Chinese Medical Treatment Research Articles

Exploring the mechanisms and current status of acupuncture in alleviating tumor metabolism and associated diseases: Insights from the central nervous system and immune microenvironment

Acupuncture, as a traditional Chinese medical treatment, has garnered increasing attention in recent years in fields such as tumor metabolism, the central nervous system, and the immune microenvironment. This paper aims to explore the fundamental principles, mechanisms, and research status of acupuncture therapy for tumor-related diseases. Firstly, we introduce the basic principles of acupuncture therapy, including the theories of meridians and its theoretical basis in tumor treatment. Secondly, we systematically review the mechanisms of acupuncture therapy for tumor-related diseases, discussing how acupuncture alleviates side effects such as pain, depression, fatigue, and gastrointestinal discomfort caused by conventional treatments through modulation of the immune microenvironment, central nervous system, and endocrine system. Subsequently, we discuss the current research status of acupuncture therapy for tumor-related diseases, as well as the application of current research methods and technologies in elucidating acupuncture mechanisms. Additionally, by combining clinical practice with different types of tumor-related diseases as experimental subjects, we demonstrate the application effectiveness and clinical practice experience of acupuncture in tumor treatment. Finally, a comprehensive assessment of acupuncture therapy for tumor-related diseases is provided, summarizing its limitations and prospecting future directions, including interdisciplinary collaboration and personalized treatment. In conclusion, acupuncture, as a feasible adjunctive therapy, is closely related to the central nervous system and the immune microenvironment, holding potential significant value in tumor treatment.

Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2024 edition)

To further standardize lung cancer prevention and treatment measures in China, enhance the quality of diagnosis and treatment, improve patient prognosis, and provide evidence-based medical guidance for clinicians at all levels, the Chinese Medical Association convened experts from respiratory medicine, oncology, thoracic surgery, radiotherapy, imaging, and pathology to develop the Chinese Medical Association's Clinical Diagnosis and Treatment Guidelines for Lung Cancer (2024 edition). This consensus resulted in several updates from the 2023 version. The 2024 guidelines highlight that the risk of lung cancer in smokers remains higher than that of non-smokers even 15 years after quitting. Additionally, a new lung cancer incidence risk model is expected to become a critical tool for screening high-risk groups. In pathology, the guidelines now include pathological evaluation of surgically resected lung cancer specimens following neoadjuvant therapy and suggest that immunohistochemical staining of certain transcription factors may aid in the classification of small cell lung cancer (SCLC). In molecular detection, the guidelines propose simultaneous detection of driver gene variations based on both RNA and DNA from specimens. The new edition also provides detailed descriptions of patient selection and surgical requirements for thoracic sub-lobectomy, aligned with the 9th TNM staging. Moreover, the guidelines expand treatment options, approving more therapies for immunoadjuvant and EGFR-TKI resistant lung cancer patients, as well as additional drug options for advanced non-small cell lung cancer (NSCLC) patients with EGFR mutations, EGFR 20 insertions, ALK fusions, and MET exon 14 skipping. These recommendations are based on state-approved drug applications, international guidelines, and current clinical practices in China, integrating the latest evidence-based medical research in screening, diagnosis, pathology, genetic testing, immune molecular marker detection, treatment methods, and follow-up care. The goal is to provide comprehensive and reasonable recommendations for clinicians, imaging specialists, laboratory technicians, rehabilitation professionals, and other medical staff at all levels.

Analysis of the coupling coordination between traditional Chinese medicine medical services and economy and its influencing factors in China.

