Chitosan Substrates Research Articles

High-effective, convenient and environmental-friendly MOFs-chitosan-glyoxal composite film for ceftizoxime adsorption: Behavior and mechanisms.

In this work, a novel PCN-222-chitosan-glyoxal (PCN@CSG2) composite film was constructed by loading PCN-222 in chitosan substrate, and used for ceftizoxime adsorption. The results demonstrated that the PCN@CSG not only had excellent adsorption properties for ceftizoxime, but also maintained excellent structural properties in harsh environments (strong acids and alkalis), making it have good recycling performance. Specifically, the adsorption kinetics and isotherms investigation demonstrated that the adsorption process followed the pseudo-second-order kinetic model and Freundlich isotherm model respectively, indicating that it was a multilayer process mainly controlled by chemisorption. The PCN@CSG possesses excellent absorptive capacity of 561.7 mg·g-1 and reaches equilibrium rapidly within 60 min, which is attributed to the structural advantages of PCN-222 and chitosan. The amino, carboxyl and hydroxyl functional groups of PCN-222 provide numbers of active sites and cationic chitin greatly promoted the electrostatic adsorption with negative ceftizoxime. In addition, the PCN@CSG has the advantages of renewable and environment-friendly for the biodegradation of chitosan. After five consecutive adsorption-desorption cycles, the removal rate was still higher than 90 %, confirming the excellent reusability of PCN@CSG. This work provided a great prospect for the design and application of shaped-MOFs composite materials for the removal of cephalosporins in environmental water.

Green Synthesis of Cobalt Oxide Decorated Chitosan Substrates for Electrochemical Detection of Nitrite and Hydrogen Evolution Reactions

Green Synthesis of Cobalt Oxide Decorated Chitosan Substrates for Electrochemical Detection of Nitrite and Hydrogen Evolution Reactions

Molecular dynamics model quantum field for prediction of the interaction between chitosan–silver nanoparticles

ABSTRACT In this work, a composite material between chitosan and silver oxide nanoparticles (Ag2NPs) was developed. The universal force field option in the Materials Studio® software was applied to the modelled Ag2NPs within a sphere of variable radius, being 11 å the most stable. In addition, each of these models was taken to their state of minimum energy to verify their stability, and then, a simulation was carried out using a canonical ensemble at 298 K. The X-ray diffraction pattern of these models was simulated and is according to those reported for Ag2O. Molecular and quantum dynamics simulations for the models of the chitosan chains in interaction with Ag2ONPs were made. Each proposed model was based on the Schrödinger equation, considering the quantum fields for the interaction of the nanoparticle in the chitosan substrate. It was observed that the fields were deformed, demonstrating that the presence of the nanoparticle on the surface produces deformation in the polymeric matrix, which suggests a phenomenon of surface adsorption that was confirmed with the RDF where a chemical interaction between the polymer and the silver oxide nanoparticles was shown. This result supports that is possible to obtain the chitosan–Ag2ONPs experimentally.

Sustainable regeneration of transformer oil through composite adsorbent of chitosan and sepiolite: a biorefinery approach

ABSTRACT This study introduces an innovative biorefinery approach for sustainably regenerating transformer oil utilizing a composite adsorbent comprised of Chitosan (CS) and Sepiolite (SL). Surface modification analyses, employing BET, SEM, and FTIR techniques, unveiled enhanced adsorption capabilities attributed to pores and folds on the CS-SL composite surface, coupled with uniform SL distribution within the CS substrate. Through systematic evaluations based on color index and transmittance assessments across multiple samples, optimal regeneration was achieved with a 5% volume fraction of the composite absorbent, closely replicating fresh oil properties. Significant improvements were observed in acidity (−62.50%), moisture content (−44.44%), and viscosity (−27.93%), with slight changes in density and a notable rise in flash point (+31.82°C). Electrical properties showed enhancement, with breakdown voltage (+80.00%) and resistivity (+54.93%) increasing, while dissipation factor (−98.00%) and permittivity (−44.74%) decreased, indicating improved energy efficiency. Gas chromatography-mass spectrometry confirmed the removal of oxidation by-products. This study underscores the potential of CS-SL as a sustainable adsorbent for transformer oil regeneration, thereby making significant strides toward environmental sustainability within the framework of Sustainable Development Goals (SDGs) and the principles of biorefinery practices.

