CHO Mouth Rinse Research Articles

Impact of a Carbohydrate Mouth Rinse on Motor Performance and Corticospinal Motor Excitability

Application of a carbohydrate (CHO) mouth rinse (MR) prior to exercise has been shown to improve physical performance and facilitate corticospinal motor excitability. It is unclear if different forms of CHO impact this phenomenon. PURPOSE: The purpose of this investigation is to determine the effects of different forms of a CHO MR on muscular performance and corticospinal motor excitability. METHODS: Ten normal healthy subjects (5 females, 5 males; 25±1 years; 1.71±0.03 m 73±5 kg) completed 4 trials each separated by at least 48 hours. A different MR condition was applied during each trial (Placebo (PLAC), 6.4% glucose (GLU), 6.4% maltose (MAL), 6.4% maltodextrin (MDX)). Maximal voluntary contraction (MVC) of the right knee extensors and motor-evoked potential (MEP) of the right vastus medialis was determined pre (10 min before), immediately after, and post (10 min after) application of the MR. MEP was precipitated by applying transcranial magnetic stimulation (TMS) during muscle contraction (50% of MVC). The MR was held in the mouth for 20 sec and MR treatments were applied using a Latin square design. RESULTS: No differences were found in the change of MEP from pre to immediately after the MW across the conditions (PLAC=1.5±4.4%; GLU=-6.2±11.2%; MAL=3.9±3.4%; MDX=8.9±7.9%). In contrast, the increase in MEP was greater at the post time point in CHO conditions (GLU=-11.3±14.7%, p=0.01; MAL=12.9±7.9%, p=0.07; MDX=28.0±14.4%, p=0.02) as compared to PLAC (PLAC=-14.3±7.8%). MVC was similar at pre (PLAC=260±26 Nm; GLU=241±19 Nm MAL=245±21 Nm; MDX=248±25 Nm), after (PLAC=269±26 Nm; GLU=249±18 Nm MAL=257±19 Nm; MDX=250±23 Nm), and 10 min after (PLAC=262±28 Nm; GLU=256±17 Nm MAL=269±25 Nm; MDX=253±21 Nm) the MW. CONCLUSIONS: CHO MR increased corticospinal motor excitability 10 min after application; however, the form of CHO used did not influence this response. The increase in corticospinal motor excitability did not translate into an improvement in motor performance.

Carbohydrate Mouth Rinse Fails to Improve Four-Kilometer Cycling Time Trial Performance

We investigated if a carbohydrate (CHO) mouth rinse may attenuate global fatigue and improve 4-km cycling time trial (TT4km) performance. After a preliminary session, cyclists (n = 9) performed a TT4km after a CHO or placebo (PLA) mouth rinse. Mean power output, time, and ratings of perceived exertion (RPE) were recorded throughout the TT4km. Twitch interpolation responses (%VA; voluntary activation and ∆Tw; delta peak twitch torque) were compared pre and post TT4km with traditional statistics and effect size (ES) analysis. Time-to-complete the 4 km and mean power output were comparable between CHO (386.4 ± 28.0 s) and PLA (385.4 ± 22.4 s). A lower central (p = 0.054) and peripheral (p = 0.02) fatigue in CHO than in PLA were suggested by an extremely-large ES in %VA (manipulation main effect: p = 0.052, d = 1.18; manipulation-by-time interaction effect: p = 0.08, d = 1.00) and an extremely, very-large ES in ∆Tw (manipulation main effect: p = 0.07, d = 0.97; time-by-manipulation interaction effect: p = 0.09, d = 0.89). The RPE increased slower in CHO than in PLA (p = 0.051; d = 0.7). The apparent reduction in global fatigue (central and peripheral) and RPESLOPE with only one CHO mouth rinse were not translated into improved TT4km performance. Further tests may be required to verify if these likely differences in global fatigue might represent an edge in the short-lasting cycling time trial performance.

