The unprecedented pace and scope of globalization over the past half century have had major impacts on the field of psychology. We observe that since the 2008 financial crisis, there have been increased academic and political concerns with “deglobalization,” which is often associated with terrorism, xenophobia, authoritarianism, Brexit, the US–China trade war, the Russian war on Ukraine, and the COVID-19 pandemic. We argue that the phenomenon of deglobalization is historically uncertain but intellectually and politically significant enough to warrant analysis. Thus, in this special issue, we begin to theorize the psychology of deglobalization by addressing several foundational issues: the major manifestations of deglobalization in relation to psychosocial life, the dialectical relations between globalization and deglobalization, and possible ways to respond to the challenges of deglobalization. In the meantime, we flesh out these theoretical perspectives using the cases of nationalism, neoliberalism, White supremacy, far-right politics, dehumanization, isolationism, and trade conflicts.