The coordinative relationship between medical treatment and the economy is an important part of promoting the sustainable and healthy development of a social economy, and it is conducive to promoting the coordinated development of the two systems. Based on constructing a comprehensive evaluation index system for the relationship between traditional Chinese medicine medical services and economic development, the entropy method, coupling coordination model, and Tobit model are used to calculate the comprehensive development level, coupling coordination degree, and influencing factors of the two systems in 31 provinces of China from 2015 to 2021. Suggestions are proposed for the coordinated development of traditional Chinese medicine medical services, and economy. The results showed that the development level of traditional Chinese medicine was higher than that of social and economic development, the relative development gap between the two systems was gradually narrowed, and the coupling coordination degree increased steadily; however, the regional differences were large. The relative development level and coupling coordination degree of each region show a development pattern of eastern > central > western > northeast; the coupling coordination degree of the two systems in the spatial region was positively correlated and was enhanced year by year. From the perspective of influencing factors, the level of economic development is the decisive factor in the coupling and coordination between traditional Chinese medicine medical treatment and the social economy. Factors such as human capital and health level in traditional Chinese medicine have an inhibitory effect on the coordinated development of the two systems. So, China should focus on optimizing the regional allocation of traditional Chinese medicine medical personnel, improving the quality of medical services, and enhancing the health level of medical personnel.

Progress of Research on Chinese and Western Medical Treatment of Uterine Prolapse

Progress of Research on Chinese and Western Medical Treatment of Uterine Prolapse

Analysis of treatment methods for canine and feline dermatomycosis

Dermatomycosis is a kind of superficial infectious disease of skin, mucous membrane and skin accessory organ, which is caused by fungi. Dermatomycosis is a zoonosis characterized by recurrent, infectious and high morbidity. Nowadays, all studies on the treatment of dermatomycosis in cats and dogs are relatively scattered, so the purpose of this research is to analyze the therapeutic drugs of the dermatomycosis comprehensively by comparing the experimental data and results in other literatures, and point out the cons and pros and the target groups. Terbinafine is a good choice for both topical and systemic use or even as a medicated bath. For topical antibacterial treatment, ketoconazole, which has uncertain hepatotoxicity, is not recommended for young pets or those whose liver function is impaired. For systemic treatment, the itraconazole suspension is a better option, and fluconazole is not recommended to be the first choice if the sick animal is canine due to dogs’ poor sensitivity to it. Among the Chinese medicines, simple Chinese gallnut solution, compound prescription composed of Chinese gallnut, smoked plum and other 8 Chinese herbs, and a shampoo called Sanzi Qingbai are both safe and effective treatments, which is less likely to develop drug resistance. People should consider the overall condition of the sick animal and the nature of the drugs when choosing the most suitable treatment, and the combination of Chinese and Western medical treatments is also a new direction.

Progress in the Pathogenesis of Idiopathic Pulmonary Fibrosis and the Application of Chinese and Western Medical Treatments

Progress in the Pathogenesis of Idiopathic Pulmonary Fibrosis and the Application of Chinese and Western Medical Treatments

Intrapulmonary migration of a fractured acupuncture needle: a case report

BackgroundAcupuncture, a traditional Chinese medical treatment, has been gaining popularity over the years. However, it also presents certain risks. We report a case of a patient who discovered a foreign body in their lung several years after undergoing acupuncture.Case presentationA middle-aged woman presented to our hospital with chest pain. An X-ray revealed a needle-like foreign body in the middle lobe of her right lung. The patient had previously undergone acupuncture treatment for local pain in her lower back and lower extremities many years prior. Based on the imaging findings and her medical history, we hypothesized that the foreign body in her lung was a result of a dislodged acupuncture needle. Through preoperative 3-dimensional reconstruction and indocyanine green localization, we were able to locate the foreign body in the lateral segment of the right middle lobe. We successfully removed the foreign body via wedge resection, and the patient made a smooth recovery post-surgery.ConclusionAcupuncturists and surgeons should remain vigilant about the potential risks associated with acupuncture.

Confirmation of pain-related neuromodulation mechanism of Bushen Zhuangjin Decoction on knee osteoarthritis