Carbohydrate mouth rinse reduces rating of perceived exertion but does not affect performance and energy systems contribution during a high-intensity exercise

ABSTRACT Aim The study aimed to verify the effect of carbohydrate (CHO) mouth rinse on time to exhaustion, energy systems contribution and rating of perceived exertion (RPE) during a high-intensity exercise. Methods Fourteen men performed an incremental exercise test to determine their maximal oxygen uptake and peak power output (PPO) and two time-to-exhaustion tests at 110% of PPO. Participants rinsed their mouth with 25ml of 6.4% of CHO or placebo (PLA) solution immediately before the time-to-exhaustion test, using a crossover design. The contribution of the energy systems was calculated using the free software GEDAE-LaB®. Results Time to exhaustion was similar between the conditions (CHO:174.3±42.8s; PLA:166.7±26.3s; p=0.33). In addition, there was no difference between the CHO and PLA condition for aerobic (CHO:135.1±41.2kJ and PLA:129.8±35.3kJ, p=0.34), anaerobic lactic (CHO:57.6±17.1kJ and PLA:53.4±15.1kJ, p=0.10), and anaerobic alactic (CHO:10.4±8.4kJ and PLA:13.2±9.2kJ, p=0.37) contribution. Consequently, total energy expenditure was similar between conditions (CHO:203.2±46.4kJ and PLA:196.5±45.2kJ, p=0.15). However, CHO mouth rinse reduced the RPE at the moment of exhaustion (CHO:18.2±1.0units and PLA:19.1±1.1units; p=0.02). Conclusion CHO mouth rinse neither increased time to exhaustion nor altered energy systems contribution during a high-intensity exercise, but reduced the perceived effort at the exhaustion.

Effect of carbohydrate mouth rinse on exercise performance in horses

The mechanism related to the practice of oral carbohydrate (CHO) supplementation prior to intense exercise of a short duration (<30 min) for athletic horses remains unclear. Several studies in human athletes showed that the central nervous system played an important role in the enhancement of athletic performance due to CHO contact with undefined receptors in the oropharyngeal mucosa. This study aims to investigate the influence of CHO mouth rinse on the exercise performance of horses. In this double blind, randomised, placebo-controlled study, seven Mangalarga Marchador horses underwent a standardised exercise test (SET) in a field. The following protocols involving a single mouthwash (1 litre) had been used: a mouth rinse of 6.4% maltodextrin-water solution (CHO test), and a mouth rinse of only water solution (placebo test). The mean plasma lactate concentration immediately after SET (lactate peak) was higher in the CHO test (24.33±3.72 mmol/l) than in the placebo test (18.19±4.01 mmol/l), (P<0.001). No difference was observed in the mean time-to-exhaustion, mean and maximum heart rate, plasma glucose concentration and serum creatinine-kinase activity. Several studies described that there were improvements in the time-trial performance of cyclists and runners after a mouth rinse of CHO solution, whereas some did not. Carbohydrate mouth rinse had no influence on exercise performance in this study. Further investigations are required, as the significance of an increased plasma lactate concentration due to a CHO mouth rinse has yet to be elucidated.

Cognitive Performance Enhancement Induced by Caffeine, Carbohydrate and Guarana Mouth Rinsing during Submaximal Exercise.

The aim of this study was to investigate the influence of serial mouth rinsing (MR) with nutritional supplements on cognitive performance (i.e., cognitive control and time perception) during a 40-min submaximal exercise. Twenty-four participants completed 4 counterbalanced experimental sessions, during which they performed MR with either placebo (PL), carbohydrate (CHO: 1.6 g/25 mL), guarana complex (GUAc: 0.4 g/25 mL) or caffeine (CAF: 67 mg/25 mL) before and twice during exercise. The present study provided some important new insights regarding the specific changes in cognitive performance induced by nutritional supplements. The main results were: (1) CHO, CAF and GUA MR likely led participants to improve temporal performance; (2) CAF MR likely improved cognitive control; and (3) CHO MR led to a likely decrease in subjective perception of effort at the end of the exercise compared to PL, GUA and CAF. Moreover, results have shown that performing 40-min submaximal exercise enhances information processing in terms of both speed and accuracy, improves temporal performance and does not alter cognitive control. The present study opens up new perspectives regarding the use of MR to optimize cognitive performance during physical exercise.

