Chiral Ferrocene Derivatives Research Articles

Enzymatic resolution of planar chiral ferrocene derivatives

AbstractRacemic 3‐methyl, 2‐ethyl, 2‐bromo, and 2‐trimethylsilyl derivatives of formylferrocene were kinetically resolved by enantioselective reduction with a fermenting baker's yeast. Moreover, 2‐methyl, 3‐methyl, 2‐ethyl, 2‐bromo, and 2‐trimethylsilyl derivatives of hydroxymethylferrocene were optically resolved with lipases by transesterification using vinyl esters.