Ethnopharmacological relevanceBushen Zhuangjin Decoction (BZD) are an herbal compound commonly used to treat osteoarthritis (OA) in China. Aim of the studyThis study aimed to verify the mechanism of Bushen Zhuangjin Decoction in relieving the pain of knee osteoarthritis. Materials and methodsNetwork pharmacology evaluation was used to discover the potential targets of BZD to relieve pain in KOA. The therapeutic effects of BZD treatment on KOA pain using histomorphology, behavioral assessments, suspension chip analysis, and ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) assays. The functional magnetic resonance imaging was used to explore the effects of BZD treatment on brain function associated to KOA. ResultsNetwork pharmacological analysis revealed the association between the analgesic effect of BZD on KOA and the pain signaling neurotransmitter 5-HT. Subsequently, we conducted experiments to verify the therapeutic effect of BZD on pain in KOA animal models. Behavioral tests demonstrated that the pain threshold of knee osteoarthritis rats decreased in PWT and PWL, but BZD was able to increase the pain threshold. Histopathological staining indicated thinning of the cartilage layer and sparse trabeculae in the subchondral bone. Suspension chip analysis revealed a significant increase in pro-inflammatory factors of IL-1α, IL-5, IL-12, IL-17A, RANTES, TNF-α and M-CSF in KOA, along with a significant decrease in anti-inflammatory factor of IL-13. However, BZD treatment decreased the expression of pro-inflammatory factors and increased the content of anti-inflammatory factor. UHPLC-MS/MS analysis showed a significant decrease in the serum levels of GABA, E, GSH, Kyn, Met, and VMA in KOA, which were significantly increased by BZD. Conversely, the serum levels of TrpA, TyrA, Spd, and BALa were significantly increased in KOA and significantly decreased by BZD. ELISA and Western blot analysis showed increased expression of subchondral bone pain-related neuropeptides SP, CGRP, TH, NPY, VEGFA, 5-HT3 in KOA, which were decreased in BZD. Functional magnetic resonance imaging demonstrated that BZD exerts its therapeutic effect on KOA by modulating the activity and functional connections of the cortex, hypothalamus, and hippocampus. ConclusionsThis study confirmed the significant role of pain-related neuromodulation mechanisms in the analgesic therapy of BZD and provides a theoretical foundation for using BZD as a traditional Chinese medical treatment for KOA pain.

A Single Case Study of Cupping Therapy in AVABAHUK (Frozen Shoulder).

Pain has been described by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage”. Shoulder pain is one of the most common health problems encountered in the general population.Shoulder pain is a common symptom, in especially in office workers. In developed countries, approximately twothirds of people experience shoulder pain. This disorder occurs most frequently in the middle-aged population and more often in females than in males. A majority of the acute shoulder sufferers obtain spontaneous relief within days or weeks, although approximately 10% of acute shoulder pain suffers experience the condition as chronic or persistent. Conventional treatments such as medications and surgery were not always effective, and may have serious adverse effects.
 Frozen shoulder is a chronic aseptic inflammation caused by injury and degeneration of shoulder capsule and periarthritic soft tissue (including ligaments, muscles, tendons, synovial sacs, etc.). [i]Cupping is gaining popularity in physical medicine due to its ease of use, lack of side effects, and pain relief. This study looked at the efficacy of cupping therapy for treating shoulder pain. Cupping therapy (CT) is a traditional Chinese medical (TCM) treatment which has been practiced for thousands of years. The World Health Organization’s (WHO) definition of cupping is a therapeutic method involving the application of suction by creating a vacum. This is typically done using fire in a cup or jar on the dermis of the affected part of the body.[ii]
 In this case study a patient diagnosed with AVABAHUK (Frozen Shoulder) was treated with a WET CUPPING THERAPY. After completion of cupping therapy significant relief was observed in symptoms.
 
 
 

Integrated Chinese and Western medicine for stable angina pectoris of coronary heart disease: a real-world study including 690 patients.

