Method Of Choice Research Articles

An in Vitro Evaluation of the 14-Day Microbial Barrier Property of Exofin High Viscosity Topical Skin Adhesive.

Background: Wound closure is a critical aspect of medical care, and the choice of closure methods plays a pivotal role in preventing infections. Traditional sutures and staples can introduce foreign material into the wound, increasing the risk of infection. Adhesives offer a potential alternative by providing a physical barrier against microorganisms. Objective: To assess the microbial barrier properties of Exofin High Viscosity Topical Skin Adhesive (HVTSA), a novel adhesive system, against a range of challenge organisms. Methods: This study, conducted by the independent research organization NAMSA (North American Science Associates, LLC), aimed to evaluate the effectiveness of Exofin HVTSA as a microbial barrier. This study was carried out by an independent research organization NAMSA. Challenge organisms, including Staphylococcus aureus, Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus brasiliensis, were used to evaluate the adhesive's effectiveness. Inocula of each organism were placed on cured Exofin HVTSA test articles and observed for 14 days. Positive and negative control plates were included to validate the effectiveness of the challenge organisms and assess the absence of contamination. Results: Exofin HVTSA demonstrated effective microbial barrier properties against all challenge organisms, except Pseudomonas aeruginosa. No growth or color change was observed for Staphylococcus aureus, Staphylococcus epidermidis, MRSA, Escherichia coli, Candida albicans, and Aspergillus brasiliensis over the 14-day observation period. Pseudomonas aeruginosa exhibited no growth, but showed a color change in two out of five replicates on day 14. Conclusion: Exofin HVTSA demonstrated effective microbial barrier properties for 14 days against a range of common wound pathogens, suggesting its potential as a safe and effective alternative to traditional wound closure methods. Further research is warranted to investigate its efficacy in clinical settings.

Formation of bovine serum albumin-galangin nanoparticles and their potential to inhibit ROS-induced inflammation: Enthanol desolvation vs. pH-shiftng method

pH-shifting method, as an eco-friendly approach, is a promising alternative to desolvation method, yet systematic comparison of their property is still lacking. In this study, bovine serum albumin-galangin nanoparticles (BSA-GA NPs) were designed for alleviating ROS-mediated macrophage inflammation by the 2 separate methods. Compared with the desolvation method, BSA exhibited a higher loading capacity for GA under the pH-shifting method, which was attributed to the exposure of the binding site leading to enhanced affinity for GA and a more compact particle structure. Further analyses evidenced that the electron arrangement and crystal structure of GA changed with different methods. The content of random coil of BSA was elevated after pH-shifting method. Besides, the smaller size rendered the pH-shifting treated BSA-GA NPs easier to be taken up by macrophages, while the enhanced specific surface area conferred excellent ROS scavenging and anti-inflammatory performances. This study may provide new insights into the choice of loading methods.

Choice of landscape discretisation method affects the inferred rate of spread in wildlife disease spread models

Disease modelling at the livestock-wildlife interface is an important topic for which discrete-space models are used for the wildlife component. One prominent example is African Swine Fever, where wild boar play an influential role as reservoirs of disease spillover into domestic pig farms. In this paper, we present a simulation study that demonstrates the impact of seemingly arbitrary choices of landscape discretisation method on the inferred rate of spread within the model. We use an ordinary differential equation model to implement a simplified model of disease transmission between discrete groups of wild boar with spillover into domestic pig farms contained within a homogeneous landscape. We examine a range of scenarios whereby the landscape is discretised into wild boar patches of varying size and shape, and compare the rate of spread between domestic pig farms placed at fixed points on the landscape. Our results demonstrate a non-monotonic relationship between patch size and rate of spread, which is particularly unstable and unpredictable for square and triangular shaped patches. Discretisation of the landscape into hexagons appears to produce a more stable relationship between patch size and rate of spread for the three types of transmission kernel we investigated. Although the rate of disease spread does converge to a stable value, this occurs at patch sizes that are much smaller than would be used in practice for wild boar. We conclude that outputs of disease models containing a wildlife component should not be considered to be robust to arbitrary choices for patch size and placement, but rather as a source of uncertainty to be examined using sensitivity analysis. Furthermore, we strongly recommend the use of hexagons rather than squares or right triangles for landscape discretisation.