Methods to Screen the Adhesion of Fish Cells on Plant-, Algal- and Fungal-Derived Biomaterials.

Cellular agriculture, an alternative and innovative approach to sustainable food production, has gained momentum in recent years. However, there is limited research into the production of cultivated seafood. Here, we investigated the ability of fish mackerel cells (Scomber scombrus) to adhere to plant, algal and fungal-based biomaterial scaffolds, aiming to optimize the cultivation of fish cells for use in cellular agriculture. A mackerel cell line was utilized, and metabolic assays and confocal imaging were utilized to track cell adhesion, growth, and differentiation on the different biomaterials. The mackerel cells adhered and grew on gelatin (positive control), zein, and soy proteins, as well as on alginate, chitosan, and cellulose polysaccharides. The highest adhesion and growth were on the zein and chitosan substrates, apart from the gelatin control. These findings provide a blueprint to enhance scaffold selection and design, contributing to the broader field of cellular agriculture through the development of scalable and eco-conscious solutions for meeting the growing global demand for seafood.

Construction of chitosan-gelatin polysaccharide-protein composite hydrogel via mechanical stretching and its biocompatibility in vivo

Natural polysaccharides and protein macromolecules are the important components of extracellular matrix (ECM), but individual component generally exhibits weak mechanical property, limited biological function or strong immunogenicity in tissue engineering. Herein, gelatin (Gel) was deposited to the stretched (65 %) chitosan (CS) hydrogel substrates to fabricate the polysaccharide-protein CS-Gel-65 % composite hydrogels to mimic the natural component of ECM and improve the above deficiencies. CS hydrogel substrates under different stretching deformations exhibited tunable morphology, chemical property and wettability, having a vital influence on the secondary structures of deposited fibrous Gel protein, namely appearing with the decreased β-sheet content in stretched CS hydrogel. Gel also produced a more homogenous distribution on the stretched CS hydrogel substrate due to the unfolding of Gel and increased interactions between Gel and CS than on the unstretched substrate. Moreover, the polysaccharide-protein composite hydrogel possessed enhanced mechanical property and oriented structure via stretching-drying method. Besides, in vivo subcutaneous implantation indicated that the CS-Gel-65 % composite hydrogel showed lower immunogenicity, thinner fibrous capsule, better angiogenesis effect and increased M2/M1 of macrophage phenotype. Polysaccharide-protein CS-Gel-65 % composite hydrogel offers a novel material as a tissue engineering scaffold, which could promote angiogenesis and build a good immune microenvironment for the damaged tissue repair.

Nanomagnetic chitosan/β-cyclodextrin for dispersive solid phase extraction of trace desipramine drug

In recent years, there has been an increase in the amount of pharmaceutical medication contamination of water sources. They are extremely difficult to detect since they are only present in trace amounts. In the presented study, the extraction method of dispersive solid phase was paired with HPLC as an easy, effective, and developed approach for preconcentration and measurement of desipramine drug, a depression medication, in aqueous and urine samples with nanomagnetic chitosan/β-cyclodextrin. The sorbent was produced from magnetic nanoparticles of (Fe3O4) in chitosan substrate modified with β-cyclodextrin (βCD) for increasing porosity, and then it was distinguished by several methods, containing X-ray diffraction, infrared spectroscopy, vibrating sample magnetometry, energy dispersive X-ray analysis, and field emission scanning electron microscopy. The significant elements affecting extraction effectiveness are optimized as pH, ionic strength of the solution, amount of adsorbent, the type of elution solvent, temperature and time adsorption, and elution solvent volume (in a multivariate method with the help of the Design Expert program). The results show the very good performance of this technique. The calibration curve of the method is a range of linear of 2–50 μg/L. The detection limit of the method is 0.39 μg/L, the 2.50% relative standard deviation in the method, and the correlation coefficient is 0.98. The maximum adsorbent capacity was recorded at 59.98 mg g−1.

Structure-based mining of a chitosanase with distinctive degradation mode and product specificity.

