Objective To observe the effect of gliosidle ( GM1 ) combines with ozagrel therapy the Acute Cerebral Infarction .Methods 80 patients from the onset within 72 h were randomly divided into two groups.The treatment group were treated with GM1 combines with ozagrel ,the control group were treateal with ozagrel.To observe the curative effect of after a peride of treatment (fourteen days ).The Chinese Stroke Scale (CSS),Barthel lndex(Bl) were used to evaluatd the recovery of neurological funitions.Resuits The obvious effective rate of the therapy was 57.5% response rate was 25%, whereas, these date of the control group were 30% and 45% ; respectively.The Barthel Index significantly changed in treatment group( P<0.05 ).Conclusion It's effect on therapy the acute cerebral infarction was better in the therapy group than in the control group. Key words: Monosialotetrahexosylganglioside; Ozagred; Cerebral infarction; Carative effect