AimPresent work mainly deals with the formulation of colon targeting dosage form of budesonide, using natural polysaccharides as polymer by utilizing spray drying technique. Budesonide is locally acting corticosteroid utilized for the treatment of inflammatory bowel disease. Budesonide is having high glucocorticoid and low mineralocorticoid effect. MethodsChemical modification of chitosan was carried out by using glutaraldehyde which causes crosslinking between chitosan molecules rendering them water insoluble. Drug, polymer and crosslinking agent were spray dried to form microparticles. 2 ml of 25% glutaraldehyde was found to be necessary for required crosslinking of 1% chitosan in acetic acid. ResultsFormed microparticles showed 20% drug release in initial 5 h and 80% drug release in rat fecal content media which also suggested that specific degradability of chitosan by colonic bacteria remains after crosslinking also. Formed microparticles were then evaluated for various parameters like morphology, particle size distribution, % yield, % entrapment, % of loading and drug release. ConclusionSpray drying produces narrow and small size microparticles of budesonide.