We aimed to evaluate the effects of integrated Chinese and Western medical therapeutic modalities on clinical prognosis in a population with stable angina pectoris (SAP) of coronary heart disease (CHD). In a prospective cohort study, 732 patients with SAP of CHD hospitalized in the Integrated Cardiology Unit of the China-Japan Friendship Hospital From October 2020 to October 2021 were included. The patients were divided into integrated treatment and conventional treatment groups according to whether they had been taking Chinese medicine for more than 6 months per year. The occurrence of composite cardiovascular events (CVEs), including cardiac death, non-fatal myocardial infarction, revascularization, stroke, all-cause death, and readmission due to angina attack, heart failure, or malignant arrhythmia, was recorded during follow-up. The effects of different treatment modalities on prognosis were evaluated using univariate and multifactorial logistic regression. Logistic regression models were evaluated using receiver operating characteristic (ROC) curves. In sensitivity analysis, the correlation between treatment modality and outcome events was corrected by rematching the two groups of patients using the propensity score matching (PSM) method. The data from 690 patients were included in the analysis, with 327 patients in the integrated treatment group and 363 patients in the conventional treatment group. CVEs occurred in 19 patients (5.8%) in the integrated treatment group and 37 patients (10.2%) in the conventional treatment group. The proportion of outcome events was significantly lower in the combination treatment group than in the conventional treatment group (P = 0.037). Covariate correction by multimodal multifactorial logistic regression revealed a lower risk of CVEs in patients receiving integrated therapy compared with conventional therapy (OR = 0.246, 95% CI = 0.097-0.622, P = 0.003). Moreover, a history of renal insufficiency (OR = 3.991, 95% CI = 1.164-13.684, P = 0.028) and a higher Gensini score (OR = 1.039, 95% CI = 1.028-1.050, P < 0.001) were risk factors for the development of CVEs. Model evaluation showed that C-statistic = 0.955 and area under the ROC curve (AUC) = 0.955. After PSM correction, the results still showed that integrated Chinese and Western medical treatment reduced the occurrence of CVEs in patients compared with Western treatment alone (OR = 0.339, 95% CI = 0.131-0.874, P = 0.025). Integrated treatment based on Chinese and Western medicine might improve the prognosis and reduce the risk of CVEs in this disease population. China Clinical Trials Registry, ChiCTR1800017891, Registered 20 August 2018, http://www.chictr.org.cn/showproj.aspx?proj = 30170.

Meta-analysis of the efficacy of combined Chinese and Western medical treatment versus western medical treatment alone on pit viper bites

ABSTRACT This paper uses Meta-analysis to explore the differences in the clinical efficacy of combined Chinese and Western medical treatment of pit viper bites versus Western medicine alone. By searching English databases (PubMed, Embase and Cochrane Library) and Chinese databases (CNKI, Wanfang and VIP), we collected original studies related to this problem. After data extraction, meta-analysis was performed using 5.2–0 in R language. In this study, a total of 7891 patients with pit viper bites were included in 9 studies. Combined Chinese and Western medicine treatment may be superior to Western medicine treatment alone with an OR of 5.30 and 95% CI of 3.90–7.21. The combined treatment of Chinese and Western medicine has better clinical results in the recovery of local symptoms in patients with pit viper bites and is more effective than conventional Western medicine alone.

Research progress in Chinese and Western medicine for vestibular migraine

Vestibular migraine (VM) is a genetically predisposed disorder in which recurrent dizziness or vertigo, with or without headache, is the main clinical manifestation. It is one of the main causes of recurrent vertigo, with a predominance of middle-aged women. Its pathogenesis is not fully understood, and there are no authoritative treatment guidelines, and it is mostly managed in the same way as migraine. In order to further clarify the progress of Chinese and Western medical treatment of vestibular migraine, we have integrated the current relevant literature and presented it in the context of Chinese and Western medical understanding and treatment in order to provide reference for subsequent clinical treatment and research.

Progress in the Study of Postoperative Constipation of Mixed Hemorrhoids in Chinese and Western Medical Treatment

Progress in the Study of Postoperative Constipation of Mixed Hemorrhoids in Chinese and Western Medical Treatment

Progress of research on the treatment of constipation from dietary intervention

Nowadays, with the change in living conditions and the adjustment of dietary structure, together with the influence of psycho-spiritual and social factors, the incidence of constipation has (year by year) increased ^[1], which has seriously affected people's quality of life. There are various Chinese and Western medical diagnostic and treatment methods for constipation of different etiologies, and research on the prevention and treatment of constipation by dietary interventions has become a hot topic not infrequently. Therefore, this paper integrates and summarizes the relevant literature in recent years through the theoretical studies on the role of dietary intervention in constipation and its specific clinical applications, and briefly describes some theoretical and practical experiences and guidance on dietary intervention in constipation, providing new ideas and reference bases for the modern application of dietary intervention in the diagnosis and treatment of constipation.

