SARS-CoV-2 is the name of a new strain of coronavirus that was first reported in Wuhan City, the Chinese province of Hubei, in the middle of December 2019. The new viral disease has spread at an alarming rate worldwide, despite extreme anti-epidemic measures and strategies taken by many countries to limit the pandemic. Various activities of active and passive screening in the General practice have implemented to constrain the transamination of coronavirus infection. They involve a series of actions for informing and education of patients, early identification of suspected cases and management of patient with viral infection. To date, there is no approved vaccine or specific antiviral treatment available for COVID- 19. Further research is needed to understand in detail the life cycle of SARS-CoV-2, to detect the original source of the virus, to establish the mechanisms of transmission, as well as to develop effective methods for prevention of the onset of an infectious process and adequate treatment. It is necessary to be presented reliable scientific evidence that will contribute to more effective and quality screening in the General Practice. In this moment, all protective measures in the General medicine's office need to be focused on providing better protection for healthcare professionals and patients.