High-throughput and high-sensitivity biomarker monitoring in body fluid by fast LC SureQuant™ IS targeted quantitation

Targeted proteomics methods have been greatly improved and refined over the last decade and are becoming increasingly the method of choice in protein and peptide quantitative assays. Despite the tremendous progress, targeted proteomics assays still suffer from inadequate sensitivity for lower abundant proteins and throughput, especially in complex biological samples. These attributes are essential for establishing targeted proteomics methods at the forefront of clinical use. Here, we report an assay utilizing the SureQuantTM internal standard triggered targeted method on a latest generation mass spectrometer coupled with an EvoSep One liquid chromatography platform, which displays high sensitivity and a high throughput of 100 samples per day (SPD). We demonstrate the robustness of this method by quantifying proteins spanning six orders of magnitude in human wound fluid exudates, a biological fluid that exhibits sample complexity and composition similar to plasma. Among the targets quantified were low-abundance proteins such at tumor necrosis factor A (TNFA) and interleukin 1-β (IL1B), highlighting the value of this method in the quantification of trace amounts of invaluable biomarkers that were until recently hardly accessible by targeted proteomics methods. Taken together, this method extends the toolkit of targeted proteomics assays and will help to drive forward mass spectrometry-based proteomics biomarker quantification.

Congenital trans-mesentric internal hernia: a rare cause of acute intestinal obstruction in adult

Introduction and Importance: Internal hernia is responsible for 0.6–5.8% of all small intestinal obstructions. Only 8% of internal hernias are of the congenital trans mesenteric variant. Urgent surgical intervention should be considered in individuals who exhibit intestinal obstruction before the development of irreversible bowel ischemia and necrosis. Case Presentation: The authors report a 38-year-old male patient who presented to the emergency department with abdominal pain, distension, and vomiting for the last three days. After an explorative laparotomy, it was confirmed that there was a trans mesenteric hernia defect with strangulated distal ileal loops. End-to-end ileo-ileal anastomosis was done. Clinical Discussion: Early recognition and subsequent surgical treatment permit proper management and prevent complications. There should be a differential diagnosis. In this case, there is no prior history of abdominal surgery, and the patient presents with recurrent abdominal pain and intestinal obstruction. Conclusion: Early diagnosis and emergency laparotomy can save the intestine before gangrene, lowering morbidity and mortality, correcting the mesenteric defect to prevent recurrences, and enhancing clinical outcomes because many studies have shown that some cases are missed before radiological investigation. Laparotomy is still the method of choice for acute cases of incarceration with bowel obstruction, strangulation, and ischemia. The entire mesentery needs to be evaluated, and all mesenteric defects need to be sutured to prevent recurrence.

Cytogenetic spectrum and clinical presentation of Klinefelter syndrome: A comprehensive study from South India

BackgroundKlinefelter syndrome (KS) is a common sex chromosome abnormality that mostly presents as testicular failure and a myriad of other clinical features. The phenotypic features and their severity vary between individuals, age groups and cytogenetic subtypes. Karyotyping remains the method of choice for the diagnosis of KS despite advanced molecular testing in this modern era. The objective of this study was to determine the cytogenetic subtypes, clinical presentation and hormonal profile of patients with KS. MethodsRetrospective observational study comprised patients with KS determined by cytogenetic analysis at the tertiary care centre in south India from 2001 to 2019. Clinical details including testicular size, hormone levels and semen analysis were obtained from the medical records. ResultsThere were 147 KS (145 post-natal and 2 pre-natal) patients ranging in age from two days to 51 years, 116 (74.8%) patients being ≥18 years. Classic (cKS), mosaic (mKS) and variant KS (vKS) accounted for 126 (85.7%), 9 (6.1%) and 12 (8.2%) cases and their mean ages were 26.6, 29.6 and 12.8 years, respectively. cKS and mKS had diverse clinical presentations including several co-morbidities of which small testes were most common (94.8%). vKS presented with behavioural problems (58.3%) without any comorbidities. Testosterone (p < 0.05), FSH and LH levels were abnormal in >90% of patients. ConclusionAll three cytogenetic subtypes of KS were seen in our patients. cKS was seen in all ages, mKS was common in adults and vKS was seen predominantly in children. Early diagnosis of KS and timely medical intervention may alter the clinical outcomes and improve the quality of life.