Chitosan derivates with varying degrees of polymerization (DP) have attracted great concern due to their excellent biological activities. Increasing the abundance of chitosanases with different degradation modes contributes to revealing their catalytic mechanisms and facilitating the production of chitosan derivates. However, the identification of endo-chitosanases capable of producing chitobiose and D-glucosamine (GlcN) from chitosan substrates has remained elusive. Herein, an endo-chitosanase (CsnCA) belonging to the GH46 family was identified based on structural analysis in phylogenetic evolution. Moreover, we demonstrate that CsnCA acts in a random endo-acting manner, producing chitosan derivatives with DP ≤ 2. The in-depth analysis of CsnCA revealed that (GlcN)3 serves as the minimal substrate, undergoing cleavage in the mode that occupies the subsites - 2 to + 1, resulting in the release of GlcN. This study succeeded in discovering a chitosanase with distinctive degradation modes, which could facilitate the mechanistic understanding of chitosanases, further empowering the production of chitosan derivates with specific DP. KEY POINTS: • Structural docking and evolutionary analysis guide to mining the chitosanase. • The endo-chitosanase exhibits a unique GlcN-producing cleavage pattern. • The cleavage direction of chitosanase to produce GlcN was identified.

Production, Characterization and Application of a Novel Chitosanase from Marine Bacterium Bacillus paramycoides BP-N07.

Chitooligosaccharides (COS), a high-value chitosan derivative, have many applications in food, pharmaceuticals, cosmetics and agriculture owing to their unique biological activities. Chitosanase, which catalyzes the hydrolysis of chitosan, can cleave β-1,4 linkages to produce COS. In this study, a chitosanase-producing Bacillus paramycoides BP-N07 was isolated from marine mud samples. The chitosanase enzyme (BpCSN) activity was 2648.66 ± 20.45 U/mL at 52 h and was able to effectively degrade chitosan. The molecular weight of purified BpCSN was approximately 37 kDa. The yield and enzyme activity of BpCSN were 0.41 mg/mL and 8133.17 ± 47.83 U/mg, respectively. The optimum temperature and pH of BpCSN were 50 °C and 6.0, respectively. The results of the high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC) of chitosan treated with BpCSN for 3 h showed that it is an endo-chitosanase, and the main degradation products were chitobiose, chitotriose and chitotetraose. BpCSN was used for the preparation of oligosaccharides: 1.0 mg enzyme converted 10.0 g chitosan with 2% acetic acid into oligosaccharides in 3 h at 50 °C. In summary, this paper reports that BpCSN has wide adaptability to temperature and pH and high activity for hydrolyzing chitosan substrates. Thus, BpCSN is a chitosan decomposer that can be used for producing chitooligosaccharides industrially.

Development of chitosan-based antibacterial and antioxidant bioactive film incorporated with carvacrol-loaded modified halloysite nanotube

The chitosan (CS)-based bioactive packaging film with good antibacterial and antioxidant activities was developed using AHNT (modified halloysite nanotube) loaded with carvacrol (AHNT-Car) as the nanofiller. The zeta potential, Fourier transform infrared, and rheology analysis indicated that hydrogen bonding and electrostatic interactions were formed between AHNT-Car and CS film substrate, and scanning electron microscope images exhibited that the cross-sections of the bioactive film were denser. The mechanical and barrier properties (water vapor, oxygen, and light barrier properties) of the bioactive film were enhanced by adding AHNT-Car due to the hydrogen bonding, electrostatic interactions, and compact structure. Specifically, when the additional amount of AHNT-Car was 10 wt%, the film's tensile, oxygen barrier, and water vapor barrier properties were improved by 49.7%, 36.78%, and 11.92%, respectively. Moreover, compared to CS-Car film (adding Car into the CS film directly), the CS-10% film (AHNT-Car added at 10 wt%) had a slow-release effect on Car and could effectively protect the Car from external high temperature and UV light. In addition, the prepared bioactive film had sustained antioxidant and antibacterial properties and could significantly slow down the spoilage of pork during storage, proving the promising application of the bioactive film as food packaging.

