Introduction: The long-term results of pancreatic tumors resections are disappointing. In order to increase postoperative survival after resections by surgical control of liver metastasis and peritoneal dissemination no-touch techniques of PD were proposed. Methods: We investigated the results of no-touch PD for malignant periampullary tumors in 31 patients, treated in our clinic in the period of November 20082011 years. In 14 patients tumors of papilla of Vater (PV) were diagnosed, in 12 tumors of the pancreas, 1neuroendocrine tumor, in 3 patientstumors of bile ducts (BD), 1 – gastrointestinal stromal tumor (GIST) of the duodenum. In 19 patients pylorus-preserving PD were done, in 12standard PD. In 3 patients additional resections of the affected portal or superior mesenteric vein were done. Results: Duration of the operation was 440,4 +77,4 minutes (from 340 to 745). Mean blood loss was 575,0 + 320,1 ml (from minimal to 1800). Morbidity was 22,6% (7 patients). Mortality was zero. Median survival in the group of BD cancer patients was 21,5 month. 1and 2year survival in pancreatic cancer patients was 63,5%, maximal follow-up26 months. 1and 2year survival for PV cancer patients was 100%, 3year survival85,7%, disease free 3-year survival57,1%. Patient with GIST is alive 34 months after procedure with metastatic disease from second postoperative year. Patient with neuroendocrine tumor is alive without metastatic disease 26 months after operation. Conclusion: No-touch PD is safe procedure. Further investigations should be done to evaluate potential benefit of the procedure.