Effect of a Carbohydrate Mouth Rinse on Plasma Glucose and Plasma Insulin during a 40‐km Cycling Time Trial

Rinsing the mouth with a carbohydrate solution, without ingesting, improves exercise performance of up to an hour in duration. Performance gains are attributed to the activation of brain regions associated with motivation and motor control. In addition to this neural response, a hormonal cascade may also be present, and include a cephalic‐phase insulin response from oral carbohydrate recognition.PURPOSEThe aim of this study was to examine whether exercise performance gains achieved through a carbohydrate mouth rinse are the partial result of a cephalic‐phase insulin response from oral carbohydrate recognition.METHODSEight trained, competitive cyclists [age (mean ± SEM) = 24 ± 2 y; VO2max = 64.5 ± 2.8 ml/kg/min] completed three simulated, 40‐km time trials comprised of a familiarization trial, carbohydrate mouth rinse trial (CHO) and placebo trial (PLA). Mouth rinse was administered prior to onset of exercise, and every 5‐km throughout exercise. During CHO and PLA trials, plasma glucose and plasma insulin samples were obtained immediately prior to mouth rinsing procedures. Metabolic data and cycling time were collected throughout the exercise session. CHO oxidation rates were calculated based on the equation: g/min = 4.210 VCO2 – 2.962 VO2, while fat oxidation rates were calculated based on: (g/min) = 1.695 VO2 – 1.701 VCO2 (Jeukendrup 2005).RESULTSTime to completion was faster for CHO (67.1 ± 1.1 sec) compared to PLA (67.9 ± 1.0 sec). Plasma glucose did not differ between conditions (p = 0.801) and held steady throughout exercise; additionally, respiratory exchange ratio was not statistically different between conditions (p = 0.081). There was no change in plasma insulin either within trials or between trials (p = 0.638). CHO oxidation rates were not statistically different (p = 0.06) between the CHO (3.43 ± 0.80 g/min) and PLA (2.98 ± 0.18 g/min) groups; fat oxidation rates were not statistically different (p = 0.10) between the CHO (0.59 ± 0.09) and PLA (0.76 ± 0.06) groups.CONCLUSIONSRinsing the mouth with a carbohydrate solution prior to exercise and after each 5‐km interval improved 40‐km time trial performance. This finding shows that improved exercise performance occurs independent of changes in plasma glucose, plasma insulin, RER, or substrate oxidation rates. These findings build on previous research to support the notion of a CHO mouth rinse having primarily a neurological response (Chambers 2009), and not acting via a cephalic‐phase insulin response, in order to improve exercise performance.Support or Funding InformationIndiana University – School of Public Health Student Research Grant Award ‐ March 2016 ($1000)BK Betty Stevens Award (UF funding for trip to Experimental Biology 2017)

Effect of mouth rinsing and ingestion of carbohydrate solutions on mood and perceptual responses during exercise

BackgroundThe aim of this study was to investigate whether mouth rinsing or ingesting carbohydrate (CHO) solutions impact on perceptual responses during exercise.MethodsNine moderately trained male cyclists underwent a 90-min glycogen-reducing exercise, and consumed a low CHO meal, prior to completing an overnight fast. A 1-h cycle time trial was performed the following morning. Four trials, each separated by 7 days, were conducted in a randomized, counterbalanced study design: 15% CHO mouth rinse (CHOR), 7.5% CHO ingestion (CHOI), placebo mouth rinse (PLAR) and placebo ingestion (PLAI). Solution volumes (1.5 ml · kg−1 ingestion trials and 0.33 ml · kg−1 rinsing trials) were provided after every 12.5% of completed exercise. Perceptual scales were used to assess affective valence (feeling scale, FS), arousal (felt arousal scale, FAS), exertion (ratings of perceived exertion, RPE) and mood (profile of mood states, POMS) before, during and immediately after exercise.ResultsThere was no difference in RPE (CHOI, 14.0 ± 1.9; CHOR, 14.2 ± 1.7; PLAI, 14.6 ± 1.8; PLAR, 14.6 ± 2.0; P = 0.35), FS (CHOI, 0.0 ± 1.7; CHOR, −0.2 ± 1.5; PLAI, −0.8 ± 1.4; PLAR, −0.8 ± 1.6; P = 0.15), or FAS (CHOI, 3.6 ± 1.1; CHOR, 3.5 ± 1.0; PLAI, 3.4 ± 1.4; PLAR, 3.3 ± 1.3; P = 0.725) scores between trials. While overall POMS score did not appear to differ between trials, the ‘vigour’ subscale indicated that CHOI may facilitate the maintenance of ‘vigour’ scores over time, in comparison to the steady decline witnessed in other trials (P = 0.04). There was no difference in time trial performance between trials (CHOI, 65.3 ± 4.8 min; CHOR, 68.4 ± 3.9 min; PLAI, 68.7 ± 5.3 min; PLAR, 68.3 ± 5.2 min; P = 0.21) but power output was higher in CHOI (231.0 ± 33.2 W) relative to other trials (221–223.6 W; P < 0.01).ConclusionsIn a CHO-reduced state, mouth rinsing with a CHO solution did not impact on perceptual responses during high-intensity exercise in trained cyclists and triathletes. On the other hand CHO ingestion improved perceived ratings of vigour and increased power output during exercise.