One-step cross-linking of amino-rich chitosan aerogels for efficient and selective adsorption of uranium from radioactive nuclear wastewater

Extraction of uranium from radioactive wastewater is a critical challenge in the modern era of the prevalence of nuclear fuel. Herein, polyethyene polyamine/polydopamine modified carboxylated chitosan aerogels (PEPAx/PDAy-CMCSm-n) were obtained by a simple one-step cross-linking method for efficient and selective uranium adsorption. Carboxylation of chitosan substrates greatly improved solubility in water, which increased flexibility for biomass chitosan modification. More importantly, the PDA bonded coating avoided the problem of low availability of reactive sites caused by steric hindrance between CMCS and PEPA. The abundant –NH2 in the surface modifier PEPA endowed the chitosan aerogels with sufficient active sites, making it exhibit a high uranium adsorption capacity of 467.73 mg g−1. The optimal preparation scheme of aerogels was designed by comprehensive orthogonal experiments for the reactive monomer additive amounts. The obtained PEPA2.0/PDA0.7-CMCS3.5–250 showed prominent kinetics, excellent selectivity and superior regeneration performance. Importantly, reducing uranium concentration from 12.35 mg L-1 to 10 ug L-1 in simulated nuclear wastewater, which is below the Ministry of Environmental Protection of the People’s Republic of China uranium limit for drinking water (30 ug L-1). Besides, the density functional theory calculations revealed the binding mechanism and coordination mode between the adsorption unit and UO22+. Such efficient and low-cost adsorbed aerogels are extremely advantageous for uranium capture in real environments.

Biological characterization of microwave based synthesized ZnO and Ce doped ZnO nanoflowers impeded chitosan matrix with enhanced antioxidant and anti-diabetic properties

The chitosan matrix was used as a substrate for ZnO nanoflowers (ZnO/CH) and Ce-doped ZnO nanoflowers (Ce-ZnO/CH) by microwave-induced hydrothermal synthesis processes. The obtained hybrid structures were assessed as enhanced antioxidant and antidiabetic agents considering the synergetic effect of the different components. The integration of chitosan and cerium induced significantly the biological activity of ZnO flower-like particles. Ce-doped ZnO nano-flowers show higher activities than both ZnO nanoflowers and ZnO/CH composite reflecting the strong effect of surface electrons that were formed by the doping process as compared to the high interactive interface of the chitosan substrate. As an antioxidant the synthetic Ce-ZnO/CH composite achieved remarkable scavenging efficiencies for DPPH (92.4 ± 1.33 %), nitric oxide (95.2 ± 1.81 %), ABTS (90.4 ± 1.64 %), and superoxide (52.8 ± 1.22 %) radicals which are significantly higher values than Ascorbic acid as standard and the commercially used ZnO nanoparticles. Also, its antidiabetic efficiency enhanced greatly achieving strong inhibition effects on porcine α-amylase (93.6 ± 1.66 %), crude α-amylase (88.7 ± 1.82 %), pancreatic α-glucosidase (98.7 ± 1.26 %), crude intestinal α-glucosidase (96.8 ± 1.16 %), and amyloglucosidase (97.2 ± 1.72 %) enzymes. The recognized inhibition percentages are notably higher than the determined percentages using miglitol drug and slightly higher than acarbose. This recommends the Ce-ZnO/CH composite as a potential antidiabetic and antioxidant agent compared with the high cost and the reported side effects of the commonly used chemical drug.

Heterogeneous catalytic oxidation regeneration of desulfurization-rich liquor with Fe3+ modified chitosan

To solve the problem of pipeline blockage caused by sulfur deposition in industrial gas wet oxidative desulfurization operations, this study developed an iron-modified chitosan catalyst for the catalytic oxidation regeneration of conventional wet oxidative desulfurization-rich liquids. Detailed characterization results show that Fe3+ species are successfully coordinated with the chitosan substrate. The results of desulfurization and regeneration experiments showed that the Fe3+-modified chitosan could effectively regenerate the desulfurization waste stream and remain stable in the acidic desulfurization stream. The powdered iron-based modified chitosan catalyst prepared with a mass ratio of chitosan to FeCl3 of 1:5 and glutaraldehyde of 12.5% by mass has better catalytic performance than the microbead counterpart. The regeneration performance of the catalyst was evaluated by the desulfurization performance of the regenerated desulfurization solution. The iron-based modified chitosan shows a good regeneration performance, and the loss of Fe content is less than 1.5% after five runs. This study provides an efficient way to develop cost-effective catalysts for the regeneration of wet oxidative desulfurization-rich liquids.