Factors Affecting The Choice of Core Earnings Management Tool

Prior studies document that managers manipulate core earnings through different methods to favourably influence the perception of stakeholders towards the operating performance of the firm. However, it is of interest to examine which core earnings manipulation method is preferred by firms because each method needs a different set of opportunities and incentives. The current study explores the methods of core earnings manipulation, namely expense misclassification and revenue misclassification in terms of opportunities and incentives. Results show that the choice of method largely depends on the size and age of the firm. In particular, results exhibit that large and old firms prefer revenue misclassification over expense misclassification for managing core earnings. This effect is found to be more pronounced among large older firms. Our subsequent tests suggest that Big Four auditors (Deloitte, Ernst &amp; Young, KPMG, and PricewaterhouseCoopers) have a constraining effect on expense misclassification, however, they are unable to mitigate the corporate misfeasance of revenue misclassification, implying the partial effectiveness of Big Four auditors in curbing classification shifting. These results are robust to the alternative measurement of misclassification practices and endogeneity issues. The findings have important implications for auditors, analysts, and accounting standard-setters.

DEVELOPMENT OF HIGHLY EFFECTIVE MILLING CHISEL PLOUGHWITH SIMULTANEOUS LOCAL APPLICATION OF HYDROGEL

The given article is related to agricultural engineering and the design of milling chisel ploughwith special working bodies for cutting water-absorbing slots with simultaneous introduction of hydrogel mixture into them was developed to increase moisture accumulation in soil in the article. Improved technologies and techniques are needed to improve the quality and quantity of crops, in particular cereals, in order to improve their production. Most of the territory of Kazakhstan belongs to the zone of risky agriculture. Every year there are droughts that significantly reduce cereal yields. Many farmers are making large amounts of fertilizer in order to increase yields. However, there is the problem of unsustainable use of fertilizers. Thus, most of fertilizers introduced into soil is washed into its lower layers and becomes inaccessible to plant roots. Therefore, we propose to use local application of hydrogel retention mixture to accumulate nutrients and soil moisture. Its granules are able to absorb liquid, in volume many times larger than their own, and hold it for a long time. For better nutrition of plants, we offer to enrich hydrogel with fertilizers. Possible machines for application of hydrogel mixture are considered in «Analysis of possible methods of application of hydrogel with fertilizers in soil». It is noted that there are no units capable of carrying out local application of granules with fertilizers together with milling chisel ploughinto seeding area in the modern system of machines. Existing machines allow the application of hydrogel in dispersed or subsoil way, and local application of granules together with fertilizers is used for the first time and allows place hydrogel with saturated fertilizers. The choice of optimal method of application of hydrogel mixture pellet was produced and the machine design for its implementation was developed on the basis of common and private methods. Keywords:milling chisel plough, working body, design, hydrogel, moisture, soil, technology.

Assessment of economic efficiency of artificial intelligence application in construction: the choice of the optimal method

Assessment of economic efficiency of artificial intelligence application in construction: the choice of the optimal method

Quantum refinement in real and reciprocal space using the Phenix and ORCA software.

X-ray and neutron crystallography, as well as cryogenic electron microscopy (cryo-EM), are the most common methods to obtain atomic structures of biological macromolecules. A feature they all have in common is that, at typical resolutions, the experimental data need to be supplemented by empirical restraints, ensuring that the final structure is chemically reasonable. The restraints are accurate for amino acids and nucleic acids, but often less accurate for substrates, inhibitors, small-molecule ligands and metal sites, for which experimental data are scarce or empirical potentials are harder to formulate. This can be solved using quantum mechanical calculations for a small but interesting part of the structure. Such an approach, called quantum refinement, has been shown to improve structures locally, allow the determination of the protonation and oxidation states of ligands and metals, and discriminate between different interpretations of the structure. Here, we present a new implementation of quantum refinement interfacing the widely used structure-refinement software Phenix and the freely available quantum mechanical software ORCA. Through application to manganese superoxide dismutase and V- and Fe-nitrogenase, we show that the approach works effectively for X-ray and neutron crystal structures, that old results can be reproduced and structural discrimination can be performed. We discuss how the weight factor between the experimental data and the empirical restraints should be selected and how quantum mechanical quality measures such as strain energies should be calculated. We also present an application of quantum refinement to cryo-EM data for particulate methane monooxygenase and show that this may be the method of choice for metal sites in such structures because no accurate empirical restraints are currently available for metals.