Carbohydrate Mouth Rinsing: Improved Neuromuscular Performance During Isokinetic Fatiguing Exercise.

To determine whether repeated carbohydrate (CHO) mouth rinsing would improve neuromuscular performance during high-intensity fatiguing contractions. Eighteen young men (age 26.1 ± 5.0 y, BMI 22.9 ± 1.9) performed 3 maximal voluntary isometric contractions (MVICPRE). Immediately after, they completed 10-second mouth rinse with 6.4% maltodextrin solution (MAL), 7.1% glucose solution (GLU), water (W), artificially sweetened solution (PLA), or a control trial with no rinse (CON) in a crossover protocol. Subjects performed 5 sets of 30 isokinetic fatiguing contractions at 180°/s, and an MVICPOST with their elbow flexors was performed after each mouth rinse. Mechanical and electromyographic (EMG) signals were recorded from the biceps brachii and parameters of interest analyzed. When rinsing the mouth with a solution containing CHO, independently of the sweetness, isokinetic performance was enhanced as shown by the greater total work achieved in comparison with CON. The decay of torque and mean fiber-conduction velocity (MFCV) recorded at the end of the fatiguing task was lower when rinsing the mouth with GLU than with CON. The torque recorded during the MVICPOST was greater with CHO with respect to CON, and this was associated to a lower decay of MFCV. CHO mouth rinse counteracts fatigue-induced decline in neuromuscular performance, supporting the notion that CHO rinse may activate positive afferent signals able to modify motor output. Repeated mouth rinsing with sweet and nonsweet CHO-containing solutions can improve neuromuscular performance during an isokinetic intermittent fatiguing task.

The Effect of a Carbohydrate Mouth Rinse on Upper-Body Muscular Strength and Endurance.

Dunkin, JE and Phillips, SM. The effect of a carbohydrate mouth rinse on upper-body muscular strength and endurance. J Strength Cond Res 31(7): 1948-1953, 2017-Carbohydrate (CHO) mouth rinsing rapidly increases corticomotor output and maximal muscle force production, which could enhance muscular strength and endurance during resistance exercise. However, previous research has found no effect of CHO rinsing on muscular strength or endurance. The current study altered the CHO rinse composition and frequency and the muscular endurance test to further investigate the effects of a CHO mouth rinse on upper-body muscular strength and endurance. Twelve recreationally resistance-trained men (mean ± SD age 22 ± 1 year, height 179.2 ± 1.8 cm, body mass 80.9 ± 6.1 kg) completed a bench press protocol (1 repetition maximum [RM] test followed by repetitions to failure at 40% of 1RM) on 3 occasions. Subjects rinsed 25 ml of an 18% CHO solution or a placebo for 10 seconds before 1RM and repetitions to failure and completed a no-rinse control condition. Felt arousal (FA) was measured before and after each rinse, heart rate (HR) was measured before and after both exercise protocols, and rating of perceived exertion (RPE) was recorded after repetitions to failure. Rinsing did not influence 1RM (p = 0.680, (Equation is included in full-text article.)= 0.03), repetitions to failure (p = 0.677, (Equation is included in full-text article.)= 0.04), or exercise volume (load × reps; p = 0.600, (Equation is included in full-text article.)= 0.05). There were no significant treatment effects on heart rate (p = 0.677, (Equation is included in full-text article.)= 0.04), FA (p = 0.674, (Equation is included in full-text article.)= 0.04) or rating of perceived exertion (p = 0.604, (Equation is included in full-text article.)= 0.05). A CHO mouth rinse does not improve upper-body muscular strength or endurance.

CHO Mouth Rinse Ameliorates Neuromuscular Response with Lower Endogenous CHO Stores.