High-strength and recyclable pure chitosan films manufactured by an ionic liquid assisted roll-forming method

Chitosan materials perform a great potential for applications in sustainable and flexible electronics, owing to their abundance, biocompatibility, and biodegradability. While limited by the inherent shortcoming of having a melting temperature higher than its degradation temperature, chitosan is hard to be manufactured by traditional thermoforming or solvent-free methods. Herein, we demonstrated a tractable roll-forming method to process chitosan films under the plasticizing effect of ionic liquids. In particular, the additional ionic liquids could be removed by Soxhlet extraction and then recycled toward sustainability. The final regenerated chitosan films exhibited outstanding strength (53.1 MPa), high elongation (3.5%) and hardness (0.4 GPa). Simultaneously, the successful fabrication of interdigital electrode sensors on the chitosan film indicated the feasibility of manufacturing flexible electronics using chitosan substrates. Thus, our innovative strategy enables the sustainable formation of high-performance chitosan films, offering a broader prospect for the new generation of chitosan-based biodegradable electronics.

Design and Fabrication of a Plastic-Free Antenna on a Sustainable Chitosan Substrate

The majority of wearable and flexible 5G and 6G devices are based on plastic substrates, that are harmful to the environment. Therefore, the development of sustainable and plastic-free radio frequency (RF) devices becomes a crucial issue. In this regard, we present a fully biocompatible Planar Inverted-F Antenna (PIFA), fabricated on a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$55 ~\mu \text{m}$ </tex-math></inline-formula> -thick chitosan substrate. Chitosan has a relative dielectric constant of 5. This antenna is working at 4.5 GHz in the sub-6 GHz band of the 5G spectrum. It has a very compact footprint of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$14\times23$ </tex-math></inline-formula> mm2 and a Specific Absorption Rate (SAR) of 0.41 W/kg. The prototype has been fabricated using an innovative fabrication protocol. A very good agreement between numerical and experimental results has been obtained. The measured realized gain is equal to 1 dBi at the resonant frequency. Our results demonstrate the suitability of chitosan as a dielectric substrate for the fabrication of plastic-free antennas and paves the way for the development of sustainable wearable devices for the Internet of Healthcare Things (IoHT) applications.

ZnO nanowires based degradable high-performance photodetectors for eco-friendly green electronics

Disposable devices designed for single and/or multiple reliable measurements over a short duration have attracted considerable interest recently. However, these devices often use non-recyclable and non-biodegradable materials and wasteful fabrication methods. Herein, we present ZnO nanowires (NWs) based degradable high-performance UV photodetectors (PDs) on flexible chitosan substrate. Systematic investigations reveal the presented device exhibits excellent photo response, including high responsivity (55 A/W), superior specific detectivity (4x10¹⁴ jones), and the highest gain (8.5x10¹⁰) among the reported state of the art biodegradable PDs. Further, the presented PDs display excellent mechanical flexibility under wide range of bending conditions and thermal stability in the measured temperature range (5–50 °C). The biodegradability studies performed on the device, in both deionized (DI) water (pH≈6) and PBS solution (pH=7.4), show fast degradability in DI water (20 mins) as compared to PBS (48 h). These results show the potential the presented approach holds for green and cost-effective fabrication of wearable, and disposable sensing systems with reduced adverse environmental impact.

Porous 3D Graphene from Sustainable Materials: Laser Graphitization of Chitosan

AbstractLaser‐fabrication of graphene from cellulose‐based feedstock materials often requires extensive preprocessing. This work demonstrates laser fabrication of porous, 3D graphene from a new class of marine‐based sustainable materials–chitosan biopolymers. The biopolymer films contain only chitosan, acetic acid, glycerol, and water. Fourier transform infrared spectroscopy studies indicate that the cured chitosan films still retain a significant water content (≈30%), enabling production of flexible films. A simple 3‐step laser fabrication process is presented using low‐cost infrared (CO2, 2.1 W) and visible (405 nm, 0.5 W) hobbyist laser engravers, with measured sheet resistance values as low as 40 ohms sq.−1. Transient electrochemical detection of an inner sphere redox molecule is demonstrated using a graphene‐like carbon working electrode fabricated on a water‐soluble chitosan substrate.

