Organic electrochemical transistors (OECTs) hold great potential in various applications, including biosensing and neural network computation. Traditional “all-in-one” OECT device architecture faces the problems of unclear amplification mechanisms and complex side reactions, to name a few. The reaction cell OECT (RC-OECT) device architecture, proposed by Ting et al. [Adv. Funct. Mater. 31(19), 2010868 (2021)], effectively resolves these problems. Furthermore, in many applications of OECTs, such as high throughput (bio)sensing, an OECT device array instead of a single OECT is needed. Therefore, the size (area) of the OECT device, which represents the amount of occupied chip real estate and the integration of the device, matters. In this paper, we developed a hydrogen peroxide sensor based on the RC-OECT. We utilized an RC cathode modified by the poly(3,4-ethylenedioxythiophene) polystyrene sulfonate film and a Ag/AgCl OECT gate electrode for facilitating device integration, varied RC anode area, and achieved optimization of at least one of the two parameters, sensitivity and lower limit of detection (LLoD), in conjunction with the level of integration of the device. Multiple quantitative sensitivity metrics have been adopted in this work. We also evaluated the correlation between RC anode area and LLoD. In addition, a mechanistic analysis of the RC-OECT device structure, in terms of faradic and non-faradaic currents, was carried out to illustrate the interplay between sensing performance and the electrode area of the reaction cell. This mechanistic analysis provides insights for miniaturizing OECT devices with the RC-OECT architecture.
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