Effectiveness and safety of auricular acupuncture for psoriasis: A protocol for systematic review and meta-analysis.

Psoriasis is a chronic, immune-mediated, polygenic skin disease that is common in clinical practice and often develops on the extremities, back, and scalp of patients. In that psoriasis lesions are stubborn and prone to recurrence, it has a serious impact on patients' quality of life and is detrimental to their physical and psychological health. Auricular acupuncture is one of the traditional Chinese medical treatments, which has the advantages of low adverse effects and simple operation and has been widely used in clinical practice with good efficacy. However, there has been no systematic evaluation of auricular acupuncture in the treatment of psoriasis. This protocol aims to evaluate the effectiveness and safety of auricular acupuncture in patients with psoriasis. We will search the following 8 databases including PubMed, MEDLINE, EMBASE, Cochrane Library, CNKI, Wan Fang, VIP, and CBM databases for randomized controlled trials of auricular acupuncture treated psoriasis from their inception to 10 October 2022. We will analyze the data meeting the inclusion criteria with the RevMan V.5.4 software. Two authors will assess the quality of the study with the Cochrane systematic evaluation tool. Treatment effectiveness and the psoriasis area and severity index are defined as the main outcomes, and the additional outcomes include itchy, dermatology life quality index, relapse rate, and adverse events. This study will review and evaluate the available evidence on the effectiveness and safety of auricular acupuncture for psoriasis. The results of this study will provide evidence for the effectiveness and safety of treating psoriasis, providing clinicians and patients with appropriate treatment options for this disease.

Electroacupuncture promotes remyelination and alleviates cognitive deficit via promoting OPC differentiation in a rat model of subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) is a devastating cerebral vascular disease which causes neurological deficits including long-term cognitive deficit. Demyelination of white matter is correlated with cognitive deficit in SAH. Electroacupuncture (EA) is a traditional Chinese medical treatment which protects against cognitive deficit in varies of neurological diseases. However, whether EA exerts protective effect on cognitive function in SAH has not been investigated. The underlying mechanism of remyelination regulated by EA remains unclear. This study aimed to investigate the protective effects of EA on cognitive deficit in a rat model of SAH. SAH was induced in SD rats (n = 72) by endovascular perforation. Rats in EA group received EA treatment (10min per day) under isoflurane anesthesia after SAH. Rats in SAH and sham groups received the same isoflurane anesthesia with no treatment. The mortality rate, neurological score, cognitive function, cerebral blood flow (CBF), and remyelination in sham, SAH and EA groups were assessed at 21 d after SAH.EA treatment alleviated cognitive deficits and myelin injury of rats compared with that in SAH group. Moreover, EA treatment enhanced remyelination in white matter and promoted the differentiation of OPCs after SAH. EA treatment inhibited the expression of Id2 and promoted the expression of SOX10 in oligodendrocyte cells. Additionally, the cerebral blood flow (CBF) of rats was increased by EA compared with that in SAH group. EA treatment exerts protective effect against cognitive deficit in the late phase of SAH. The underlying mechanisms involve promoting oligodendrocyte progenitor cell (OPC) differentiation and remyelination in white matter via regulating the expression of Id2 and SOX10. The improvement of CBF may also account for the protective effect of EA on cognitive function. EA treatment is a potential therapy for the treatment of cognitive deficit after SAH.

A study of emotion management and identity construction in Chinese medical treatment discussions

Based on a medical corpus, this study attempts to capture how doctors manage their emotions and construct their professional identity in treatment discussions. Using the Emotion Model and the Model of Epistemics and Deontics Gradient, I find that (1) when their professional expertise is questioned or doubted, doctors highlight their epistemic rights and displays negative emotions; (2) when their professional role is negated, doctors give the deontic rights to their patients and discharge negative emotions; and (3) when their professional ethics is challenged, doctors project their professional morality, reinforce their deontic rights and give vent to negative emotions. This study, by integrating the Confucian System of Moral Virtues (see) with Emotion Model, establishes a theoretical framework for examining the association between emotion management and identity construction in Chinese medical discourse.

Question Answering System Based on Knowledge Graph in Traditional Chinese Medicine Diagnosis and Treatment of Viral Hepatitis B.