This study aimed to investigate carbohydrate (CHO) mouth rinse response on neuromuscular activity, fuel oxidation rates, and cycling performance with different initial levels of endogenous CHO availability. In a double-blind, randomized placebo-controlled design, eight males completed six experimental mouth rinse trials: CHO (6.4% maltodextrin) or placebo solution in a fed state (FED), 12-h fasted state (FAST), or a combined exercise-depleted muscle glycogen and 12-h fasted state (DEP). Trials consisted of 30-min cycling at 90% of gas exchange threshold, followed by a 20-km cycling time trial. Plasma lactate, plasma glucose, oxygen uptake, and EMG activity were measured, and CHO and fat oxidation rates were calculated. CHO mouth rinse maintained higher plasma glucose levels as the constant load exercise progressed (P = 0.023). The reduced EMG activity in the DEP condition with the placebo during constant load exercise was ameliorated with CHO mouth rinse (P < 0.01). Furthermore, the power output and the EMG activity throughout the 20-km time trial were reduced in the DEP condition with placebo but were both restored with CHO mouth rinse (P < 0.05). Time trial performance was only improved with CHO in the DEP compared with the corresponding placebo (P < 0.05), and no differences between supplements were observed in the FED or FAST states. Analyses of the qualitative inference showed "benefit very likely" of CHO mouth rinse on exercise performance in DEP, "possibly benefit" in FAST, and "negligible or trivial" in FED. CHO mouth rinse had no effect on CHO and fat oxidation rates in either exercise mode. The CHO mouth rinse influences exercise performance when endogenous CHO availability is low, and an enhanced central motor drive is potentially the main influencing mechanism.

Carbohydrate mouth rinsing has no effect on power output during cycling in a glycogen-reduced state.

BackgroundThe effect of mouth rinsing with a carbohydrate (CHO) solution on exercise performance is inconclusive with no benefits observed in the fed state. This study examined the effect of CHO mouth rinse or CHO ingestion on performance in 9 moderately trained male cyclists.MethodsFour trials were undertaken, separated by 7 days, in a randomized, counterbalanced design. Each trial included a 90-min glycogen-reducing exercise protocol, immediately followed by a low CHO meal and subsequent overnight fast; the following morning a 1-h cycling time trial was conducted. The trials included 15 % CHO mouth rinse (CHOR), 7.5 % CHO ingestion (CHOI), placebo mouth rinse and placebo ingestion. Solutions were provided after every 12.5 % of completed exercise: 1.5 mL · kg−1 and 0.33 mL · kg−1 body mass during ingestion and rinse trials, respectively. During rinse trials participants swirled the solution for 8 s before expectorating. Blood samples were taken at regular intervals before and during exercise.ResultsPerformance time was not different between trials (P = 0.21) but the 4.5-5.2 % difference between CHOI and other trials showed moderate practical significance (Cohen’s d 0.57-0.65). Power output was higher in CHOI relative to other trials (P < 0.01). There were no differences between CHOR and placebo groups for any performance variables. Plasma glucose, insulin and lactate concentrations were higher in CHOI relative to other groups (P < 0.05).ConclusionsIn a fasted and glycogen-reduced state ingestion of a CHO solution during high-intensity exercise enhanced performance through stimulation of insulin-mediated glucose uptake. The CHO mouth rinsing had neither ergogenic effects nor changes in endocrine or metabolic responses relative to placebo.

The Influence of Carbohydrate Mouth Rinse on Self-Selected Intermittent Running Performance.

This study investigated the influence of mouth rinsing a carbohydrate solution on self-selected intermittent variable-speed running performance. Eleven male amateur soccer players completed a modified version of the Loughborough Intermittent Shuttle Test (LIST) on 2 occasions separated by 1 wk. The modified LIST allowed the self-selection of running speeds during Block 6 of the protocol (75-90 min). Players rinsed and expectorated 25 ml of noncaloric placebo (PLA) or 10% maltodextrin solution (CHO) for 10 s, routinely during Block 6 of the LIST. Self-selected speeds during the walk and cruise phases of the LIST were similar between trials. Jogging speed was significantly faster during the CHO (11.3 ± 0.7 km · h(-1)) than during the PLA trial (10.5 ± 1.3 km · h(-1)) (p = .010); 15-m sprint speeds were not different between trials (PLA: 2.69 ± 0.18 s: CHO: 2.65 ± 0.13 s) (F(2, 10), p = .157), but significant benefits were observed for sprint distance covered (p = .024). The threshold for the smallest worthwhile change in sprint performance was set at 0.2 s. Inferential statistical analysis showed the chance that CHO mouth rinse was beneficial, negligible, or detrimental to repeated sprint performance was 86%, 10%, and 4%, respectively. In conclusion, mouth rinsing and expectorating a 10% maltodextrin solution was associated with a significant increase in self-selected jogging speed. Repeated 15-m sprint performance was also 86% likely to benefit from routinely mouth rinsing a carbohydrate solution in comparison with a taste-matched placebo.