Ultra‐Flexible Biodegradable Pressure Sensitive Field Effect Transistors for Hands‐Free Control of Robot Movements

Sensitive flexible pressure sensors are needed in applications such as health monitoring, robotics, and wearable systems. Herein, crumpled graphene flakes network (c‐GFN) channel based highly sensitive pressure sensing field effect transistors (PRESSFETs) are presented. The solution‐processed PRESSFET devices are developed on ultrathin (≈3 μm thick) biodegradable graphene oxide–chitosan (GO–CS) substrate. The distinctive crumpled morphology of GFN leads to a bandgap of 800 meV, which allows the device to have clear ON and OFF electronic states and low subthreshold swing. The presented device can work over a dynamic pressure range (0.5–2 kPa), while exhibiting good electrical stability and repeatability during rapid switching. The application of the presented device is demonstrated by attaching them to the temple regions of the face and pressing them with flexure and relaxation of respective temporalis muscles for hands‐free control of the movements of a robotic device. The pressure sensing device turns ON when the facial temporalis muscle is flexed and returns to the OFF state when it is relaxed. Finally, the degradability of the devices is presented to demonstrate their easy disposability and potential for zero electronic waste.

Changes of cell membrane fluidity for mesenchymal stem cell spheroids on biomaterial surfaces.

BACKGROUNDThe therapeutic potential of mesenchymal stem cells (MSCs) in the form of three-dimensional spheroids has been extensively demonstrated. The underlying mechanisms for the altered cellular behavior of spheroids have also been investigated. Cell membrane fluidity is a critically important physical property for the regulation of cell behavior, but it has not been studied for the spheroid-forming cells to date.AIMTo explore the association between cell membrane fluidity and the morphological changes of MSC spheroids on the surface of biomaterials to elucidate the role of membrane fluidity during the spheroid-forming process of MSCs.METHODSWe generated three-dimensional (3D) MSC spheroids on the surface of various culture substrates including chitosan (CS), CS-hyaluronan (CS-HA), and polyvinyl alcohol (PVA) substrates. The cell membrane fluidity and cell morphological change were examined by a time-lapse recording system as well as a high-resolution 3D cellular image explorer. MSCs and normal/cancer cells were pre-stained with fluorescent dyes and co-cultured on the biomaterials to investigate the exchange of cell membrane during the formation of heterogeneous cellular spheroids.RESULTSWe discovered that vesicle-like bubbles randomly appeared on the outer layer of MSC spheroids cultured on different biomaterial surfaces. The average diameter of the vesicle-like bubbles of MSC spheroids on CS-HA at 37 °C was approximately 10 μm, smaller than that on PVA substrates (approximately 27 μm). Based on time-lapse images, these unique bubbles originated from the dynamic movement of the cell membrane during spheroid formation, which indicated an increment of membrane fluidity for MSCs cultured on these substrates. Moreover, the membrane interaction in two different types of cells with similar membrane fluidity may further induce a higher level of membrane translocation during the formation of heterogeneous spheroids. CONCLUSIONChanges in cell membrane fluidity may be a novel path to elucidate the complicated physiological alterations in 3D spheroid-forming cells.

Biodegradation Control of Chitosan Materials by Surface Modification with Copolymers of Glycidyl Methacrylate and Alkyl Methacrylates

Chitosan is a promising polymer from natural polysaccharides, which is an environmentally friendly compound from renewable raw materials. Chitosan has biodegradability, biocompatibility, and antibacterial and other activities. In this article, we report the biodegradation control of chitosan materials by use of random copolymers based on glycidyl methacrylate and (fluoro)alkyl methacrylates as surface modifiers. We show that grafting of copolymers allows increasing the hydrophobicity of chitosan materials with initial contact angles up to 114° from 89° for films and up to 154° from 123° for aerogels. We demonstrate that modified aerogels retain contact angles of more than 150° for a long contact time with water while the initial aerogel fully wets for 30 s. The resulting chitosan aerogels have high porosity with a pore size of 100–200 µm, and the pore walls are 0.6–0.7-µm-thick film formations. Our study of lyophilic properties of modified chitosan substrates showed a change in the hydrophobicity of the materials as a function of length of the hydrocarbon radical in the side groups of the (fluoro)alkyl methacrylates in the copolymers. We demonstrate that the rate of biodegradation of the resulting materials decreases with an increase in the number of hydrophobic groups in the modifier. The obtained chitosan materials with hydrophobic coatings have potential as a protective layer for wound dressings with an extended service life.