Chiralcel OD-H Columns Research Articles

Chiral HPLC Separations for Process Development of S-(+)-Isobutyl Gaba, a Potential Anti-epileptic Agent

Abstract In order to develop an economically-viable route to make S-(+)-isobutyl GABA ((S)3-aminomethyl-5-methylhexanoic acid), many intermediates required chiral analyses to determine their enantiomeric purities. Multiple chiral stationary phases were employed for this purpose. Chiralcel OD-H and Chiralpak AD columns resolved more than 80 % of the tested intermediates.