The effect of a carbohydrate mouth-rinse on neuromuscular fatigue following cycling exercise.

Carbohydrate (CHO) mouth-rinsing, rather than ingestion, is known to improve performance of high-intensity (>75% maximal oxygen uptake) short-duration (≤1 h) cycling exercise. Mechanisms responsible for this improvement, however, are unclear. The present study aimed to investigate the effect of a CHO mouth-rinse on cycling time-trial (TT) performance and mechanisms of fatigue. On 2 separate occasions, 9 male cyclists (mean ± SD; maximal oxygen uptake, 61 ± 5 mL·kg(-1)·min(-1)) completed 45 min at 70% maximum power output (preload) followed by a 15-min TT. At 7.5-min intervals during the preload and TT, participants were given either a tasteless 6.4% maltodextrin mouth-rinse (CHO) or water (placebo (PLA)) in a double-blind, counterbalanced fashion. Isometric knee-extension force and electromyographic responses to percutaneous electrical stimulation and transcranial magnetic stimulation were measured before, after the preload, and after the TT. There were greater decreases in maximal voluntary contraction after the TT in PLA (20% ± 10%) compared with the CHO (12% ± 8%; P = 0.019). Voluntary activation was reduced following exercise in both trials, but did not differ between conditions (PLA -10% ± 8% vs. CHO -5% ± 4%; P = 0.150). The attenuation in the manifestation of global fatigue did not translate into a TT improvement (248 ± 23 vs. 248 ± 39 W for CHO and PLA, respectively). Furthermore, no differences in heart rate or ratings of perceived exertion were found between the 2 conditions. These data suggest that CHO mouth-rinsing attenuates neuromuscular fatigue following endurance cycling. Although these changes did not translate into a performance improvement, further investigation is required into the role of CHO mouth-rinse in alleviating neuromuscular fatigue.

The Effects of Carbohydrate and Caffeine Mouth Rinsing on Arm Crank Time-Trial Performance

This study aimed to determine whether carbohydrate (CHO) and caffeine (CAFF) mouth rinsing would improve 30 minute arm cranking time-trial performance. Twelve male participants (age 21.54 ± 1.28 years, height 179.46 ± 7.38 cm and mass 73.69 ± 5.40 kg) took part in the current investigation. Participants came to the laboratory on 3 occasions during which they performed 30 minute self-paced arm crank time trials. On one occasion water was given as a mouth rinse for 5 s (PLA), on another occasion a 6.4% CHO solution was given for 5 s and finally a 0.032% CAFF solution was given for 5s. Key measurements of distance covered, heart rate (HR), ratings of perceived exertion (RPE), cadence and power output were recorded throughout all trials. Distance covered during the CAFF (15.43 ± 3.27 km) and CHO (15.30 ± 3.31) mouth rinse trials were significantly (p&lt;0.05) greater in comparison to PLA (13.15 ± 3.36 km). Cadence and power output and velocity were also significantly greater during the CAFF and CHO trials compared to PLA and CHO (p&lt;0.05). No significant (P&gt;0.05) differences between trials were observed for HR and RPE. CAFF and CHO mouth rinse serve to improve 30 minute arm cranking performance by mediating increasing cadence and power output without a concurrent increase in RPE and HR.

Carbohydrate-dependent, exercise-induced gastrointestinal distress.