This article uses the real medical records and web pages of Chinese medicine diagnosis and treatment of hepatitis B to extract structured medical knowledge, and obtains a total of 8,563 entities, 96,896 relationships, 32 entity types, and 40 relationship types. The structured data was stored in the Neo4j graph structure database, and a knowledge graph of Chinese medical diagnosis and treatment of hepatitis B was constructed. The knowledge map is used as a structured data source to provide high-quality knowledge information for the medical question and answer system based on hepatitis B disease. Applying the deep learning method to the question identification and knowledge response of the question answering system makes the hepatitis B medical intelligent question answering system has important research and application significance. The question-and-answer system takes aim at hepatitis B, a public health problem in the world and leverages the advantages of traditional Chinese medicine for diagnosis and treatment. It provides a reference for doctors' disease diagnosis, treatment, and patient self-care. Its value is important for the treatment of hepatitis B disease.

Traditional Chinese Medicine Treatment and Sports Rehabilitation of Sports Dance Athlete's Waist Injury.

The issue of sports injury and rehabilitation has been a hot topic in competitive sports. With the continuous development of sports dance sports requirements and competition system, the competition is becoming increasingly fierce and the special technical requirements are more stringent; it can easily cause eye damage. Traditional Chinese medicine clinics often use Chinese medicine internal treatment, external Chinese medicine, acupuncture, massage, cupping, scraping, exercise, and other treatment methods to treat waist injuries, which have the characteristics of significant curative effect, small side effects, and being not easy to relapse. It plays an important role in the recovery and treatment of athletes, allowing athletes to better repair, reduce physical discomfort, and achieve better results. The increase in training difficulty and intensity leads to more frequent sports injuries, so the recovery of athletes after injury is particularly important. Based on the above background, the purpose of this article was to study the traditional Chinese and Western medical treatment and sports rehabilitation for waist injuries of sports dance athletes. This article analyzes the technical problems existing in the training process of sports dance athletes from the perspective of sports training, and analyzes the nature of sports dance athletes' waist injuries and the causes of injuries. In this article, 45 sports dance athletes were randomly divided into three groups: traditional Chinese medicine and Western medicine, traditional Chinese medicine, and Western medicine. Patients treated with the optimized combination of traditional Chinese and Western medicine were regarded as the traditional Chinese and Western medicine group. The clinical symptoms, limb circumference, waist function rehabilitation, and overall efficacy of the three groups were observed. At the same time, changes in physical examination indicators before and after treatment were observed to evaluate the safety of the treatment. The experimental results showed that the total effective rate of the Chinese and Western medicine group was 95%, the total effective rate of the Chinese medicine group was 84%, and the total effective rate of the Western medicine group was 90%. The symptoms and waist injuries of the three groups were improved to varying degrees. The results of this experiment provide a reference for protecting the physical health and scientific training of athletes, and also provide training ideas and methods for coaches and scientific and medical personnel.

Progress in Traditional Chinese Medicine Syndrome Differentiation and Treatment of Premature Ovarian Failure

Premature ovarian failure has directly or indirectly caused unspeakable physical and mental suffering to many women because of its increasing incidence. People of all ethnic groups in the world are actively seeking the best method, but the results are only basically satisfactory. As far as treatment is concerned, Chinese and Western medical treatments have their own advantages and disadvantages. However, because of the variety of syndrome types in traditional Chinese medicine, there are many descriptions of a single disease syndrome, and there are few systematic generalizations and classifications. Therefore, the experience of traditional chinese medicine in the treatment of premature ovarian failure in recent 10 years is classified and summarized. Traditional chinese medicine believes that the root cause of premature ovarian failure is the disorder of viscera, and the pathological sign is phlegm dampness and blood stasis. Therefore, the treatment should be based on kidney, syndrome differentiation and treatment of multiple viscera, taking into account phlegm dampness and blood stasis, combined with periodic therapy and acupuncture treatment, striving to nourish the kidney, regulate the heart, liver, spleen and lungs, and smooth phlegm dampness and blood stasis, so as to achieve the effect of prevention and treatment.