COMPREHENSIVE ASSESSMENT OF TREATMENT SATISFACTION WITH COMPLETE DENTURES ARTICULATED WITH THE T-SCAN SYSTEM AND ARTICULATION PAPER

Background: Prosthetic treatment in case of complete edentulism has the task of restoring the lost chewing function, speech and breathing and preventing the appearance or deepening of the reduction changes of both the soft tissues and the bones in the maxillofacial region, as well as restoring the aesthetic appearance and improving the psyche of the patient The aim of the present pilot study is to evaluate the satisfaction with treatment with complete dentures articulated with articulation paper and the T-SCAN system, which will serve as the basis for a large-scale cross-sectional study. Material and methods: The study includes a sample of 20 completely edentulous patients. The sample consisted of 10 women and 10 men. The studied patients were randomly divided into two groups of 10 people each. The patients were interviewed post treatment [at 5 weeks], a validated questionnaire about oral health-related quality of life in edentulous people [OHIP-EDENT] was applied. Results: The digital occlusal analysis provides more accurate information on the articulation of the prostheses, as it indicates the teeth with increased force in percentages and also the sequence of occurrence of the occlusal contacts. Analysis of occlusal contacts is subjective, and articulating them with this method carries error risks.When using the T-Scan system, patients are more satisfied than the treatment with total patients, as they feel the prostheses are much more comfortable and in much fewer visits. Conclusion: This quantitative methodology can be used as the method of choice for control of occluso-articulation relationships in treatment with total dentures in any dental practice, if technically possible

On the estimation of population size-A comparison of capture-recapture and multiplier-benchmark methods.

Approaches to population size estimation are of importance across a wide spectrum of disciplines, especially when census and simple random sampling are impractical. The capture-recapture method and the multiplier-benchmark method are two commonly used approaches that use data that partially capture the target population and overlap in a known way. Due to similarities in required data structures, the approaches are often used interchangeably without a critical appraisal of the underlying assumptions, especially in the two-sample case. Here, we describe the similarities and differences of the sampling mechanisms and assumptions underlying both approaches. We emphasize that the capture-recapture method assumes data sources as random samples and describes two-way inclusion histories, while in multiplier-benchmark method, one source captures a fixed sub-population, and the one-way inclusion histories are modeled. We also discuss the implications of these differences through simulation and real data to guide the choice of method in practice. A careful study of the data structures, relationships, and data generation processes is crucial for assessing the appropriateness of using these methods.

Clinical breast examination: A screening tool for lower- and middle-income countries.

Breast cancer (BC) remains a global health challenge, devastatingly impacting women's lives. Low-and-middle-income countries (LMIC), such as India, experience a concerning upward trend in BC incidence, necessitating the implementation of cost-effective screening methods. While mammography, ultrasonography, and magnetic resonance imaging are preferred screening modalities in resource-rich settings, limited resources in LMICs make clinical breast examination (CBE) the method of choice. This review explores the merits of CBE, its coverage, barriers, and facilitators in the Indian context for developing strategies in resource-constrained settings. CBE has shown significant down-staging and cost-effectiveness. Performed by trained health workers in minutes, CBE offers an opportunity for education about BC. Various individual and health system barriers, such as stigma, financial constraints, and the absence of opportunistic screening hinder CBE coverage. Promising facilitators include awareness programs, capacity building, and integrating CBE through universal health care. No healthcare provider must miss any screening opportunity through CBE.

Associations of the implementation of the three-child policy with changes in contraceptive methods among women who underwent induced abortion: a cross-sectional study of Wuhan, a megacity in central China

Background Induced abortion, as a legal medical practice in China, has an enormous negative impact on women’s sexual and reproductive health. After the implementation of the three-child policy, guiding women to choose appropriate contraceptive measures to protect their fertility is the focus of China’s family planning. But little is known about the impact of the family planning policy on women’s contraceptive behaviour. Methods We collected 7022 cases who underwent abortion between July 2020 and June 2022 in Wuhan. Based on the time of implementation of the policy, the study population was divided into two groups, namely, the pre-policy group (before July 2021, Group 1) and the post-policy group (after July 2021, Group 2). Logistic regression was used to analyse the effect of the policy on women’s choice of different contraceptive methods for abortion. Results There were a total of 3487 cases in Group 1, accounting for 49.65%, and 3535 cases in Group 2, accounting for 50.34%. The proportion of women choosing efficient contraceptive methods after the Three-Child Policy decreased compared with before. A correlation was observed between the implementation of the Three-Child Policy and whether to choose efficient contraceptive methods after abortion (p < 0.001). Conclusion The study has found that after the Three-Child Policy, women opting for induced abortion tend to prefer less effective contraceptive methods, particularly condoms. There is a marked shift towards more effective contraception methods both before and after the implementation of the Three-Child Policy.