Gastrointestinal (GI) problems are a common concern of athletes during intense exercise. Ultimately, these symptoms can impair performance and possibly prevent athletes from winning or even finishing a race. The main causes of GI problems during exercise are mechanical, ischemic and nutritional factors. Among the nutritional factors, a high intake of carbohydrate and hyperosmolar solutions increases GI problems. A number of nutritional manipulations have been proposed to minimize gastrointestinal symptoms, including the use of multiple transportable carbohydrates. This type of CHO intake increases the oxidation rates and can prevent the accumulation of carbohydrate in the intestine. Glucose (6%) or glucose plus fructose (8%–10%) beverages are recommended in order to increase CHO intake while avoiding the gastric emptying delay. Training the gut with high intake of CHO may increase absorption capacity and probably prevent GI distress. CHO mouth rinse may be a good strategy to enhance performance without using GI tract in exercises lasting less than an hour. Future strategies should be investigated comparing different CHO types, doses, and concentration in exercises with the same characteristics.

Carbohydrate Mouth Rinse Counters Fatigue Related Strength Reduction.

The purpose was to determine the effect of carbohydrate (CHO) mouth rinse on maximal voluntary contraction (MVC) and neuromuscular output in a fatigued state. It was hypothesized that CHO mouth rinse would potentiate torque output in a fatigued state. In a double-blind, cross-over design, 12 competitive male athletes (9 rowers, 1 cyclist, 1 runner and 1 volleyball player) initially performed 3 × 5 s MVC isometric knee extensions followed by a 50% MVC contraction until volitional exhaustion, with quadriceps muscle activity measured via electromyography (EMG). Immediately after, either an 8% CHO maltodextrin (WASH), or noncaloric artificial sweetener (PLA) was mouth rinsed for 10sec, before 3 × 5 s final MVCs. Fatigue caused a significant decline in post fatigue MVC trial 1 for 3 s average torque (p = .03) and peak torque (p = .02) for PLA. This fatigue related decline in torque was not noticed for WASH, with a 2.5% and 3.5% less attenuation in peak and average torque, respectively in post fatigue MVC1 compared with PLA. The effect size for MVC trial 1 between WASH/PLA was seen to be small positive (ES = 0.22; 55% likelihood of positive). Overall for EMG RMS, there were no significant differences between PLA and WASH among all muscles. EMG median frequency showed comparable results between conditions with significant reductions due to fatigue. Taken together, this evidence suggests that the attenuation of torque post fatigue was less for CHO mouth rinse than a placebo. Even though the gains were marginal, these discoveries may play an important role in sport performance, as small performance effects can have significant outcomes in real-world competitions.

Can Carbohydrate Mouth Rinse Improve Performance during Exercise? A Systematic Review

The purpose of this review was to identify studies that have investigated the effect of carbohydrate (CHO) mouth rinse on exercise performance, and to quantify the overall mean difference of this type of manipulation across the studies. The main mechanisms involving the potential benefit of CHO mouth rinse on performance was also explored. A systematic review was conducted in the following electronic databases: PubMed, SciELO, Science Direct, MEDLINE, and the Cochrane Library (Cochrane Central Register of Controlled Trials), without limit of searches. Eleven studies were classified as appropriate and their results were summarized and compared. In nine of them, CHO mouth rinse increased the performance (range from 1.50% to 11.59%) during moderate- to high-intensity exercise (~75% Wmax or 65% VO2max, ~1 h duration). A statistical analysis to quantify the individual and overall mean differences was performed in seven of the 11 eligible studies that reported power output (watts, W) as the main performance outcome. The overall mean difference was calculated using a random-effect model that accounts for true variation in effects occurring in each study, as well as random error within a single study. The overall effect of CHO mouth rinse on performance was significant (mean difference = 5.05 W, 95% CI 0.90 to 9.2 W, z = 2.39, p = 0.02) but there was a large heterogeneity between the studies (I2 = 52%). An activation of the oral receptors and consequently brain areas involved with reward (insula/operculum frontal, orbitofrontal cortex, and striatum) is suggested as a possible physiological mechanism responsible for the improved performance with CHO mouth rinse. However, this positive effect seems to be accentuated when muscle and liver glycogen stores are reduced, possibly due to a greater sensitivity of the oral receptors, and require further investigation. Differences in duration of fasting before the trial, duration of mouth rinse, type of activity, exercise protocols, and sample size may account for the large variability between the studies.

