible options for partnership interactions. The paper presents a scheme of development for the territory's innovation ecosystem based on the concept of a minimum viable ecosystem. The concept of transfer gap is introduced as a violation of the continuity of the process of transfer (transfer) of the results of innovation activity along the entire value chain, which does not allow to obtain a competitive result (an innovative product) and/or bring it to the consumer within a competitive timeframe. Researchers identify two components of the transfer gap: technological and managerial. We developed indicators and scales for their assessment. On the basis of analyzing the interests and risks of participants in innovation processes in all links of the innovation chain, the possibilities of the innovation ecosystem to dampen transfer gaps are identified. We form the model of overcoming transfer gaps on the basis of partnership interactions.