Treatment of post-thalamic hemorrhage hydrocephalus: ventriculoperitoneal shunt or endoscopic third ventriculostomy? A retrospective observational study

BackgroundThe aim of this study was to compare the efficacy of ventriculoperitoneal shunt (VPS) and endoscopic third ventriculostomy (ETV) for the treatment of hydrocephalus after thalamic hemorrhage (TH) where external ventricular drainage (EVD) could not be removed after hematoma absorption, and to provide a theoretical basis for the clinical treatment of hydrocephalus after TH.MethodsThe clinical data of patients with hydrocephalus after TH whose EVD could not be removed after hematoma absorption were retrospectively analyzed. According to the patients’ surgical methods, the patients were divided into the VPS group and ETV group. The operative time, length of hospital stay, complications, and reoperation rates of the two groups were compared.ResultsThere was no statistically significant difference in intraoperative bleeding, length of hospital stay between the two groups. The EVD tubes were successfully removed in all patients after surgery. There were 4 (9.5%) complications in the ETV group and 3 (6.7%) complications in the VPS group, with no statistically significant difference in postoperative complications between the two groups. During the 1-year follow-up, 7 patients (16.7%) in the ETV group and 3 patients (6.7%) in the VPS group required reoperation. In the subgroup analysis of TH combined with fourth ventricular hemorrhage, 6 patients (14.3%) in the ETV group and 1 patient (2.2%) in the VPS group required reoperation, and the difference between the two groups was statistically significant.ConclusionsETV had good efficacy in treating hydrocephalus caused by TH and TH that broke into the lateral ventricle and the third ventricle. However, if hydrocephalus was caused by TH with the fourth ventricular hematoma, VPS was a better surgical method because the recurrence rate of hydrocephalus in ETV was higher than that in VPS. Therefore, the choice of surgical method should be based on the patient’s clinical features and hematoma location.

Comparison of Biomechanical, Clinical Indicators, and Quality of Life in People Undergoing Hip Replacement Surgery with Anterior and Posterior Approaches

Background: There are ongoing debates among surgeons regarding the most effective surgical method for hip replacement, with varying preferences for the anterior and posterior approaches. Both methods have demonstrated excellent long-term outcomes, with clinical differences primarily observed in the early postoperative period. Objectives: This study aimed to compare the anterior and posterior methods of hip replacement after six months of surgery in terms of biomechanical and clinical indicators, as well as quality of life. Methods: In this cross-sectional observational study, 42 patients who underwent hip replacement surgery using either the anterior (n = 22) or posterior method (n = 20) at least six months (and a maximum of 12 months) post-surgery, along with 20 healthy individuals, were evaluated. Biomechanical indices of the center of pressure (COP) were measured using a force plate during two-leg standing with eyes open and closed. Functional balance, independence, self-perception of performance, satisfaction, and quality of life were assessed using the timed up and go test (TUG), Barthel Index, Canadian Occupational Performance Measure (COPM), and the SF-36, respectively. Results: No significant differences were found between the anterior and posterior groups in terms of COP, clinical variables, and quality of life (P &gt; 0.05). However, when compared to the control group, the anterior replacement group exhibited significantly higher COP displacement in the medial-lateral direction (P = 0.03) and COP velocity in the anterior-posterior direction (P = 0.02) during two-leg standing with eyes open. No significant differences in COP variables were observed in the posterior replacement group compared to the control group (P &gt; 0.05). Conclusions: The findings indicate no significant differences between the anterior and posterior approaches to hip replacement in terms of biomechanical and clinical indicators, as well as quality of life after six months. Therefore, the choice of surgical method can be based on the patient's condition and the surgeon’s expertise in the respective approach.

Manajemen Anestesi Pada Pasien Rencana Open Reduction and Internal Fixtation (ORIF) + Post Craniotomy

Surgery is generally the treatment method of choice for these fractures because of the difficulty in maintaining cast reduction or functional bracing. One of the operative treatments is open reduction and internal fixation (ORIF). ORIF is a surgical procedure performed with the aim of restoring bone alignment and providing stability to broken bone fragments after a fracture.