Strategies of Dietary Carbohydrate Manipulation and Their Effects on Performance in Cycling Time Trials

The relationship between carbohydrate (CHO) availability and exercise performance has been thoroughly discussed. CHO improves performance in both prolonged, low-intensity and short, high-intensity exercises. Most studies have focused on the effects of CHO supplementation on the performance of constant-load, time-to-exhaustion exercises. Nevertheless, in the last 20 years, there has been a consistent increase in research on the effects of different forms of CHO supplementation (e.g., diet manipulation, CHO supplementation before or during exercise) on performance during closed-loop exercises, such as cycling time trials (TTs). A TT is a highly reproducible exercise and reflects a more realistic scenario of competition compared with the time-to-exhaustion test. CHO manipulation has been performed in various time periods, such as days before, minutes before, during a TT or in a matched manner (e.g. before and during a TT). The purpose of this review is to address the possible effects of these different forms of CHO manipulation on the performance during a cycling TT. Previous data suggest that when a high-CHO diet (~70% of CHO) is consumed before a TT (24-72 h before), the mean power output increases and reduces the TT time. When participants are supplemented with CHO (from 45 to 400 g) prior to a TT (from 2 min to 6 h before the TT), mean power output and time seem to improve due to an increase in CHO oxidation. Similarly, this performance also seems to increase when participants ingest CHO during a TT because such consumption maintains plasma glucose levels. A CHO mouth rinse also improves performance by activating several brain areas related to reward and motor control through CHO receptors in the oral cavity. However, some studies reported controversial results concerning the benefits of CHO on TT performance. Methodological issues such as time of supplementation, quantity, concentration and type of CHO ingested, as well as the TT duration and intensity, should be considered in future studies because small variations in any of these factors may have beneficial or adverse effects on TT performance.

Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state

It is presently unclear whether the reported ergogenic effect of a carbohydrate (CHO) mouth rinse on cycling time-trial performance is affected by the acute nutritional status of an individual. Hence, the aim of this study was to investigate the effect of a CHO mouth rinse on a 60-min simulated cycling time-trial performance commenced in a fed or fasted state. Twelve competitive male cyclists each completed 4 experimental trials using a double-blinded Latin square design. Two trials were commenced 2 h after a meal that contained 2.5 g·kg(-1) body mass of CHO (FED) and 2 after an overnight fast (FST). Prior to and after every 12.5% of total time during a performance ride, either a 10% maltodextrin (CHO) or a taste-matched placebo (PLB) solution was mouth rinsed for 10 s then immediately expectorated. There were significant main effects for both pre-ride nutritional status (FED vs. FST; p < 0.01) and CHO mouth rinse (CHO vs. PLB; p < 0.01) on power output with an interaction evident between the interventions (p < 0.05). The CHO mouth rinse improved mean power to a greater extent after an overnight fast (282 vs. 273 W, 3.4%; p < 0.01) compared with a fed state (286 vs. 281 W, 1.8%; p < 0.05). We concluded that a CHO mouth rinse improved performance to a greater extent in a fasted compared with a fed state; however, optimal performance was achieved in a fed state with the addition of a CHO mouth rinse.

Opposition of Carbohydrate in a Mouth-Rinse Solution to the Detrimental Effect of Mouth Rinsing During Cycling Time Trials

Studies have reported that rinsing the mouth with a carbohydrate (CHO) solution improves cycling time-trial performance compared with rinsing with a placebo solution. However, no studies have compared the effect of mouth rinsing with a no-mouth-rinse control condition. The aim of this study was to compare the effects of a CHO mouth rinse with those of a placebo rinse and a no-rinse condition. Ten male cyclists completed three 1,000-kJ cycling time trials in a randomized, counterbalanced order. At every 12.5% of the time trial completed, participants were required to rinse their mouths for 5 s with either a 6.4% maltodextrin solution (CHO), water (WA), or no solution (CON). Heart rate and ratings of perceived exertion (RPE) were recorded every 25% of the time trial completed. Time to completion was faster in both CHO (65.7 ± 11.07 min) and CON (67.6 ± 12.68 min) than in WA (69.4 ± 13.81 min; p = .013 and p = .042, respectively). The difference between CHO and CON approached significance (p = .086). There were no differences in heart rate or RPE between any conditions. In summary, repeated mouth rinsing with water results in decreased performance relative to not rinsing at all. Adding CHO to the rinse solution appears to oppose this fall in performance, possibly providing additional benefits to performance compared with not rinsing the mouth at all. This brings into question the magnitude of the effect of CHO mouth rinsing reported in previous studies that did not include a no-rinse condition.