Factors affecting the accuracy of prehospital triage application and prehospital scene time in simulated mass casualty incidents

BackgroundThe contemporary management of mass casualty incidents (MCIs) relies on the effective application of predetermined, dedicated response plans based on current best evidence. Currently, there is limited evidence regarding the factors influencing the accuracy of first responders (FRs) in applying the START protocol and the associated prehospital times during the response to MCIs. The objective of this study was to investigate factors affecting FRs’ accuracy in performing prehospital triage in a series of simulated mass casualty exercises. Secondly, we assessed factors affecting triage-to-scene exit time in the same series of exercises.MethodsThis retrospective study focused on simulated casualties in a series of simulated MCIs Full Scale Exercises. START triage was the triage method of choice. For each Full-Scale Exercise (FSEx), collected data included exercise and casualty-related information, simulated casualty vital parameters, simulated casualty anatomic lesions, scenario management times, and responder experience.ResultsAmong the 1090 casualties included in the primary analysis, 912 (83.6%) were correctly triaged, 137 (12.6%) were overtriaged, and 41 (3.7%) were undertriaged. The multinomial regression model indicated that increasing heart rate (RRR = 1.012, p = 0.008), H-AIS (RRR = 1.532, p < 0.001), and thorax AIS (T-AIS) (RRR = 1.344, p = 0.007), and lower ISS (RRR = 0.957, p = 0.042) were independently associated with overtriage. Undertriage was significantly associated with increasing systolic blood pressure (RRR = 1.013, p = 0.005), AVPU class (RRR = 3.104 per class increase), and A-AIS (RRR = 1.290, p = 0.035). The model investigating the factors associated with triage-to-scene departure time showed that the assigned prehospital triage code red (TR = 0.841, p = 0.002), expert providers (TR = 0.909, p = 0.015), and higher peripheral oxygen saturation (TR = 0.998, p < 0.001) were associated with a reduction in triage-to-scene departure time. Conversely, increasing ISS was associated with a longer triage-to-scene departure time (TR = 1.004, 0.017).ConclusionsUnderstanding the predictors influencing triage and scene management decision-making by healthcare professionals responding to a mass casualty may facilitate the development of tailored training pathways regarding mass casualty triage and scene management.

Blunt force trauma in forensic radiology

Description of the main forensic radiological examination modalities and findings in blunt force trauma in living and deceased adults. Elaboration of the essential points based on the authors' own experiences and relevant literature. Injury-related consequences of blunt force are frequently observed in forensic radiological diagnostics, especially in the context of accidents and suicides, and less frequently in homicides. The method of choice for radiological imaging of blunt force in deceased persons is native postmortem computed tomography (PMCT). In principle, the radiological effects of blunt force in PMCT do not differ significantly from those in living persons. Postmortem magnetic resonance imaging (PMMRI) is very suitable for imaging blunt soft tissue injuries in the shorter postmortem interval. In the case of living individuals with the consequences of blunt force trauma, imaging is primarily indicated for clinical diagnostic reasons. Common indications are domestic violence, violence against the elderly, and disputes in public spaces. The choice of radiological examination method depends on the clinical history and symptoms, and the radiological examinations can be subjected to aforensic assessment.

Endoscopic interventions in patients with bronchial tumors

Analysis of the results of endoscopic diagnosis and treatment of patients with bronchial tumors. Material and methods. Endoscopic diagnosis and interventions were perfomed in 56 patients with benign - 39 (70.7%) and malignant - 17 (29.3%) bronchial tumors. There were 38 men and 18 women aged from 17 to 70 years (average age of patients 52.1 ± 14.6 years). Results. In patients with benign bronchial tumors, mechanical removal or excision by using polypectomy share was more often performed. In cases malignant tumors (10 patients) stent insertion was performed to ensure long-term maintenance of the bronchial lumen. In two cases - silicone stents were inserted; in eight cases - metal self-expanding stents were inserted. There were no complications during the intervention or in the postoperative period. Repeated interventions due to tumor recurrence were performed in 3 (5.4%) patients. Conclusion. Endoscopic interventions in patients with benign and malignant bronchial tumors can effectively and relatively safely restore and maintain airway patency. The choice of tumor removal method is multifactorial. It depends on the equipment of the medical institution and the endoscopist preference. To maintain bronchial patency in patients with malignant bronchial tumors, stenting is indicated, which avoids staged endoscopic interventions, each of which can be potentially dangerous due to possible complications.